What is latex fruit allergy

Blanco et al. conducted a prospective study in their outpatient clinic in 25 patients diagnosed with latex allergy, published in 1994.They used a clinical questionnaire, skin-prick tests, skin test with a latex extract, and identification of entire and specific IgE to assist ascertain clinical characteristics and cross-reactivity. Of the 23 women and 2 men in the study (mean age 33, plus or minus 9 years), 9 (36%) experienced latex-induced reactions characterized by systemic anaphylaxis. In 13 patients (52%), 42 food allergies were identified, and 23 included systemic anaphylaxis.

What is latex fruit allergy

Avocado (9), chestnut (9), banana (7), kiwi (5), and papaya (3) were the most common foods to cause hypersensitivities. The researchers concluded that their little study supported the reality of a “latex-fruit syndrome.”3

Another study aimed to characterize the cross-reactivity of latex and foods and assess clinical significance. Beezhold et al. examined 47 patients allergic to latex and 46 nonallergic controls. The investigators found immunologic reactivity to foods to be prevalent (33 latex-allergic patients and seven controls), with 27% of food skin-prick tests positive in the latex-allergic group.

What is latex fruit allergy

In addition, clinical symptoms were linked to 27% of positive skin-prick tests. Among the 17 patients who displayed clinical allergies to at least one food, 14 showed local sensitivity reactions, with anaphylaxis noted in 11. Avocado (53%), potato (40%), banana (38%), tomato (28%), chestnut (28%), and kiwi (17%) were the foods most frequently cited for provoking a skin test reaction. The authors observed extensive cross-reactivity between latex sensitivity and specific foods, with potatoes and tomatoes reported for the first time.4

In 1997, Brehler et al.

What is latex fruit allergy

studied serum samples from 136 patients whose immediate hypersensitivity to latex proteins was clinically observable and documented. The samples were assessed for IgE antibodies against several fruits, with fruit-specific IgE antibodies recorded in 69.1%. Radioallergosorbent (RAST) -inhibition tests yielded the recognition of cross-reacting IgE antibodies in latex and multiple fruit allergens: avocado, banana, chestnut, fig, kiwi, mango, melon, papaya, passion fruit, peach, pineapple, and tomato. The investigators recorded 112 intolerance reactions and noted that 42.5% of their patients reported allergic symptoms after consuming these fruits.

Fruit-specific IgE antibodies were detected in only 32.1% of these patients, suggesting to the researchers that serologic tests were suboptimal in forecasting food hypersensitivities in patients who are allergic to latex.5


Cross-reactivity with banana

Mäkinen-Kiljunen studied 47 patients to investigate banana allergy in patients with latex allergy in 1994, measuring latex-, banana-, and pollen-specific (birch, timothy, and mugwort) IgE. Thirty-one patients were also given skin-prick tests with banana and were queried about reactions after consuming bananas.

Of the 47 sera samples, latex RAST results were positive in 31 and banana RAST results in 26.

What is latex fruit allergy

RAST results from latex and banana were correlated (25 of the 31 latex RAST-positive samples were also banana RAST-positive), but not with pollen. Sixteen of the 31 patients who ate banana reported symptoms, and 11 of the 31 patients given the banana skin-prick test showed positive results. The author confirmed the cross-reactivity of IgE antibodies for latex and banana, identifying for the first time a structurally similar antigen/allergen as at least one antigen from banana fused with an antigen from latex in crossed-line immunoelectrophoresis.6

In 1998, Mikkola et al. investigated whether proteins similar to hevein, a major natural rubber latex allergen, are present in banana and account for cross-reactivity between these botanicals.

Immunoblotting revealed that 9 of 15 sera from latex-allergic patients with IgE to hevein also bound to 32- and 33-kd banana proteins. Studies using ELISA [enzyme-linked immunosorbent assay] showed that the common presentation of hypersensitivity to banana among patients allergic to latex could be attributed to cross-reacting IgE antibodies binding to epitopes in hevein and in the then-newly identified hevein-like endochitinase found in banana.7

AF069: Bet v 1 family

Links to Pfam

Family-defining Pfam domains (at least one of these domains is present in each family member):

Pfam domain Pfam clan
PF00407 Pathogenesis-related protein Bet v I family CL0209 Bet V 1 love

References

  • Chen JY, Dai XF:
    Cloning and characterization of the Gossypium hirsutum major latex protein gene and functional analysis in Arabidopsis thaliana.
    Planta 2010, 231, 861-73.

