What is cladosporium allergy

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81101

Grant, C.R.; Rees, T.A.

Sorbitol metabolism by apple seedlings

Phytochemistry

20

1505-1511

1981

Laminaria digitata

brenda

94714

Singh, M.; Scrutton, N.S.; Scrutton, M.C.

NADPH generation in Aspergillus nidulans: is the mannitol cycle involved?

J. Gen. Microbiol.

134

643-654

1988

Aspergillus nidulans

3141571

brenda

94717

Hult, K.; Veide, A.; Gatenbeck, S.

The distribution of the NADPH regenerating mannitol cycle among fungal species

Arch. Microbiol.

128

253-255

1980

Alternaria alternata, Botrytis cinerea, Ceratocystis multiannulata, Cladosporium cladosporioides, Fusarium graminearum, Neurospora crassa, Penicillium glabrum, Talaromyces islandicus, Thermomyces lanuginosus

6782999

brenda

285854

Stoop, J.M.H.; Mooibroek, H.

Cloning and characterization of NADP-dependent dehydrogenase cDNA from the button mushroom, Agaricus bisporus, and its expression in response to NaCl stress

Appl. Environ. Microbiol.

64

4689-4696

1998

Agaricus bisporus

9835550

brenda

285855

Adachi, O.; Toyama, H.; Matsushita, K.

Crystalline NADP-dependent D-mannitol dehydrogenase from Gluconobacter suboxydans

Biosci. Biotechnol. Biochem.

63

402-407

1999

Gluconobacter oxydans, Gluconobacter oxydans IFO 12528

27393065

brenda

285856

Kulkarni, R.K.

Mannitol metabolism in Lentinus edodes, the shiitake mushroom

Appl. Environ. Microbiol.

56

250-253

1990

Lentinula edodes

16348099

brenda

285858

Martin, F.; Canet, D.; Marchal, J.P.

13C Nuclear magnetic resonance study of mannitol cycle and trehalose synthesis during glucose utilization by the ectomycorrhizal ascomycete Cenococcum graniforme

Plant Physiol.

77

499-502

1985

Cenococcum graniforme

16664085

brenda

285859

Morton, N.; Dickerson, A.G.; Hammond, J.B.W.

Mannitol metabolism in Agaricus bisporus: Purification and properties of mannitol dehydrogenase

J.

Gen. Microbiol.

131

2885-2890

1985

Agaricus bisporus

brenda

285860

Boutelje, J.; Hult, K.; Gatenbeck, S.

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Eur. J. Appl. Microbiol. Biotechnol.

17

7-12

1983

Penicillium chrysogenum

brenda

285861

Niehaus, W.G.; Dilts, R.P.

What is cladosporium allergy

Purification and characterization of mannitol dehydrogenase from Aspergillus parasiticus

J. Bacteriol.

151

243-250

1982

Aspergillus parasiticus

7085559

brenda

285864

Clancy, F.G.; Coffey, M.D.

Polyol dehydrogenases in the rust fungus, Melampsora lini (Ehrenb.) Lev.

J. Gen. Microbiol.

120

85-88

1980

Melampsora lini

brenda

285865

Ruffner, H.P.; Rast, D.; Tobler, H.; Karesch, H.

Purification and properties of mannitol dehydrogenase from Agaricus bisporus sporocarps

Phytochemistry

17

865-868

1978

Agaricus bisporus

brenda

285866

Sasajima, K.; Isono, M.

Polyol dehydrogenases in the soluble part of Acetobacter melanogenum

Agric. Biol. Chem.

32

161-169

1968

Gluconobacter oxydans

brenda

285867

Strobel, G.A.; Kosuge, T.

Polyol metabolism in Diplodia viticola Desm.

Arch. Biochem. Biophys.

109

622-626

1965

Diplodia viticola Desm.

14320506

brenda

285868

Edmundowicz, J.M.; Wriston, J.C.

Mannitol dehydrogenase from Agaricus campestris

J. Biol. Chem.

238

3539-3541

1963

Agaricus campestris

14109183

brenda

285869

Hammond, J.B.W.

