What is skin allergy symptom

In rare cases, an allergy can lead to a severe allergic reaction, called anaphylaxis or anaphylactic shock, which can be life threatening.

This affects the whole body and usually develops within minutes of exposure to something you’re allergic to.

Signs of anaphylaxis include any of the symptoms above, as well as:

Anaphylaxis is a medical emergency that requires immediate treatment.

Read more about anaphylaxis for information about what to do if it occurs.

Sheet final reviewed: 22 November 2018
Next review due: 22 November 2021

8.00 Skin Disorders

A. What skin disorders do we assess with these listings?

We use these listings to assess skin disorders that may result from hereditary, congenital, or acquired pathological processes. The kinds of impairments covered by these listings are: Ichthyosis, bullous diseases, chronic infections of the skin or mucous membranes, dermatitis, hidradenitis suppurativa, genetic photosensitivity disorders, and burns.

B. What documentation do we need?

What is skin allergy symptom

When we assess the existence and severity of your skin disorder, we generally need information about the onset, duration, frequency of flare-ups, and prognosis of your skin disorder; the location, size, and appearance of lesions; and, when applicable, history of exposure to toxins, allergens, or irritants, familial incidence, seasonal variation, stress factors, and your ability to function exterior of a highly protective environment.

To confirm the diagnosis, we may need laboratory findings (for example, results of a biopsy obtained independently of Social Security disability evaluation or blood tests) or evidence from other medically acceptable methods consistent with the prevailing state of medical knowledge and clinical practice.

C. How do we assess the severity of your skin disorder(s)?

We generally base our assessment of severity on the extent of your skin lesions, the frequency of flare-ups of your skin lesions, how your symptoms (including pain) limit you, the extent of your treatment, and how your treatment affects you.

1. Extensive skin lesions.

Extensive skin lesions are those that involve multiple body sites or critical body areas, and result in a extremely serious limitation. Examples of extensive skin lesions that result in a extremely serious limitation include but are not limited to:

a. Skin lesions that interfere with the motion of your joints and that extremely seriously limit your use of more than one extremity; that is, two upper extremities, two lower extremities, or one upper and one lower extremity.


Skin lesions on the palms of both hands that extremely seriously limit your ability to do fine and gross motor movements.

What is skin allergy symptom

c. Skin lesions on the soles of both feet, the perineum, or both inguinal areas that extremely seriously limit your ability to ambulate.

2. Frequency of flare-ups.

If you own skin lesions, but they do not meet the requirements of any of the listings in this body system, you may still own an impairment that prevents you from doing any gainful activity when we consider your condition over time, especially if your flare-ups result in extensive skin lesions, as defined in C1 of this section.

Therefore, if you own frequent flare-ups, we may discover that your impairment(s) is medically equal to one of these listings even though you own some periods during which your condition is in remission. We will consider how frequent and serious your flare-ups are, how quickly they resolve, and how you function between flare-ups to determine whether you own been unable to do any gainful activity for a continuous period of at least 12 months or can be expected to be unable to do any gainful activity for a continuous period of at least 12 months. We will also consider the frequency of your flare-ups when we determine whether you own a severe impairment and when we need to assess your residual functional capacity.

3. Symptoms (including pain).

Symptoms (including pain) may be significant factors contributing to the severity of your skin disorder(s). We assess the impact of symptoms as explained in §§ 404.1521, 404.1529, 416.921, and 416.929 of this chapter.

4. Treatment.

We assess the effects of medication, therapy, surgery, and any other form of treatment you get when we determine the severity and duration of your impairment(s).

Skin disorders frequently reply to treatment; however, response to treatment can vary widely, with some impairments becoming resistant to treatment. Some treatments can own side effects that can in themselves result in limitations.

a. We assess the effects of continuing treatment as prescribed by determining if there is improvement in the symptoms, signs, and laboratory findings of your disorder, and if you experience side effects that result in functional limitations. To assess the effects of your treatment, we may need information about:


The treatment you own been prescribed (for example, the type, dosage, method, and frequency of istration of medication or therapy);

ii. Your response to the treatment;

iii. Any adverse effects of the treatment; and

iv. The expected duration of the treatment.

b. Because treatment itself or the effects of treatment may be temporary, in most cases sufficient time must elapse to permit us to assess the impact and expected duration of treatment and its side effects. Except under 8.07 and 8.08, you must follow continuing treatment as prescribed for at least 3 months before your impairment can be sure to meet the requirements of a skin disorder listing.

What is skin allergy symptom

(See 8.00H if you are not undergoing treatment or did not own treatment for 3 months.) We consider your specific response to treatment when we assess the overall severity of your impairment.