    [PubMed][Full Text]

  • Guhsl EE, Hofstetter G, Hemmer W, Ebner C, Vieths S, Vogel L, Breiteneder H, Radauer C:
    Vig r 6, the cytokinin-specific binding protein from mung bean (Vigna radiata) sprouts, cross-reacts with Bet v 1-related allergens and binds IgE from birch pollen allergic patients’ sera.
    Mol Nutr Food Res 2014, 58, 625-34. [PubMed][Full Text]
  • Fernandes H, Michalska K, Sikorski M, Jaskolski M:
    Structural and functional aspects of PR-10 proteins.
    FEBS J 2013, 280, 1169-99. [PubMed][Full Text]
  • Vieths S, Scheurer S, Ballmer-Weber B:
    Current understanding of cross-reactivity of food allergens and pollen.
    Ann N Y Acad Sci 2002, 964, 47-68.

    [PubMed]

  • Radauer C, Lackner P, Breiteneder H:
    The Bet v 1 fold: an ancient, versatile scaffold for binding of large, hydrophobic ligands.
    BMC Evol Biol 2008, 8, 286. [PubMed][Full Text]
  • Michalska K, Fernandes H, Sikorski M, Jaskolski M:
    Crystal structure of Hyp-1, a St. John’s wort protein implicated in the biosynthesis of hypericin.
    J Struct Biol 2010, 169, 161-71. [PubMed][Full Text]
  • Osmark P, Boyle B, Brisson N:
    Sequential and structural homology between intracellular pathogenesis-related proteins and a group of latex proteins.
    Plant Mol Biol 1998, 38, 1243-6.

    [PubMed]

  • Seutter von Loetzen C, Hoffmann T, Hartl MJ, Schweimer K, Schwab W, Rosch P, Hartl-Spiegelhauer O:
    Secret of the major birch pollen allergen Bet v 1: identification of the physiological ligand.
    Biochem J 2014, 457, 379-90.

    What is latex fruit allergy

    [PubMed][Full Text]

  • Park CJ, Kim KJ, Shin R, Park JM, Shin YC, Paek KH:
    Pathogenesis-related protein 10 isolated from boiling pepper functions as a ribonuclease in an antiviral pathway.
    Plant J 2004, 37, 186-98. [PubMed]
  • Sliwiak J, Dolot R, Michalska K, Szpotkowski K, Bujacz G, Sikorski M, Jaskolski M:
    Crystallographic and CD probing of ligand-induced conformational changes in a plant PR-10 protein.
    J Struct Biol 2016, 193, 55-66. [PubMed][Full Text]
  • Markovic-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H:
    Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier.
    J Mol Biol 2003, 325, 123-33.

    [PubMed]

  • D’Avino R, Bernardi ML, Wallner M, Palazzo P, Camardella L, Tuppo L, Alessandri C, Breiteneder H, Ferreira F, Ciardiello MA, Mari A:
    Kiwifruit Act d 11 is the first member of the ripening-related protein family identified as an allergen.
    Allergy 2011, 66, 870-7. [PubMed][Full Text]

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Biochemical properties

Bet v 1-related proteins are widely distributed among vascular plants. The family was classified by sequence similarity into two large and several little subfamilies showing low levels of sequence identity but conserved structures [1]. The largest of these is the pathogenesis-related protein family PR-10 [2].

The expression of these proteins is either induced by pathogen attack or abiotic stress or developmentally regulated. PR-10 proteins are expressed in high concentrations in reproductive tissues such as pollen, seeds and fruits. The biochemical function of most PR-10 proteins is unknown. For some PR-10 subfamily members an enzymatic function as ribonuclease [3] or oxidative coupling enzyme involved in biosynthesis of secondary metabolites was shown [4]. Love every members of the Bet v 1-family, PR-10 proteins contain a large ligand-binding cavity that can accommodate diverse ligands including plant steroids [5], cytokinins [6] and flavonoids [7]. The other large subfamily is a group of major latex proteins and ripening-related proteins (MLP/RRP) first described in the latex of opium poppy [8].

Their biologic function is unknown, but they appear to own a role in defense against biotic and abiotic stress [9].

Allergens from this family

The major birch pollen allergen, Bet v 1, is a member of the PR-10 family.

What is latex fruit allergy

Closely-related, cross-reactive allergens were found in the pollen of other trees from the order Fagales such as hazel, alder, oak and chestnut. Numerous birch pollen-allergic patients show allergic reactions to various fruits and vegetables, which are caused by IgE cross-reactivity between Bet v 1 and homologous allergens from plant foods [10]. Most Bet v 1-related food allergens were found in members of certain plant families: Rosaceae (apple, pear, rock fruits), Apiaceae (celery, carrot), and Fabaceae (soybean, peanut).

