What is an allergy and how is allergy to pollen classified

AF069: Bet v 1 family

References

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  • Treatment: Drops of allergen taken orally
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    Castillon G, Salvo F, Moride Y.
    PubMed citation

  • Seutter von Loetzen C, Hoffmann T, Hartl MJ, Schweimer K, Schwab W, Rosch P, Hartl-Spiegelhauer O:
    Secret of the major birch pollen allergen Bet v 1: identification of the physiological ligand.
    Biochem J 2014, 457, 379-90. [PubMed][Full Text]
  • [The nocebo effect: Various aspects and consequences in clinical practice]
    Rev Med Interne. 2018 (39-5) 315-320
    Mouly S, Bergmann JF, Molimard M.
    PubMed citation

  • Anticholinergic drug use and cognitive performances in middle age: findings from the CONSTANCES cohort
    J Neurol Neurosurg Psychiatry.

    2018 (89-10) 1107-1115
    Ziad A, Olekhnovitch R, Ruiz F, Berr C, Bégaud B, Goldberg M, Zins M, Mura T.
    PubMed citation

  • Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators
    BMC Pharmacol Toxicol. 2018 (19-1) 27
    Opadeyi AO, Fourrier-Réglat A, Isah AO.
    PubMed citation

  • Sinus – Sinus pain, pressure, recurrent infection
  • Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample
    Drug Saf.

    2018 (41-11) 1049-1058
    Duong M, Abouelfath A, Lassalle R, Droz C, Blin P, Moore N.
    PubMed citation

  • Guhsl EE, Hofstetter G, Hemmer W, Ebner C, Vieths S, Vogel L, Breiteneder H, Radauer C:
    Vig r 6, the cytokinin-specific binding protein from mung bean (Vigna radiata) sprouts, cross-reacts with Bet v 1-related allergens and binds IgE from birch pollen allergic patients’ sera.
    Mol Nutr Food Res 2014, 58, 625-34. [PubMed][Full Text]
  • Systematic review of association between critical errors in inhalation and health outcomes in asthma and COPD
    NPJ Prim Care Respir Med.

    2018 (28-1) 43
    Kocks JWH, Chrystyn H, van der Palen J, Thomas M, Yates L, Landis SH, Driessen MT, Gokhale M, Sharma R, Molimard M.
    PubMed citation

  • Antipsychotics use: 2006-2013 trends in prevalence and incidence and characterization of users
    Eur J Clin Pharmacol. 2018 (74-5) 619-626
    Montastruc F, Bénard-Laribière A, Noize P, Pambrun E, Diaz-Bazin F, Tournier M, Bégaud B, Pariente A.
    PubMed citation

  • Treatment: Injections of allergen extract
  • Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database
    CNS Drugs.

    2018 (32-7) 673-684
    Billioti de Gage S, Collin C, Le-Tri T, Pariente A, Bégaud B, Verdoux H, Dray-Spira R, Zureik M.
    PubMed citation

  • Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
    Br J Clin Pharmacol. 2018 (84-8) 1764-1775
    Bénard-Laribière A, Pambrun E, Sutter-Dallay AL, Gautier S, Hurault-Delarue C, Damase-Michel C, Lacroix I, Bégaud B, Pariente A.
    PubMed citation

  • Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
    Eur Respir J.

    2018 (51) 1702523
    Humbert M, Taillé C, Mala L, Le Gros V, Just J, Molimard M.
    PubMed citation

  • A history of pharmacoepidemiology
    Therapie. 2018 (74-2) 175-179
    Bégaud B.
    PubMed citation

  • An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
    Allergy Asthma Clin Immunol. 2018 (14) 38
    Blin P, Demoly P, Drouet M, Falissard B, Lignot-Maleyran S, Maizi H, Lorrain S, Lassalle R, Droz-Perroteau C, Moore N, Molimard M.
    PubMed citation

  • Effectiveness and safety of 110 or 150 mg dabigatran versus vitamin K antagonists in non-valvular atrial fibrillation
    Br J Clin Pharmacol.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
    Br J Clin Pharmacol. 2018 (84-8) 1764-1775
    Bénard-Laribière A, Pambrun E, Sutter-Dallay AL, Gautier S, Hurault-Delarue C, Damase-Michel C, Lacroix I, Bégaud B, Pariente A.
    PubMed citation

  • Patterns of Use, Safety, and Effectiveness of Targeted Therapies in First-Line Treatment of Metastatic Colorectal Cancer According to Age: The STROMBOLI Cohort Study
    Clin Colorectal Cancer.

    2018 (18-1) e150-e162
    Gouverneur A, Coutureau J, Jové J, Rouyer M, Grelaud A, Duc S, Gérard S, Smith D, Ravaud A, Droz C, Bernard MA, Lassalle R, Forrier-Réglat A, Noize P; ETNA study group and the EREBUS study group.
    PubMed citation

  • Ears – Fluid in the middle ear, recurrent infections
  • Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases
    Lancet Psychiatry. 2018 (5-10) 824-835
    Raman SR, Man KKC, Bahmanyar S, Berard A, Bilder S, Boukhris T, Bushnell G, Crystal S, Furu K, KaoYang YH, Karlstad Ø, Kieler H, Kubota K, Lai EC, Martikainen JE, Maura G, Moore N, Montero D, Nakamura H, Neumann A, Pate V, Pottegård A, Pratt NL, Roughead EE, Macias Saint-Gerons D, Stürmer T, Su CC, Zoega H, Sturkenbroom MCJM, Chan EW, Coghill D, Ip P, Wong ICK.
    PubMed citation

  • [Will be 60 years the age of reason?]
    Presse Med.