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D. How do we assess impairments that may affect the skin and other body systems?

When your impairment affects your skin and has effects in other body systems, we first assess the predominant feature of your impairment under the appropriate body system. Examples include, but are not limited to the following.

1. Tuberous sclerosis primarily affects the brain.

What is skin allergy symptom

The predominant features are seizures, which we assess under the neurological listings in 11.00, and developmental delays or other mental disorders, which we assess under the mental disorders listings in 12.00.

2. Malignant tumors of the skin (for example, malignant melanomas) are cancers, or neoplastic diseases, which we assess under the listings in 13.00.

3. Autoimmune disorders and other immune system disorders (for example, systemic lupus erythematosus (SLE), scleroderma, human immunodeficiency virus (HIV) infection, and Sjögren’s syndrome) often involve more than one body system. We first assess these disorders under the immune system disorders listings in 14.00.

We assess SLE under 14.02, scleroderma under 14.04, Sjögren’s syndrome under 14.10, and HIV infection under 14.11.

4. Disfigurement or deformity resulting from skin lesions may result in loss of sight, hearing, lecture, and the ability to chew (mastication). We assess these impairments and their effects under the special senses and lecture listings in 2.00 and the digestive system listings in 5.00. Facial disfigurement or other physical deformities may also own effects we assess under the mental disorders listings in 12.00, such as when they affect mood or social functioning.

E. How do we assess genetic photosensitivity disorders?

1. Xeroderma pigmentosum (XP). When you own XP, your impairment meets the requirements of 8.07A if you own clinical and laboratory findings showing that you own the disorder. (See 8.00E3.) People who own XP own a lifelong hypersensitivity to every forms of ultraviolet light and generally lead extremely restricted lives in highly protective environments in order to prevent skin cancers from developing. Some people with XP also experience problems with their eyes, neurological problems, mental disorders, and problems in other body systems.

2. Other genetic photosensitivity disorders.

Other genetic photosensitivity disorders may vary in their effects on diverse people, and may not result in an inability to engage in any gainful activity for a continuous period of at least 12 months. Therefore, if you own a genetic photosensitivity disorder other than XP (established by clinical and laboratory findings as described in 8.00E3), you must show that you own either extensive skin lesions or an inability to function exterior of a highly protective environment to meet the requirements of 8.07B.

You must also show that your impairment meets the duration requirement.

By inability to function exterior of a highly protective environment we mean that you must avoid exposure to ultraviolet light (including sunlight passing through windows and light from unshielded fluorescent bulbs), wear protective clothing and eyeglasses, and use opaque wide spectrum sunscreens in order to avoid skin cancer or other serious effects. Some genetic photosensitivity disorders can own extremely serious effects in other body systems, especially special senses and lecture (2.00), neurological (11.00), mental (12.00), and neoplastic (13.00). We will assess the predominant feature of your impairment under the appropriate body system, as explained in 8.00D.

3. Clinical and laboratory findings.

a. General. We need documentation from an acceptable medical source to establish that you own a medically determinable impairment. In general, we must own evidence of appropriate laboratory testing showing that you own XP or another genetic photosensitivity disorder. We will discover that you own XP or another genetic photosensitivity disorder based on a report from an acceptable medical source indicating that you own the impairment, supported by definitive genetic laboratory studies documenting appropriate chromosomal changes, including abnormal DNA repair or another DNA or genetic abnormality specific to your type of photosensitivity disorder.

b. What we will accept as medical evidence instead of the actual laboratory report. When we do not own the actual laboratory report, we need evidence from an acceptable medical source that includes appropriate clinical findings for your impairment and that is persuasive that a positive diagnosis has been confirmed by appropriate laboratory testing at some time prior to our evaluation. To be persuasive, the report must state that the appropriate definitive genetic laboratory study was conducted and that the results confirmed the diagnosis. The report must be consistent with other evidence in your case record.

F. How do we assess burns?

Electrical, chemical, or thermal burns frequently affect other body systems; for example, musculoskeletal, special senses and lecture, respiratory, cardiovascular, renal, neurological, or mental.

Consequently, we assess burns the way we assess other disorders that can affect the skin and other body systems, using the listing for the predominant feature of your impairment. For example, if your soft tissue injuries are under continuing surgical management (as defined in 1.00M), we will assess your impairment under 1.08. However, if your burns do not meet the requirements of 1.08 and you own extensive skin lesions that result in a extremely serious limitation (as defined in 8.00C1) that has lasted or can be expected to final for a continuous period of at least 12 months, we will assess them under 8.08.