Carbohydrate metabolism in Agaricus bisporus: Oxidative pathways in mycelium and sporophore

J. Gen. Microbiol.

102

245-248

1977

Agaricus bisporus

brenda

285870

Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.; Sassoon, J.

The crystallographic structure of the mannitol 2-dehydrogenase NADP+ binary complicated from Agaricus bisporus

J. Biol. Chem.

276

27555-27561

2001

Agaricus bisporus

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Sassoon, J.; Horer, S.; Stoop, J.; Mooibroek, H.; Baumann, U.

Crystallization and preliminary crystallographic analysis of mannitol dehydrogenase (MtDH) from the common mushroom Agaricus bisporus

Acta Crystallogr. Sect. D

57

711-713

2001

Agaricus bisporus

11320313

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654271

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Purification and characterization of a novel mannitol dehydrogenase from a newly isolated strain of Candida magnoliae

Appl. Environ. Microbiol.

69

4438-4447

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Controlling substrate concentration in fed-batch Candida magnoliae culture increases mannitol production

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Purification and characterization of a novel mannitol dehydrogenase from Lactobacillus intermedius

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537-542

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Klimacek, M.; Kavanagh, K.L.; Wilson, D.K.; Nidetzky, B.

Pseudomonas fluorescens mannitol 2-dehydrogenase and the family of polyol-specific long-chain dehydrogenases/reductases: sequence-based classification and analysis of structure-function relationships

Chem. Biol. Interact.

143-144

559-582

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12604242

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656950

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Purification and characterization of mannitol dehydrogenase and identification of the corresponding cDNA from the head blight fungus, Gibberella zeae (Fusarium graminearum)

Phytochemistry

61

791-796

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Fusarium graminearum

12453571

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667280

Sasaki, Y.; Laivenieks, M.; Zeikus, J.G.

Lactobacillus reuteri ATCC 53608 mdh gene cloning and recombinant mannitol dehydrogenase characterization

Appl. Microbiol. Biotechnol.

68

36-41

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15630578

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Schneider, P.B.; Denk, U.; Breitenbach, M.; Richter, K.; Schmid-Grendelmeier, P.; Nobbe, S.; Himly, M.; Mari, A.; Ebner, C.; Simon-Nobbe, B.

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17177674

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NADP-dependent mannitol dehydrogenase, a major allergen of Cladosporium herbarum

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Possible roles for mannitol and mannitol dehydrogenase in the biotrophic plant pathogen Uromyces fabae

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The Hypocrea jecorina (syn. Trichoderma reesei) lxr1 gene encodes a D-mannitol dehydrogenase and is not involved in L-arabinose catabolism

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Crystal structure of the NADP-dependent mannitol dehydrogenase from Cladosporium herbarum: Implications for oligomerisation and catalysis

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What is cladosporium allergy

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Part Description

LP13948-2 Cladosporium herbarum
Cladosporium is one of the most common colonizers of dying and dead plants and also occurs in various soil types, and on food. This mold is frequently found in uncleaned refrigerators, foodstuffs, on moist window frames, in houses with poor ventilation, with straw roofs, and situated in low, damp areas. It has been isolated from fuel tanks, face creams, paints and textiles.

In the allergic population, sensitisation to moulds may vary from 5 to 30%. The wide range of allergenic proteins in C.

herbarum may result in sensitisation and subsequent expression of a range of immune-related diseases. Cladosporium sensitisation is particularly associated with severe or life-threatening asthma. Upper respiratory symptoms happen with exposure to Cladosporium, but asthma symptoms are more prevalent. Cladosporium may also result in allergic bronchopulmonary cladosporiosis. Copyright Copyright © 2006 Phadia AB.Source: ImmunoCap, ImmunoCap

Testing for IgE antibodies may be useful to establish the diagnosis of an allergic disease and to define the allergens responsible for eliciting signs and symptoms.