    2018 (47-10) 870-871
    Bégaud B.
    PubMed citation

  • Rhabdomyolysis after co-istration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions
    Br J Clin Pharmacol. 2018 (84-5) 1057-1063
    Deljehier T, Pariente A, Miremont-Salamé G, Haramburu F, Nguyen L, Rubin S, Rigothier C, Théophile H.
    PubMed citation

  • Skin – Itching, welts, hives, blistery rash
  • Risk of Serious Trauma with Glucose-Lowering Drugs in Older Persons: A Nested Case-Control Study
    J Am Geriatr Soc.

    2018 (66-11) 2086-2091
    Arnaud M, Pariente A, Bezin J, Bégaud B, Salvo F.
    PubMed citation

  • Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after entire hip or knee replacement: a nationwide database cohort study
    Pharmacol Res. 2018 (141) 201-207
    Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, Lorrain S, Lassalle R, Droz-Perroteau C, Mismetti P, Moore N.
    PubMed citation

  • Lungs – Shortness of breath, wheezing, chest tightness, coughing
  • Pollen (Trees, Grasses, Weeds)
  • Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study
    Pharmacoepidemiol Drug Saf.

    2018 (27-11) 1174-1181
    Gulmez SE, Unal US, Lassalle R, Chartier A, Grolleau A, Moore N.
    PubMed citation

  • The economic burden of preventable adverse drug reactions: a systematic review of observational studies
    Expert Opin Drug Saf. 2018 (17-7) 681-695
    Formica D, Sultana J, Cutroneo PM, Lucchesi S, Angelica R, Crisafulli S, Ingrasciotta Y, Salvo F, Spina E, Trifirò G.
    PubMed citation

  • Authors’ Reply to Cohen et al.’s Comment on «Central Demyelinating Diseases after Vaccination Against Hepatitis B Virus: A Disproportionality Analysis within the VAERS Database»
    Drug Saf.

    2018 (41-12) 1429-1430
    Mouchet J, Bégaud B.
    PubMed citation

  • Reply to ‘The simple misuse of antidepressants during pregnancy is depressing’
    Br J Clin Pharmacol. 2018 (84-10) 2447-2448
    Bénard-Laribière A, Sutter-Dallay AL, Pariente A.
    PubMed citation

  • Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study
    Lancet Oncol. 2018 (19-12) 1579-1589
    Salem JE, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A, Gobert A, Spano JP, Balko JM, Bonaca MP, Roden DM, Johnson DB, Moslehi JJ.
    PubMed citation

  • Comparative effectiveness and safety of standard or reduced dose dabigatran versus rivaroxaban in non-valvular atrial fibrillation
    Clin Pharmacol Ther.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  • [Psychoactive substances use in Réunion Island and Mayotte, French departments in Indian Ocean]
    Therapie. 2018 (73-5) 419-427
    Daveluy A, Haramburu F.
    PubMed citation

  • Michalska K, Fernandes H, Sikorski M, Jaskolski M:
    Crystal structure of Hyp-1, a St. John’s wort protein implicated in the biosynthesis of hypericin.
    J Struct Biol 2010, 169, 161-71. [PubMed][Full Text]
  • Antipsychotics use: 2006-2013 trends in prevalence and incidence and characterization of users
    Eur J Clin Pharmacol.

    2018 (74-5) 619-626
    Montastruc F, Bénard-Laribière A, Noize P, Pambrun E, Diaz-Bazin F, Tournier M, Bégaud B, Pariente A.
    PubMed citation

  • Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: a retrospective database study in France
    Allergy. 2018 (ahead of print)
    Devillier P, Molimard M, Ansolabehere X, Bardoulat I, Coulombel N, Maurel F, Le Jeunne P, Demoly P.
    PubMed citation

  • Comparative effectiveness and safety of standard or reduced dose dabigatran versus rivaroxaban in non-valvular atrial fibrillation
    Clin Pharmacol Ther.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Inhaled triple therapy in chronic obstructive pulmonary disease
    Lancet. 2018 (392-10153) 1112
    Molimard M, Girodet PO, Moore N.
    PubMed citation

  • [Will be 60 years the age of reason?]
    Presse Med. 2018 (47-10) 870-871
    Bégaud B.
    PubMed citation

  • Payment: Covered by most insurance plans
  • [From psychoactive medicines to addictovigilance in French Public Health Code (1990-2017)]
    Therapie.

    2018 (ahead of print)
    Baumevieille M, Perri-Plandé J, Miremont-Salamé G, Daveluy A, Haramburu F.
    PubMed citation

  • Rhabdomyolysis after co-istration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions
    Br J Clin Pharmacol. 2018 (84-5) 1057-1063
    Deljehier T, Pariente A, Miremont-Salamé G, Haramburu F, Nguyen L, Rubin S, Rigothier C, Théophile H.
    PubMed citation

  • Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
    Eur Respir J.