G. How do we determine if your skin disorder(s) will continue at a disabling level of severity in order to meet the duration requirement?

What is skin allergy symptom

For every of these skin disorder listings except 8.07 and 8.08, we will discover that your impairment meets the duration requirement if your skin disorder results in extensive skin lesions that persist for at least 3 months despite continuing treatment as prescribed. By persist, we mean that the longitudinal clinical record shows that, with few exceptions, your lesions own been at the level of severity specified in the listing.

For 8.07A, we will presume that you meet the duration requirement. For 8.07B and 8.08, we will consider every of the relevant medical and other information in your case record to determine whether your skin disorder meets the duration requirement.

H. How do we assess your skin disorder(s) if your impairment does not meet the requirements of one of these listings?

1. These listings are only examples of common skin disorders that we consider severe enough to prevent you from engaging in any gainful activity. For most of these listings, if you do not own continuing treatment as prescribed, if your treatment has not lasted for at least 3 months, or if you do not own extensive skin lesions that own persisted for at least 3 months, your impairment cannot meet the requirements of these skin disorder listings.

(This provision does not apply to 8.07 and 8.08.) However, we may still discover that you are disabled because your impairment(s) meets the requirements of a listing in another body system or medically equals the severity of a listing. (See §§ 404.1526 and 416.926 of this chapter.) We may also discover you disabled at the final step of the sequential evaluation process.

2. If you own not received ongoing treatment or do not own an ongoing relationship with the medical community despite the existence of a severe impairment(s), or if your skin lesions own not persisted for at least 3 months but you are undergoing continuing treatment as prescribed, you may still own an impairment(s) that meets a listing in another body system or that medically equals a listing.

If you do not own an impairment(s) that meets or medically equals a listing, we will assess your residual functional capacity and proceed to the fourth and, if necessary, the fifth step of the sequential evaluation process in §§ 404.1520 and 416.920 of this chapter. When we decide whether you continue to be disabled, we use the rules in §§ 404.1594 and 416.994 of this chapter.

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8.01 Category of Impairments, Skin Disorders

8.02 Ichthyosis, with extensive skin lesions that persist for at least 3 months despite continuing treatment as prescribed.

8.03 Bullous disease (for example, pemphigus, erythema multiforme bullosum, epidermolysis bullosa, bullous pemphigoid, dermatitis herpetiformis), with extensive skin lesions that persist for at least 3 months despite continuing treatment as prescribed. .

8.04 Chronic infections of the skin or mucous membranes, with extensive fungating or extensive ulcerating skin lesions that persist for at least 3 months despite continuing treatment as prescribed.

8.05 Dermatitis (for example, psoriasis, dyshidrosis, atopic dermatitis, exfoliative dermatitis, allergic contact dermatitis), with extensive skin lesions that persist for at least 3 months despite continuing treatment as prescribed.

8.06 Hidradenitis suppurativa, with extensive skin lesions involving both axillae, both inguinal areas or the perineum that persist for at least 3 months despite continuing treatment as prescribed.

8.07 Genetic photosensitivity disorders, established as described in 8.00E.

A. Xeroderma pigmentosum. Consider the individual disabled from birth.

B. Other genetic photosensitivity disorders, with:

1. Extensive skin lesions that own lasted or can be expected to final for a continuous period of at least 12 months,



Inability to function exterior of a highly protective environment for a continuous period of at least 12 months (see 8.00E2).

8.08Burns, with extensive skin lesions that own lasted or can be expected to final for a continuous period of at least 12 months (see 8.00F).

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People who suffer itching with no clear cause may own previously unrecognized immune system defects. In a little study of such patients, researchers from the Middle for the Study of Itch at Washington University School of Medicine in St.

Louis identified immune system irregularities that may immediate the urge to scratch.

The findings are reported in the May issue of The Journal of the American Academy of Dermatology.

“As doctors, we throw things love antihistamines, ointments and lotions at patients who suffer chronic itching, but if there is something profoundly abnormal about the immune system — as it appears there is — then we can’t solve the itching until we address those underlying causes,” said principal investigator Brian S. Kim, MD, an assistant professor of medicine in the Division of Dermatology.

What is skin allergy symptom

“The immune system needs to be in balance, and we hope to discover ways to restore that balance in patients with this extremely debilitating condition.”

The researchers took blood samples and skin biopsies from a little sample of patients — only four are reported in the study — to glance for immune problems. They found “an incredible quantity of dysfunction,” Kim said, adding that he has seen similar defects in numerous additional patients not included in the current study.

The four patients researchers zeroed in on were ages 75 to 90. In blood samples, three of those four had high levels of the protein IgE — an immunoglobulin that is a marker of inflammation.