Testing also may be useful to identify allergens which may be responsible for allergic disease and/or anaphylactic episode, to confirm sensitization to specific allergens prior to beginning immunotherapy, and to investigate the specificity of allergic reactions to insect venom allergens, drugs, or chemical allergens.

Clinical manifestations of immediate hypersensitivity (allergic) diseases are caused by the release of proinflammatory mediators (histamine, leukotrienes, and prostaglandins) from immunoglobulin E (IgE)-sensitized effector cells (mast cells and basophils) when cell-bound IgE antibodies interact with allergen.

In vitro serum testing for IgE antibodies provides an indication of the immune response to allergen(s) that may be associated with allergic disease.

The allergens chosen for testing often depend upon the age of the patient, history of allergen exposure, season of the year, and clinical manifestations.

In individuals predisposed to develop allergic disease(s), the sequence of sensitization and clinical manifestations proceed as follows: eczema and respiratory disease (rhinitis and bronchospasm) in infants and children less than 5 years due to food sensitivity (milk, egg, soy, and wheat proteins) followed by respiratory disease (rhinitis and asthma) in older children and adults due to sensitivity to inhalant allergens (dust mite, mold, and pollen inhalants).

Detection of IgE antibodies in serum (Class 1 or greater) indicates an increased likelihood of allergic disease as opposed to other etiologies and defines the allergens that may be responsible for eliciting signs and symptoms.

The level of IgE antibodies in serum varies directly with the concentration of IgE antibodies expressed as a class score or kU/L.

Testing for IgE antibodies is not useful in patients previously treated with immunotherapy to determine if residual clinical sensitivity exists, or in patients in whom the medical management does not depend upon identification of allergen specificity.

Some individuals with clinically insignificant sensitivity to allergens may own measurable levels of IgE antibodies in serum, and results must be interpreted in the clinical context.

False-positive results for IgE antibodies may happen in patients with markedly elevated serum IgE (>2,500 kU/L) due to nonspecific binding to allergen solid phases.

Homburger HA: Chapter 53: Allergic diseases.

In Clinical Diagnosis and Management by Laboratory Methods. 21st edition. Edited by RA McPherson, MR Pincus. WB Saunders Company, New York, 2007, Part VI, pp 961-971


Searching the Web

Middle East

Table I. Air-borne and allergenic weed pollen grains

Pollen Amaranthus Atriplex Chenopodium Salsola Plantago spp Kochia spp Rumex spp
Country
K.S.A +++
(8,9,10,13) $
+
(10)
+++
(10,11,13)
+++
(10)
+
(10,13)
++
(11)
++
(10,13)
Kuwait NA NA ++
(12,14,15,16)
+++
(12)
+
(16)
NA NA
Qatar NA NA NA NA NA NA NA
Bahrain NA NA NA NA NA NA NA
Oman NA NA NA NA NA NA NA
U.A.E NA NA ++
(17)
NA NA +
(17)
NA
Jordan +
(18)
NA +
(18)
NA +
(18)
NA +
(18)
Turkey NA NA NA NA +
(19)
NA NA
Egypt NA NA NA NA NA NA NA
Iran NA NA ++
(20)
NA NA NA NA
Lebanon NA NA +
(21)
NA NA NA NA
Morocco NA NA NA NA NA NA NA

# NA: No Available Data
$Amaranthus viridis


Table II.

Air-borne and allergenic trees and grasspollen grains

Pollen Prosopis juliflora (Mesquite) Populus deltoides (Cotton wood) Phoenix dactylifera (Date palm) Cynodon dactylon (Bermuda grass) Other Trees Other Grasses Misc. Pollen
Country
K.S.A ++
(10,11,13,22)
++
(11)
+
(13)
+
(10,11)
NA ++
(11)
+
(11,13)
Kuwait ++
(14,15,16,22)
NA NA ++
(12,14,15,23)
NA NA +
(14,15,16)
Qatar NA NA NA NA NA NA NA
Bahrain NA NA NA NA +
(24)
+
(24)
NA
Oman NA NA NA NA NA NA NA
U.A.E ++
(17,22)
++
(17)
+
(17,25)
++
(17)
NA ++
(17)
++
(17)
Jordan NA NA NA NA ++
(18)
+
(18)
+
(18)
Turkey ++
(23)
NA NA NA +
(27)
+++
(27)
++
(19,27)
Egypt NA NA NA NA NA NA NA
Iran NA NA NA NA ++
(20,28,29)
++
(20,28,29)
++
(20,30)
Lebanon NA NA NA +
(31)
NA NA +
(21,31)
Morocco NA NA NA NA NA +
(32)
+
(32)