    2018 (51) 1702523
    Humbert M, Taillé C, Mala L, Le Gros V, Just J, Molimard M.
    PubMed citation

  • [Should the duration of treatment be limited using benzodiazepines?]
    Presse Med. 2018 (47-10) 892-898
    Vorspan F, Barré T, Pariente A, Montastruc F, Tournier M.
    PubMed citation

  • Tamper-resistant prescription forms for narcotics in France: should we generalise them?
    Fundam Clin Pharmacol. 2018 (32-5) 571-577
    Daveluy A, Sauvaget L, Bastien A, Lapeyre-Mestre M, Collin C, Richard N, Haramburu F.
    PubMed citation

  • Hepatitis B vaccination and the putative risk of central demyelinating diseases — A systematic review and meta-analysis
    Vaccine.

    2018 (36-12) 1548-1555
    Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo IC, De Ponti F, Bégaud B.
    PubMed citation

  • Effectiveness of Cetuximab as First-Line Therapy for Patients With Wild-Type KRAS and Unresectable Metastatic Colorectal Cancer in Real-Life Practice: Results of the EREBUS Cohort
    Clin Colorectal Cancer. 2018 (17-2) 129-139
    Rouyer M, François E, Cunha AS, Monnereau A, Noize P, Robinson P, Droz-Perroteau C, Le Monies de Sagazan A, Jové J, Lassalle R, Moore N, Fourrier-Réglat A, Smith D; EREBUS Study Group.
    PubMed citation

  • Frequency: Weekly, for a 30-minute appointment
  • Markovic-Housley Z, Degano M, Lamba D, von Roepenack-Lahaye E, Clemens S, Susani M, Ferreira F, Scheiner O, Breiteneder H:
    Crystal structure of a hypoallergenic isoform of the major birch pollen allergen Bet v 1 and its likely biological function as a plant steroid carrier.
    J Mol Biol 2003, 325, 123-33.

    [PubMed]

  • [The nocebo effect: Various aspects and consequences in clinical practice]
    Rev Med Interne. 2018 (39-5) 315-320
    Mouly S, Bergmann JF, Molimard M.
    PubMed citation

  • Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis
    Drug Saf. 2018 (41-9) 881-897
    Maura G, Billionnet C, Coste J, Weill A, Neumann A, Pariente A.
    PubMed citation

  • Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System.
    Drug Saf.

    2018 (ahead of print)
    Moore N, Duret S, Grolleau A, Lassalle R, Barbet V, Duong M, Thurin N, Droz-Perroteau C, Gulmez SE.
    PubMed citation

  • Secondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database
    Atherosclerosis. 2018 (ahead of print)
    Blin P, Dureau-Pournin C, Benichou J, Bonello L, Dallongeville J, Danchin N, Falissard B, Thomas-Delecourt F, Jové J, Lassalle R, Droz C, Moore N.
    PubMed citation

  • [Understanding the distrust towards the assessment of medicines.

    Beyond conflict of interests]
    Therapie. 2018 (73-4) 341-348
    Tournay V, Pariente A.
    PubMed citation

  • Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis
    Pharmacol Res. 2018 (132) 108-118
    Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo IC, De Ponti F, Bégaud B.
    PubMed citation

  • Biomonitoring of occupational exposure to 5-FU by assaying ?-fluoro-?-alanine in urine with a highly sensitive UHPLC-MS/MS method
    Analyst.

    2018 (143-17) 4110-4117
    Dhersin A, Atgé B, Martinez B, Titier K, Rousset M, Sidatt Cheikh El Moustaph M, Verdun-Esquer C, Molimard M, Villa A, Canal-Raffin M.
    PubMed citation

  • Adverse drug reactions of analgesic medicines: analysis of the Romanian pharmacovigilance database
    Fundam Clin Pharmacol. 2018 (32-3) 330-336
    Cazacu I, Stroe R, Dondera R, Mogosan C, Haramburu F, Fourrier-Réglat A, Loghin F.
    PubMed citation

  • Sliwiak J, Dolot R, Michalska K, Szpotkowski K, Bujacz G, Sikorski M, Jaskolski M:
    Crystallographic and CD probing of ligand-induced conformational changes in a plant PR-10 protein.
    J Struct Biol 2016, 193, 55-66.

    [PubMed][Full Text]

  • istered: In your home
  • Risk of Serious Trauma with Glucose-Lowering Drugs in Older Persons: A Nested Case-Control Study
    J Am Geriatr Soc. 2018 (66-11) 2086-2091
    Arnaud M, Pariente A, Bezin J, Bégaud B, Salvo F.
    PubMed citation

  • istered: In your physician’s office
  • The economic burden of preventable adverse drug reactions: a systematic review of observational studies
    Expert Opin Drug Saf. 2018 (17-7) 681-695
    Formica D, Sultana J, Cutroneo PM, Lucchesi S, Angelica R, Crisafulli S, Ingrasciotta Y, Salvo F, Spina E, Trifirò G.
    PubMed citation

  • Vieths S, Scheurer S, Ballmer-Weber B:
    Current understanding of cross-reactivity of food allergens and pollen.
    Ann N Y Acad Sci 2002, 964, 47-68.