Immunoglobulins are antibodies deployed by the immune system to fight infections. Elevated levels of IgE often are seen in patients with allergies.

The researchers also noted extremely low levels of an immunoglobulin known as IgG; abnormally low counts of a type of immune cell called a CD8 T-cell; and an elevated number of immune cells called eosinophils, which are markers of allergic inflammation.

“Curiously, none of these patients had any history of allergic disorders,” Kim said.

“We often see similarly high counts of eosinophils in patients with eczema, but the patients we studied didn’t own eczema. They didn’t even own a rash. Only itching.”

Kim explained that dermatologists frequently take skin biopsies when a patient has a rash, but with chronic itching of unknown origin, which doctors call chronic idiopathic pruritis, there is nothing evident to biopsy.

The study’s first author, Amy Xu, a medical student in Kim’s lab, said most patients with this type of unexplained, chronic itching tend to be older and develop itching problems later in life.

“It may be caused by some sort of wear and tear on the immune system,” Xu said.

Because of the little number of patients in the study, it’s too soon to draw firm conclusions, but the itching may be an indication that something else in the body is going incorrect, Kim said.

“We own begun working on a mouse model in which the animals own similar defects,” he said.

“We desire to study whether these changes in the immune system create only itching or whether they could be signs that some other problem is present.”

Washington University School of Medicine’s 2,100 employed and volunteer faculty physicians also are the medical staff of Barnes-Jewish and St. Louis Children’s hospitals. The School of Medicine is one of the leading medical research, teaching and patient-care institutions in the nation, currently ranked sixth in the nation by U.S. News & World Report. Through its affiliations with Barnes-Jewish and St. Louis Children’s hospitals, the School of Medicine is linked to BJC HealthCare.

Originally published by the School of Medicine

First author Amy Xu and principal investigator Brian S.

Kim, MD, found that immune system defects may assist explain chronic itching in some patients. (Photo: Robert Boston/School of Medicine)

In most cases, people with allergies develop mild to moderate symptoms, such as watery eyes, a runny nose or a rash. But sometimes, exposure to an allergen can cause a life-threatening allergic reaction known as anaphylaxis. This severe reaction happens when an over-release of chemicals puts the person into shock.

Allergies to food, insect stings, medications and latex are most frequently associated with anaphylaxis.

A second anaphylactic reaction, known as a biphasic reaction, can happen as endless as 12 hours after the initial reaction.

Call 911 and get to the nearest emergency facility at the first sign of anaphylaxis, even if you own already istered epinephrine, the drug used to treat severe allergic reactions.

Just because an allergic person has never had an anaphylactic reaction in the past to an offending allergen, doesn’t mean that one won’t happen in the future. If you own had an anaphylactic reaction in the past, you are at risk of future reactions.

ON THIS PAGE: You will discover out more about body changes and other things that can signal a problem that may need medical care. Use the menu to see other pages.

NETs can be discovered for numerous diverse reasons because there is no single set of common symptoms. In its early stages, a NET often causes no symptoms and may only be detected during an unrelated x-ray or surgery for another condition.

If a person with a NET has symptoms, those symptoms may be associated with the size and/or location of the tumor or with the release of hormones, such as carcinoid syndrome.

If you are concerned about any changes you experience, please talk with your doctor. Your doctor will enquire how endless and how often you’ve been experiencing the symptom(s), in addition to other questions. This is to assist figure out the cause of the problem, called a diagnosis.

Symptoms of a NET

Depending on the type of NET, a person may experience the following tumor-related symptoms or signs:

General cancer symptoms:

  1. Loss of appetite

  2. Fatigue

  3. Unexplained weight loss

Symptoms related to the tumor size and/or location:

  • Persistent pain in a specific area

  • Thickening or a lump in any part of the body

  • Nausea or vomiting

    1. Jaundice, which is the yellowing of the skin and whites of the eyes

    2. A cough or hoarseness that does not go away

    3. Changes in bowel or bladder habits

    4. Unusual bleeding or discharge

    Symptoms related to the release of hormones:

    1. Anxiety

    2. Diarrhea

    3. Hypoglycemia, which is a low level of glucose in the blood.

      It causes fatigue, nervousness and shakiness, dizziness or light-headedness, sweating, seizures, and fainting.

    4. Gastric ulcer disease

    5. Facial flushing, generally without sweating

    6. Hyperglycemia, which is a high level of glucose in the blood. Glucose is a sugar that is converted into energy by the body. Hyperglycemia causes frequent urination, increased thirst, and increased hunger.

