What is timothy grass allergy

What is timothy grass allergy

  1. Vrtala,S.; Fischer,S.; Grote,M.; Vangelista,L.; Pastore,A.; Sperr,W.R.; Valent,P.; Reichelt,R.; Kraft,D.; Valenta,R.; Molecular, immunological, and structural characterization of Phl p 6, a major allergen and P-particle-associated protein from Timothy grass (Phleum pratense) pollenJ. Immunol. 163 (10), 5489-5496 (1999)
  2. Petersen A; Bufe A; Schramm G; Schlaak M; Becker WMCharacterization of the allergen group VI in timothy grass pollen (Phl p 6).

    II.

    What is timothy grass allergy

    cDNA cloning of Phl p 6 and structural comparison to grass group V.Int Arch Allergy Immunol. 1995 Sep;108(1):55-9


Group Sequences

Species Common Allergen Type Length GI# Version
Phleum pratense Common timothy Phl p 6.0102 Aero Plant 138 3004465 7
Phleum pratense Common timothy Phl p 6.0101 Aero Plant 138 3004467 7
Phleum pratense Common timothy Unassigned Aero Plant 106 3004469 7
Phleum pratense Common timothy Unassigned Aero Plant 111 28374072 7

AF099: Berberine bridge enzyme

Biochemical properties

Berberine bridge and berberine bridge-like enzymes are plant enzymes involved in the biosynthesis of numerous isoquinoline alkaloids.

Berberine bridge enzymes catalyze the transformation of the N-methyl group of (S)-reticuline into the C-8 berberine bridge carbon of (S)-scoulerine [1]. Members of this family are flavoproteins that contain a conserved FAD-binding domain.

What is timothy grass allergy

References

  • Facchini PJ, Penzes C, Johnson AG, Bull D:
    Molecular characterization of berberine bridge enzyme genes from opium poppy.
    Plant Physiol 1996, 112, 1669-77. [PubMed]
  • Dewitt AM, Andersson K, Peltre G, Lidholm J:
    Cloning, expression and immunological characterization of full-length timothy grass pollen allergen Phl p 4, a berberine bridge enzyme-like protein with homology to celery allergen Api g 5.
    Clin Exp Allergy 2006, 36, 77-86.

    What is timothy grass allergy

    [PubMed][Full Text]

  • Bublin M, Radauer C, Wilson IB, Kraft D, Scheiner O, Breiteneder H, Hoffmann-Sommergruber K:
    Cross-reactive N-glycans of Api g 5, a high molecular weight glycoprotein allergen from celery, are required for immunoglobulin E binding and activation of effector cells from allergic patients.
    FASEB J 2003, 17, 1697-9. [PubMed][Full Text]
  • Su SN, Shu P, Lau GX, Yang SY, Huang SW, Lee YC:
    Immunologic and physicochemical studies of Bermuda grass pollen antigen BG60.
    J Allergy Clin Immunol 1996, 98, 486-94. [PubMed]
  • Chardin H, Mayer C, Senechal H, Tepfer M, Desvaux FX, Peltre G:
    Characterization of high-molecular-mass allergens in oilseed rape pollen.
    Int Arch Allergy Immunol 2001, 125, 128-34.

    [PubMed][Full Text]

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Allergens from this family

The first identified allergen from this family was BG60 from Bermuda grass pollen [2]. Homology to BBEs was also found for Phl p 4 from timothy grass [3], Api g 5 from celery tuber [4], and a high molecular weight allergen from Brassica napus pollen [5].

What is timothy grass allergy

These allergens are glycoproteins and were originally thought to bind human IgE exclusively via their N-liked glycan moieties. However, recombinant Phl p 4 expressed in Escherichia coli bound IgE of almost every sera of nPhl p 4-sensitized patients [3].

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Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01565 FAD binding domain CL0077 PCMH-like FAD binding
PF08031 Berberine and berberine love CL0277 FAD-linked oxidase C-terminal domain superfamily

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

What is timothy grass allergy

[top]

Allergens from this family

The first identified allergen from this family was BG60 from Bermuda grass pollen [2]. Homology to BBEs was also found for Phl p 4 from timothy grass [3], Api g 5 from celery tuber [4], and a high molecular weight allergen from Brassica napus pollen [5].

What is timothy grass allergy

These allergens are glycoproteins and were originally thought to bind human IgE exclusively via their N-liked glycan moieties. However, recombinant Phl p 4 expressed in Escherichia coli bound IgE of almost every sera of nPhl p 4-sensitized patients [3].

[top]

Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF01565 FAD binding domain CL0077 PCMH-like FAD binding
PF08031 Berberine and berberine love CL0277 FAD-linked oxidase C-terminal domain superfamily

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

What is timothy grass allergy


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