    [PubMed]

  • [Benzodiazepine use and misuse in France]
    Presse Med. 2018 (47-10) 878-881
    Bénard-Laribière A, Pariente A.
    PubMed citation

  • Adverse drug reactions of analgesic medicines: analysis of the Romanian pharmacovigilance database
    Fundam Clin Pharmacol. 2018 (32-3) 330-336
    Cazacu I, Stroe R, Dondera R, Mogosan C, Haramburu F, Fourrier-Réglat A, Loghin F.
    PubMed citation

  • You may use fewer medications.

[top]

Common Symptoms of Allergies

  1. Ears – Fluid in the middle ear, recurrent infections
  2. Sinus – Sinus pain, pressure, recurrent infection
  3. Lungs – Shortness of breath, wheezing, chest tightness, coughing
  4. Eyes – Itching, redness, swelling, tearing
  5. Nose – Itching, congestion, sneezing, postnasal drip
  6. Skin – Itching, welts, hives, blistery rash
  7. Other – Headaches, fatigue, hyperactivity, depression

Common Causes of Allergies

  1. Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database
    CNS Drugs.

    2018 (32-7) 673-684
    Billioti de Gage S, Collin C, Le-Tri T, Pariente A, Bégaud B, Verdoux H, Dray-Spira R, Zureik M.
    PubMed citation

  2. The economic burden of preventable adverse drug reactions: a systematic review of observational studies
    Expert Opin Drug Saf. 2018 (17-7) 681-695
    Formica D, Sultana J, Cutroneo PM, Lucchesi S, Angelica R, Crisafulli S, Ingrasciotta Y, Salvo F, Spina E, Trifirò G.
    PubMed citation

  3. Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study
    Pharmacoepidemiol Drug Saf.

    2018 (27-11) 1174-1181
    Gulmez SE, Unal US, Lassalle R, Chartier A, Grolleau A, Moore N.
    PubMed citation

  4. [From psychoactive medicines to addictovigilance in French Public Health Code (1990-2017)]
    Therapie. 2018 (ahead of print)
    Baumevieille M, Perri-Plandé J, Miremont-Salamé G, Daveluy A, Haramburu F.
    PubMed citation

  5. Antibiotics associated with acquisition of carbapenem-resistant Pseudomonas aeruginosa in ICUs: a multicentre nested case-case-control study
    J Antimicrob Chemother.

    2018 (ahead of print)
    Coppry M, Jeanne-Leroyer C, Noize P, Dumartin C, Boyer A, Bertrand X, Dubois V, Rogues AM.
    PubMed citation

  6. Risk of Serious Trauma with Glucose-Lowering Drugs in Older Persons: A Nested Case-Control Study
    J Am Geriatr Soc. 2018 (66-11) 2086-2091
    Arnaud M, Pariente A, Bezin J, Bégaud B, Salvo F.
    PubMed citation

  7. [Use and misuse of benzodiazepines out of France]
    Presse Med. 2018 (47-10) 882-885
    Tournier M, Pariente A, Bégaud B, Bénard-Laribière A.
    PubMed citation

  8. Propensity Score-Based Approaches in High Dimension for Pharmacovigilance Signal Detection: an Empirical Comparison on the French Spontaneous Reporting Database
    Front Pharmacol.

    2018 (9) 1010
    Courtois É, Pariente A, Salvo F, Volatier É, Tubert-Bitter P, Ahmed I.
    PubMed citation

  9. Biomonitoring of occupational exposure to 5-FU by assaying ?-fluoro-?-alanine in urine with a highly sensitive UHPLC-MS/MS method
    Analyst. 2018 (143-17) 4110-4117
    Dhersin A, Atgé B, Martinez B, Titier K, Rousset M, Sidatt Cheikh El Moustaph M, Verdun-Esquer C, Molimard M, Villa A, Canal-Raffin M.
    PubMed citation

  10. Systematic review of association between critical errors in inhalation and health outcomes in asthma and COPD
    NPJ Prim Care Respir Med.

    2018 (28-1) 43
    Kocks JWH, Chrystyn H, van der Palen J, Thomas M, Yates L, Landis SH, Driessen MT, Gokhale M, Sharma R, Molimard M.
    PubMed citation

  11. Baseline results from the European non-interventional Antipsychotic Endless acTing injection in schizOphrenia (ALTO) study
    Eur Psychiatry. 2018 (52) 85-94
    Llorca PM, Bobes J, Fleischhacker WW, Heres S, Moore N, Bent-Ennakhil N, Sapin C, Loze JY, Nylander AG, Patel MX.
    PubMed citation

  12. Non-communicable diseases in Indian slums: re-framing the Social Determinants of Health
    Glob Health Action.

    2018 (11-1)
    Lumagbas LB, Coleman HLS, Bunders J, Pariente A, Belonje A, de Cock Buning T.
    PubMed citation