    7. Skin rash

    8. Confusion

    9. Some people also experience nutritional deficiencies before a diagnosis, such as niacin and protein deficiency.

      Others develop this symptom later.

    For symptoms related to a specific type of NET, visit its individual section (see the Introduction for a list.)

    Carcinoid syndrome

    Carcinoid syndrome is the classic example of a sign of a functional NET. It occurs most commonly in people with little intestine and lung NETs that own spread to another part of the body, called metastatic. In carcinoid syndrome, serotonin is produced by the tumor and can cause 1 or more of the following symptoms or signs. Serotonin is most easily and reliably measured in the urine, when it gets converted into 5-hydroxyindoleacetic acid (5-HIAA), and it is measured with a 24-hour urine collection test.

    It is significant to note that these symptoms alone are not enough to diagnose carcinoid syndrome. Blood or urine tests to measure for suspected hormones are also needed to make a diagnosis. Not every people with a NET develop carcinoid syndrome.

    1. High blood pressure and significant fluctuations in blood pressure

    2. Facial flushing, which is redness and a warm feeling over the face

    3. Unexplained weight gain

    4. Weakness

    5. Diarrhea

    6. Shortness of breath

    7. Fast heartbeat

    8. Heart murmur

    9. Wheezing or asthma-like symptoms

    10. Carcinoid heart disease, which is a scarring of the heart valves caused by serotonin.

    Stress, strenuous exercise, and drinking alcohol may make these symptoms worse.

    Some foods may also trigger the symptoms of carcinoid syndrome, including foods high in:

    1. Amines, such as aged cheeses, yeast extracts, tofu, sauerkraut, and smoked fish and meats

    2. Serotonin, such as walnuts, pecans, plantains, bananas, and tomatoes

    Carcinoid crisis

    Carcinoid crisis is a term used when people experience severe, sudden symptoms of carcinoid syndrome, generally in times of extreme stress, such as surgery. Carcinoid crisis primarily includes serious fluctuations in blood pressure and heart rate.

    Carcinoid crisis is the most serious and life-threatening complication of carcinoid syndrome. It is generally recommended that patients get intravenous octreotide (Sandostatin), a medication that helps control the production of hormones, before a planned surgery. Octreotide is also used to treat carcinoid crisis.

    Managing symptoms

    If a NET is diagnosed, relieving symptoms remains an significant part of your care and treatment. This may be called palliative care or supportive care. It is often started soon after diagnosis and continued throughout treatment. Under is information on how some of the symptoms of a NET can be managed.

    Be certain to talk with your health care team about the symptoms you experience, including any new symptoms or a change in symptoms.

    1. Wheezing. Ask your doctor about the use of a bronchodilator, a medication that relaxes the muscles in the lungs to make breathing easier.

    2. Facial flushing. Avoid stress. Enquire your doctor about specific substances and foods, including alcohol, that can cause facial flushing so you can avoid them.

      Somatostatin analogs, love octreotide and lanreotide (Somatuline Depot), can assist. Read more about somatostatin analogs in Types of Treatment.

    3. Diarrhea.

      What is skin allergy symptom

      There can be numerous causes of diarrhea in people with a NET. If your diarrhea is caused by carcinoid syndrome, somatostatin analogs (octreotide and lanreotide) and telotristat ethyl (Xermelo) can assist. In addition, there are other medications that can assist control diarrhea, depending on what is causing it. Enquire your doctor for specific recommendations.

    4. Heart valve problems. Tell your doctor immediately if you ponder you may own a problem with your heart. Signs of this problem include difficulty breathing and becoming easily tired during exercise.

    Learn more about managing common cancer symptoms and treatment side effects.

    The next section in this guide is Diagnosis.

    It explains what tests may be needed to study more about the cause of the symptoms. Use the menu to select a diverse section to read in this guide.

    Main allergy symptoms

    Common symptoms of an allergic reaction include:

    1. tummy pain, feeling ill, vomiting or diarrhoea
    2. sneezing and an itchy, runny or blocked nose (allergic rhinitis)
    3. wheezing, chest tightness, shortness of breath and a cough
    4. a raised, itchy, red rash (hives)
    5. itchy, red, watering eyes (conjunctivitis)
    6. swollen lips, tongue, eyes or face
    7. dry, red and cracked skin

    The symptoms vary depending on what you’re allergic to and how you come into contact with it.

    For example, you may have a runny nose if exposed to pollen, develop a rash if you own a skin allergy, or feel sick if you eat something you’re allergic to.

    See your GP if you or your kid might own had an allergic reaction to something. They can assist determine whether the symptoms are caused by an allergy or another condition.

    Read more about diagnosing allergies.