Only two Bet v 1-related allergens were identified exterior the PR-10 subfamily. Vig r 6 is a minor allergen from mung bean and member of the cytokinin-specific binding proteins subfamily, a little subfamily distantly related to the PR-10 group [11]. Act d 11 is a minor kiwifruit allergen belonging to the MLP/RRP subfamily [12].

[top]

Links to Wikipedia

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

This is an exciting question.

Bananas own little amounts of a protein called Chitinase (Chitinase — Wikipedia).

Allergies are almost always from proteins, so Chitinase is probably the culprit. How would you know? Well other sources of Chitinase are kiwi and avocado, so if someone has a problem with bananas, they might own a problem with kiwi/avocado too. Also, for whatever reason, latex.

If someone has a reaction to bananas but “NOT” latex and/or NOT kiwi/avocado, what else? Well there is fructose. I made a video talking about fructose malabsorption on my YouTube channel DorkSideCookies, but the short of it is that some people lack the ability to process fructose and/or lack the ability to process large amounts of fructose.

That wouldn’t be a problem per se, but sending unprocessed sugar directly into the intestines is a excellent way to create a gut flora bloom that can cause the obvious problems love bloating and gas, but can also cause less obvious problems love blocking serotonin production which can cause depression, moodiness, and other mental-related issues.

Personally while I can handle a banana a day (and I do), too numerous strawberries make me ill, so I would discover it unlikely to blame bananas for fructose malabsorption-related issues, but everyone might be diverse.

What is latex fruit allergy

A excellent test to determine possible fructose problems is whether a person can handle chicory root (also known as inulin).

You’ll discover chicory root/inulin laced products in the breakfast aisle labeled generally as “high fiber” or “extra fiber”. Anything with chicory root/inulin will give me a “bad day” within about 3–4 hours of eating it.

There are a variety of other chemicals in bananas obviously, and its theoretically possible to own an allergy (more likely a food intolerance) to those other chemicals, but I’d focus on chitinase first, then fructose second.

Good luck!

WHEREAS, latex allergy patients face a constant threat to their lives from exposure to rubber latex allergens; and

WHEREAS, reactions can be elicited by touching a product containing natural rubber latex, breathing airborne latex proteins, or digesting food prepared using latex gloves; and

WHEREAS, up to six percent of people in the United States own a latex allergy, including up to 17 percent of health care and food service workers, 11 percent of the elderly, and 73 percent of children with spina bifida; and

WHEREAS, latex allergies result in approximately 220 cases of anaphylaxis and 3 deaths per year and is the second most common cause of anaphylaxis in the operating room; and

WHEREAS, patients with a latex allergy may also experience allergic symptoms when eating certain fruits, vegetables, and nuts, including, among other things, bananas, avocados, kiwis, tomatoes, carrots, and chestnuts; and

WHEREAS, there is no cure for a latex allergy, and every exposure increases the sensitivity and severity of the patient’s condition, with distress and rebound reactions for days after exposure; and

WHEREAS, latex allergies can only be prevented by avoiding every latex-related products, which can be found in homes, kid care centers, stores, schools, workplaces, and health care environments, among other places; and

WHEREAS, natural rubber is found in over 40,000 products, including, but not limited to, hair accessories, toys, balloons, school and office supplies, sports equipment, and medical devices, resulting in a daily struggle for latex allergy patients to balance life and work with staying safe and healthy; and

WHEREAS, latex allergies result in a growing number of workers’ compensation claims arising from workplace exposure to products containing natural rubber latex; and

WHEREAS, the Allergy and Asthma Network raises awareness of latex allergies through education and provides support to individuals who own been diagnosed with a latex allergy;

NOW, THEREFORE, I, Ralph S.

Northam, do hereby recognize October 6-12, 2019, as LATEX ALLERGY AWARENESS WEEK in our COMMONWEALTH OF VIRGINIA, and I call this observance to the attention of every our citizens.

[top]

Biochemical properties

Bet v 1-related proteins are widely distributed among vascular plants.

What is latex fruit allergy

The family was classified by sequence similarity into two large and several little subfamilies showing low levels of sequence identity but conserved structures [1]. The largest of these is the pathogenesis-related protein family PR-10 [2]. The expression of these proteins is either induced by pathogen attack or abiotic stress or developmentally regulated. PR-10 proteins are expressed in high concentrations in reproductive tissues such as pollen, seeds and fruits. The biochemical function of most PR-10 proteins is unknown. For some PR-10 subfamily members an enzymatic function as ribonuclease [3] or oxidative coupling enzyme involved in biosynthesis of secondary metabolites was shown [4].