  13. Hepatitis B vaccination and the putative risk of central demyelinating diseases — A systematic review and meta-analysis
    Vaccine. 2018 (36-12) 1548-1555
    Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo IC, De Ponti F, Bégaud B.
    PubMed citation

  14. Interest of pharmacoepidemiology for the study of inhaled drugs
    Therapie.

    2018 (ahead of print)
    Molimard M, Girodet PO, Van Ganse E.
    PubMed citation

  15. [Should the duration of treatment be limited using benzodiazepines?]
    Presse Med. 2018 (47-10) 892-898
    Vorspan F, Barré T, Pariente A, Montastruc F, Tournier M.
    PubMed citation

  16. Tamper-resistant prescription forms for narcotics in France: should we generalise them?
    Fundam Clin Pharmacol. 2018 (32-5) 571-577
    Daveluy A, Sauvaget L, Bastien A, Lapeyre-Mestre M, Collin C, Richard N, Haramburu F.
    PubMed citation

  17. Use of lipid-lowering drugs and the risk of cataract: a population-based nested case-control study
    Clin Pharmacol Ther.

    2018 (105-2) 458-465
    Bezin J, Mansiaux Y, Noize P, Salvo F, Bégaud B, Pariente A.
    PubMed citation

  18. Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study
    Eur Arch Psychiatry Clin Neurosci. 2018 (ahead of print)
    Panes A, Pariente A, Bénard-Laribière A, Lassalle R, Dureau-Pournin C, Lorrain S, Tournier M, Fourrier-Réglat A.
    PubMed citation

  19. Pharmacoepidemiology of non-steroidal anti-inflammatory drugs
    Therapie. 2018 (74-2) 271-277
    Moore N, Duong M, Gulmez SE, Blin P, Droz C.
    PubMed citation

  20. Atropinic (Anticholinergic) Burden in Antipsychotic-Treated Patients
    Fundam Clin Pharmacol.

    2018 (32-1) 114-119
    Montastruc F, Benevent J, Touafchia A, Chebane L, Araujo M, Guitton-Bondon E, Durrieu G, Arbus C, Schmitt L, Bé gaud B, Montastruc JL.
    PubMed citation

  21. Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample
    Drug Saf. 2018 (41-11) 1049-1058
    Duong M, Abouelfath A, Lassalle R, Droz C, Blin P, Moore N.
    PubMed citation

  22. Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: a retrospective database study in France
    Allergy.

    2018 (ahead of print)
    Devillier P, Molimard M, Ansolabehere X, Bardoulat I, Coulombel N, Maurel F, Le Jeunne P, Demoly P.
    PubMed citation

  23. children: A pilot study
    Environ Res. 2018 (169) 189-195
    Raherison C, Baldi I, Pouquet M, Berteaud E, Moesch C, Bouvier G, Canal-Raffin M.
    PubMed citation

  24. Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis
    Pharmacol Res.

    2018 (132) 108-118
    Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo IC, De Ponti F, Bégaud B.
    PubMed citation

  25. Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after entire hip or knee replacement: a nationwide database cohort study
    Pharmacol Res. 2018 (141) 201-207
    Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, Lorrain S, Lassalle R, Droz-Perroteau C, Mismetti P, Moore N.
    PubMed citation

  26. Inclusion of elderly or frail patients in randomized controlled trials of targeted therapies for the treatment of metastatic colorectal cancer: A systematic review
    J Geriatr Oncol.

    2018 (9-1) 15-23
    Gouverneur A, Salvo F, Berdaï D, Moore N, Fourrier-Réglat A, Noize P.
    PubMed citation

  27. Pharmacovigilance of sodium-glucose co-transporter-2 inhibitors: What a clinician should know on disproportionality analysis of spontaneous reporting systems
    Nutr Metab Cardiovasc Dis. 2018 (28-6) 533-542
    Raschi E, Poluzzi E, Salvo F, Pariente A, De Ponti F, Marchesini G, Moretti U.
    PubMed citation

  28. Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
    Eur Respir J. 2018 (51) 1702523
    Humbert M, Taillé C, Mala L, Le Gros V, Just J, Molimard M.
    PubMed citation

  29. Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators
    BMC Pharmacol Toxicol.

    2018 (19-1) 27
    Opadeyi AO, Fourrier-Réglat A, Isah AO.
    PubMed citation

  30. Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
    Br J Clin Pharmacol. 2018 (84-8) 1764-1775
    Bénard-Laribière A, Pambrun E, Sutter-Dallay AL, Gautier S, Hurault-Delarue C, Damase-Michel C, Lacroix I, Bégaud B, Pariente A.
    PubMed citation

  31. Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System.
    Drug Saf.