# NA: No Available Data
Miscellaneous pollen: Acacia, Olea europea, Pinus strobus, Platanus occidentalis, Cupressus arizonica, Lolium multiflorum.


Table III.

Air-borne and allergenic fungalallergens

Fungi Alternaria Aspergillus Cladosporium Penicillium Ulocladium Misc. fungi
Country
K.S.A ++
(11,13,40,41)
+
(41)
+
(13,35,41)
+
(41)
+
(13,41)
+
(13,33,34,39,41) η
Kuwait +
(23,36,42)
+
(23,36)
+
(23,36,42)
+
(23,36)
+
(42)
+
(14,15,23,36, 42)
Qatar +
(43$)
+
(43)
++
(43^^)
+
(43ξ)
+
(43)
NA
Bahrain NA NA NA NA NA +
(24)
Oman NA NA NA NA NA NA
U.A.E NA +
(44)
NA NA NA NA
Jordan +
(45)
+
(45)
++
(45)
+
(45)
+
(45)
+
(45)
Turkey +
(37,46)
+
(37)
++
(37,46)
+
(37)
NA +
(27)
Egypt +
(38$,47$,48)
++
(38,48,49)
+
(38,47^,48,49)
+
(47ξ,48)
+
(38˜,47˜)
+
(48,49)
Iran ++
(29,50)
++
(29,50,51)
++
(29,50,51)
++
(29,50,51)
NA +
(28)
Lebanon NA NA NA NA NA NA
Morocco NA NA NA +
(52)
NA NA

# NA: No Available Data

Miscellaneous fungi: Candida spp.

(23), Helminthosporium spp. (23), molds (14,15,24,26,27)

$Alternaria alternata ^Cladosporium cladosporoides
ηBasidiospores ^^Cladosporium sphaerospermum
ξPenicillium chrysogenum ~Ulocladium tuberculatum

Table IV. Air-borne and allergenic indoor allergens

Fungi Der p 1& Der f 1
Dermatophagoides

(House Dust Mite)
Per a 1
Periplaneta americana

(American Cockroach)
Bla g 1
Blattella germanica

(German Cockroach)
Fel d 1
Felis domesticus

(Cat)
Blo t
Blomia tropicalis

(House Dust Mite)
Bla o
Blatella orientalis
(Oriental Cockroach)
Country
K.S.A ++
(11*^,53*^)
+
(11)
+
(11)
++
(11)
NA NA
Kuwait ++
(12*,14,23,54*)
++
(12)
++
(12,14,54)
+
(54,55)
NA NA
Qatar ++
(56*^)
NA +
(56)
NA NA NA
Bahrain +
(24)
NA NA +
(24)
NA NA
Oman NA NA NA NA NA NA
U.A.E +
(17)
+
(17)
+
(17)
NA NA NA
Jordan NA NA NA NA NA NA
Turkey +
(27)
+
(27)
+
(27)
NA NA NA
Egypt NA NA NA NA NA NA
Iran +++
(20*^,28,29,30*^)
+
(20)
+
(20)
NA NA NA
Lebanon +++
(31*^)
NA NA NA NA NA
Morocco ++
(32)
NA NA NA NA NA

# NA: No Available Data
* Dermatophagoides pteronyssinus (Der p1)
^ Dermatophagoides farinae (Der f 1)



Special InstructionsLibrary of PDFs including pertinent information and forms related to the test

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