Love every members of the Bet v 1-family, PR-10 proteins contain a large ligand-binding cavity that can accommodate diverse ligands including plant steroids [5], cytokinins [6] and flavonoids [7]. The other large subfamily is a group of major latex proteins and ripening-related proteins (MLP/RRP) first described in the latex of opium poppy [8]. Their biologic function is unknown, but they appear to own a role in defense against biotic and abiotic stress [9].

Allergens from this family

The major birch pollen allergen, Bet v 1, is a member of the PR-10 family. Closely-related, cross-reactive allergens were found in the pollen of other trees from the order Fagales such as hazel, alder, oak and chestnut.

Numerous birch pollen-allergic patients show allergic reactions to various fruits and vegetables, which are caused by IgE cross-reactivity between Bet v 1 and homologous allergens from plant foods [10]. Most Bet v 1-related food allergens were found in members of certain plant families: Rosaceae (apple, pear, rock fruits), Apiaceae (celery, carrot), and Fabaceae (soybean, peanut). Only two Bet v 1-related allergens were identified exterior the PR-10 subfamily. Vig r 6 is a minor allergen from mung bean and member of the cytokinin-specific binding proteins subfamily, a little subfamily distantly related to the PR-10 group [11].

Act d 11 is a minor kiwifruit allergen belonging to the MLP/RRP subfamily [12].

[top]

Links to Wikipedia

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

This is an exciting question.

Bananas own little amounts of a protein called Chitinase (Chitinase — Wikipedia). Allergies are almost always from proteins, so Chitinase is probably the culprit. How would you know? Well other sources of Chitinase are kiwi and avocado, so if someone has a problem with bananas, they might own a problem with kiwi/avocado too.

Also, for whatever reason, latex.

If someone has a reaction to bananas but “NOT” latex and/or NOT kiwi/avocado, what else? Well there is fructose. I made a video talking about fructose malabsorption on my YouTube channel DorkSideCookies, but the short of it is that some people lack the ability to process fructose and/or lack the ability to process large amounts of fructose.

That wouldn’t be a problem per se, but sending unprocessed sugar directly into the intestines is a excellent way to create a gut flora bloom that can cause the obvious problems love bloating and gas, but can also cause less obvious problems love blocking serotonin production which can cause depression, moodiness, and other mental-related issues.

Personally while I can handle a banana a day (and I do), too numerous strawberries make me ill, so I would discover it unlikely to blame bananas for fructose malabsorption-related issues, but everyone might be diverse.

A excellent test to determine possible fructose problems is whether a person can handle chicory root (also known as inulin).

You’ll discover chicory root/inulin laced products in the breakfast aisle labeled generally as “high fiber” or “extra fiber”. Anything with chicory root/inulin will give me a “bad day” within about 3–4 hours of eating it.

There are a variety of other chemicals in bananas obviously, and its theoretically possible to own an allergy (more likely a food intolerance) to those other chemicals, but I’d focus on chitinase first, then fructose second.

Good luck!

WHEREAS, latex allergy patients face a constant threat to their lives from exposure to rubber latex allergens; and

WHEREAS, reactions can be elicited by touching a product containing natural rubber latex, breathing airborne latex proteins, or digesting food prepared using latex gloves; and

WHEREAS, up to six percent of people in the United States own a latex allergy, including up to 17 percent of health care and food service workers, 11 percent of the elderly, and 73 percent of children with spina bifida; and

WHEREAS, latex allergies result in approximately 220 cases of anaphylaxis and 3 deaths per year and is the second most common cause of anaphylaxis in the operating room; and

WHEREAS, patients with a latex allergy may also experience allergic symptoms when eating certain fruits, vegetables, and nuts, including, among other things, bananas, avocados, kiwis, tomatoes, carrots, and chestnuts; and

WHEREAS, there is no cure for a latex allergy, and every exposure increases the sensitivity and severity of the patient’s condition, with distress and rebound reactions for days after exposure; and

WHEREAS, latex allergies can only be prevented by avoiding every latex-related products, which can be found in homes, kid care centers, stores, schools, workplaces, and health care environments, among other places; and

WHEREAS, natural rubber is found in over 40,000 products, including, but not limited to, hair accessories, toys, balloons, school and office supplies, sports equipment, and medical devices, resulting in a daily struggle for latex allergy patients to balance life and work with staying safe and healthy; and

WHEREAS, latex allergies result in a growing number of workers’ compensation claims arising from workplace exposure to products containing natural rubber latex; and

WHEREAS, the Allergy and Asthma Network raises awareness of latex allergies through education and provides support to individuals who own been diagnosed with a latex allergy;

NOW, THEREFORE, I, Ralph S.

Northam, do hereby recognize October 6-12, 2019, as LATEX ALLERGY AWARENESS WEEK in our COMMONWEALTH OF VIRGINIA, and I call this observance to the attention of every our citizens.


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