    2018 (ahead of print)
    Moore N, Duret S, Grolleau A, Lassalle R, Barbet V, Duong M, Thurin N, Droz-Perroteau C, Gulmez SE.
    PubMed citation

  32. Food
  33. Secondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database
    Atherosclerosis. 2018 (ahead of print)
    Blin P, Dureau-Pournin C, Benichou J, Bonello L, Dallongeville J, Danchin N, Falissard B, Thomas-Delecourt F, Jové J, Lassalle R, Droz C, Moore N.
    PubMed citation

  34. Detection of drug safety signals from clinical trials data: Role of SUSARs
    Pharmacol Res.

    2018 (131) 218-223
    Perez C, Olivier P, Lortal B, Duranton S, Montastruc JL, Colin AL, Toulza E, Becker M, Hamy L, Crepin S, Roussillon C, Gimbert A, Petitpain N, Salvo F.
    PubMed citation

  35. Authors’ Reply to Cohen et al.’s Comment on «Central Demyelinating Diseases after Vaccination Against Hepatitis B Virus: A Disproportionality Analysis within the VAERS Database»
    Drug Saf. 2018 (41-12) 1429-1430
    Mouchet J, Bégaud B.
    PubMed citation

  36. [Understanding the distrust towards the assessment of medicines.

    Beyond conflict of interests]
    Therapie. 2018 (73-4) 341-348
    Tournay V, Pariente A.
    PubMed citation

  37. Inhaled triple therapy in chronic obstructive pulmonary disease
    Lancet. 2018 (392-10153) 1112
    Molimard M, Girodet PO, Moore N.
    PubMed citation

  38. The Social Impact of Suspected Adverse Drug Reactions: An analysis of the Canada Vigilance Spontaneous Reporting Database
    Drug Saf.

    2018 (42-1) 27-34
    Castillon G, Salvo F, Moride Y.
    PubMed citation

  39. [Benzodiazepine use and misuse in France]
    Presse Med. 2018 (47-10) 878-881
    Bénard-Laribière A, Pariente A.
    PubMed citation

  40. Central Demyelinating Diseases after Vaccination Against Hepatitis B Virus: A Disproportionality Analysis within the VAERS Database
    Drug Saf.

    2018 (41-8) 767-774
    Mouchet J, Bégaud B.
    PubMed citation

  41. Interest and challenges of pharmacoepidemiology for the study of drugs used in diabetes
    Therapie. 2018 (74-2) 255-260
    Salvo F, Faillie JL.
    PubMed citation

  42. Antipsychotics use: 2006-2013 trends in prevalence and incidence and characterization of users
    Eur J Clin Pharmacol. 2018 (74-5) 619-626
    Montastruc F, Bénard-Laribière A, Noize P, Pambrun E, Diaz-Bazin F, Tournier M, Bégaud B, Pariente A.
    PubMed citation

  43. High throughput routine determination of 17 tyrosine kinase inhibitors by LC-MS/MS
    J Pharm Biomed Anal.

    2018 (150) 112-120
    Merienne C, Rousset M, Ducint D, Castaing N, Titier K, Molimard M, Bouchet S.
    PubMed citation

  44. Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis
    Oncotarget. 2018 (9-42) 26724-26736
    Calmettes C, Gabriel F, Blanchard E, Servant V, Bouchet S, Kabore N, Forcade E, Leroyer C, Bidet A, Latrabe V, Leguay T, Vigouroux S, Tabrizi R, Breilh D, Accoceberry I, de Lara MT, Pigneux A, Milpied N, Dumas PY.
    PubMed citation

  45. Comparative effectiveness and safety of standard or reduced dose dabigatran versus rivaroxaban in non-valvular atrial fibrillation
    Clin Pharmacol Ther.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  46. [Psychoactive substances use in Réunion Island and Mayotte, French departments in Indian Ocean]
    Therapie. 2018 (73-5) 419-427
    Daveluy A, Haramburu F.
    PubMed citation

  47. [The nocebo effect: Various aspects and consequences in clinical practice]
    Rev Med Interne.

    2018 (39-5) 315-320
    Mouly S, Bergmann JF, Molimard M.
    PubMed citation

  48. Dust Mites
  49. Diagnostic accuracy of the International Classification of Diseases, Tenth Revision, codes of heart failure in an istrative database
    Pharmacoepidemiol Drug Saf. 2018 (ahead of print)
    Bosco-Lévy P, Duret S, Picard F, Dos Santos P, Puymirat E, Gilleron V, Blin P, Chatellier G, Looten V, Moore N.
    PubMed citation

  50. Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics
    Postgrad Med. 2018 (130-2) 188-199
    Moore N, Scheiman JM.
    PubMed citation

  51. Increased endless QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors
    Heart.

    2018 (104-22) 1859-1863
    Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE.
    PubMed citation

  52. Adverse drug reactions of analgesic medicines: analysis of the Romanian pharmacovigilance database
    Fundam Clin Pharmacol. 2018 (32-3) 330-336
    Cazacu I, Stroe R, Dondera R, Mogosan C, Haramburu F, Fourrier-Réglat A, Loghin F.
    PubMed citation

  53. A history of pharmacoepidemiology
    Therapie. 2018 (74-2) 175-179
    Bégaud B.
    PubMed citation

  54. [Use and misuse of benzodiazepines in patients with psychiatric disorders]
    Presse Med.

    2018 (47-10) 886-891
    Panes A, Fourrier-Réglat A, Verdoux H, Tournier M.
    PubMed citation

  55. Pollen (Trees, Grasses, Weeds)
  56. Comorbidities and COPD severity in a clinic-based cohort
    BMC Pulm Med. 2018 (18-1) 117
    Raherison C, Ouaalaya EH, Bernady A, Casteigt J, Nocent-Eijnani C, Falque L, Le Guillou F, Nguyen L, Ozier A, Molimard M.
    PubMed citation

  57. Patterns of Use, Safety, and Effectiveness of Targeted Therapies in First-Line Treatment of Metastatic Colorectal Cancer According to Age: The STROMBOLI Cohort Study
    Clin Colorectal Cancer.

    2018 (18-1) e150-e162
    Gouverneur A, Coutureau J, Jové J, Rouyer M, Grelaud A, Duc S, Gérard S, Smith D, Ravaud A, Droz C, Bernard MA, Lassalle R, Forrier-Réglat A, Noize P; ETNA study group and the EREBUS study group.
    PubMed citation

  58. Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis
    Drug Saf. 2018 (41-9) 881-897
    Maura G, Billionnet C, Coste J, Weill A, Neumann A, Pariente A.
    PubMed citation

  59. Impact of cancer diagnosis on persistence of oral antidiabetic drugs
    Diabetes Res Clin Pract.

    2018 (139) 323-330
    Létinier L, Mansiaux Y, Pariente A, Fourrier-Réglat A.
    PubMed citation

  60. Effectiveness of Cetuximab as First-Line Therapy for Patients With Wild-Type KRAS and Unresectable Metastatic Colorectal Cancer in Real-Life Practice: Results of the EREBUS Cohort
    Clin Colorectal Cancer. 2018 (17-2) 129-139
    Rouyer M, François E, Cunha AS, Monnereau A, Noize P, Robinson P, Droz-Perroteau C, Le Monies de Sagazan A, Jové J, Lassalle R, Moore N, Fourrier-Réglat A, Smith D; EREBUS Study Group.
    PubMed citation

  61. Insect Stings/Bites
  62. Reply to ‘The simple misuse of antidepressants during pregnancy is depressing’
    Br J Clin Pharmacol.

    2018 (84-10) 2447-2448
    Bénard-Laribière A, Sutter-Dallay AL, Pariente A.
    PubMed citation

  63. Effectiveness and safety of 110 or 150 mg dabigatran versus vitamin K antagonists in non-valvular atrial fibrillation
    Br J Clin Pharmacol. 2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  64. Mold
  65. Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases
    Lancet Psychiatry.

    2018 (5-10) 824-835
    Raman SR, Man KKC, Bahmanyar S, Berard A, Bilder S, Boukhris T, Bushnell G, Crystal S, Furu K, KaoYang YH, Karlstad Ø, Kieler H, Kubota K, Lai EC, Martikainen JE, Maura G, Moore N, Montero D, Nakamura H, Neumann A, Pate V, Pottegård A, Pratt NL, Roughead EE, Macias Saint-Gerons D, Stürmer T, Su CC, Zoega H, Sturkenbroom MCJM, Chan EW, Coghill D, Ip P, Wong ICK.
    PubMed citation

  66. An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
    Allergy Asthma Clin Immunol.

    2018 (14) 38
    Blin P, Demoly P, Drouet M, Falissard B, Lignot-Maleyran S, Maizi H, Lorrain S, Lassalle R, Droz-Perroteau C, Moore N, Molimard M.
    PubMed citation

  67. [Will be 60 years the age of reason?]
    Presse Med. 2018 (47-10) 870-871
    Bégaud B.
    PubMed citation

  68. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study
    Lancet Oncol.

    2018 (19-12) 1579-1589
    Salem JE, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A, Gobert A, Spano JP, Balko JM, Bonaca MP, Roden DM, Johnson DB, Moslehi JJ.
    PubMed citation

  69. Antidepressants during pregnancy: a French drug utilisation study in EFEMERIS cohort
    Eur Arch Psychiatry Clin Neurosci. 2018 (ahead of print)
    Hurault-Delarue C, Lacroix I, Bénard-Laribière A, Montastruc JL, Pariente A, Damase-Michel C.
    PubMed citation

  70. Animal Hair/Dander
  71. Rhabdomyolysis after co-istration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions
    Br J Clin Pharmacol.

    2018 (84-5) 1057-1063
    Deljehier T, Pariente A, Miremont-Salamé G, Haramburu F, Nguyen L, Rubin S, Rigothier C, Théophile H.
    PubMed citation

  72. Monitoring of drug misuse or potential misuse in a nationwide healthcare insurance database: A cross-sectional study in France
    Therapie. 2018 (ahead of print)
    Bénard-Laribière A, Noize P, Girodet PO, Lassalle R, Dureau-Pournin C, Droz-Perroteau C, Fourrier-Réglat A, Salvo F, Bezin J, Pariente A; DRUGS-2M study group.
    PubMed citation

  73. Anticholinergic drug use and cognitive performances in middle age: findings from the CONSTANCES cohort
    J Neurol Neurosurg Psychiatry.

    2018 (89-10) 1107-1115
    Ziad A, Olekhnovitch R, Ruiz F, Berr C, Bégaud B, Goldberg M, Zins M, Mura T.
    PubMed citation

Did you know? 60 million people in the U.S. suffer from allergies. That’s enough people to classify as an allergy epidemic!

Biochemical properties

Bet v 1-related proteins are widely distributed among vascular plants. The family was classified by sequence similarity into two large and several little subfamilies showing low levels of sequence identity but conserved structures [1]. The largest of these is the pathogenesis-related protein family PR-10 [2]. The expression of these proteins is either induced by pathogen attack or abiotic stress or developmentally regulated.

PR-10 proteins are expressed in high concentrations in reproductive tissues such as pollen, seeds and fruits. The biochemical function of most PR-10 proteins is unknown. For some PR-10 subfamily members an enzymatic function as ribonuclease [3] or oxidative coupling enzyme involved in biosynthesis of secondary metabolites was shown [4]. Love every members of the Bet v 1-family, PR-10 proteins contain a large ligand-binding cavity that can accommodate diverse ligands including plant steroids [5], cytokinins [6] and flavonoids [7]. The other large subfamily is a group of major latex proteins and ripening-related proteins (MLP/RRP) first described in the latex of opium poppy [8].

Their biologic function is unknown, but they appear to own a role in defense against biotic and abiotic stress [9].

Links to Wikipedia

[top]

If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

  • Risk of Serious Trauma with Glucose-Lowering Drugs in Older Persons: A Nested Case-Control Study
    J Am Geriatr Soc. 2018 (66-11) 2086-2091
    Arnaud M, Pariente A, Bezin J, Bégaud B, Salvo F.
    PubMed citation

  • [From psychoactive medicines to addictovigilance in French Public Health Code (1990-2017)]
    Therapie.

    2018 (ahead of print)
    Baumevieille M, Perri-Plandé J, Miremont-Salamé G, Daveluy A, Haramburu F.
    PubMed citation

  • [Will be 60 years the age of reason?]
    Presse Med. 2018 (47-10) 870-871
    Bégaud B.
    PubMed citation

  • A history of pharmacoepidemiology
    Therapie. 2018 (74-2) 175-179
    Bégaud B.
    PubMed citation

  • Monitoring of drug misuse or potential misuse in a nationwide healthcare insurance database: A cross-sectional study in France
    Therapie.

    2018 (ahead of print)
    Bénard-Laribière A, Noize P, Girodet PO, Lassalle R, Dureau-Pournin C, Droz-Perroteau C, Fourrier-Réglat A, Salvo F, Bezin J, Pariente A; DRUGS-2M study group.
    PubMed citation

  • Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
    Br J Clin Pharmacol. 2018 (84-8) 1764-1775
    Bénard-Laribière A, Pambrun E, Sutter-Dallay AL, Gautier S, Hurault-Delarue C, Damase-Michel C, Lacroix I, Bégaud B, Pariente A.
    PubMed citation

  • [Benzodiazepine use and misuse in France]
    Presse Med.

    2018 (47-10) 878-881
    Bénard-Laribière A, Pariente A.
    PubMed citation

  • Reply to ‘The simple misuse of antidepressants during pregnancy is depressing’
    Br J Clin Pharmacol. 2018 (84-10) 2447-2448
    Bénard-Laribière A, Sutter-Dallay AL, Pariente A.
    PubMed citation

  • Use of lipid-lowering drugs and the risk of cataract: a population-based nested case-control study
    Clin Pharmacol Ther. 2018 (105-2) 458-465
    Bezin J, Mansiaux Y, Noize P, Salvo F, Bégaud B, Pariente A.
    PubMed citation

  • Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database
    CNS Drugs.

    2018 (32-7) 673-684
    Billioti de Gage S, Collin C, Le-Tri T, Pariente A, Bégaud B, Verdoux H, Dray-Spira R, Zureik M.
    PubMed citation

  • An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
    Allergy Asthma Clin Immunol. 2018 (14) 38
    Blin P, Demoly P, Drouet M, Falissard B, Lignot-Maleyran S, Maizi H, Lorrain S, Lassalle R, Droz-Perroteau C, Moore N, Molimard M.
    PubMed citation

  • Secondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database
    Atherosclerosis.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Benichou J, Bonello L, Dallongeville J, Danchin N, Falissard B, Thomas-Delecourt F, Jové J, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Effectiveness and safety of 110 or 150 mg dabigatran versus vitamin K antagonists in non-valvular atrial fibrillation
    Br J Clin Pharmacol. 2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Comparative effectiveness and safety of standard or reduced dose dabigatran versus rivaroxaban in non-valvular atrial fibrillation
    Clin Pharmacol Ther.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after entire hip or knee replacement: a nationwide database cohort study
    Pharmacol Res.

    What is an allergy and how is allergy to pollen classified

    2018 (141) 201-207
    Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, Lorrain S, Lassalle R, Droz-Perroteau C, Mismetti P, Moore N.
    PubMed citation

  • Diagnostic accuracy of the International Classification of Diseases, Tenth Revision, codes of heart failure in an istrative database
    Pharmacoepidemiol Drug Saf. 2018 (ahead of print)
    Bosco-Lévy P, Duret S, Picard F, Dos Santos P, Puymirat E, Gilleron V, Blin P, Chatellier G, Looten V, Moore N.
    PubMed citation

  • Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis
    Oncotarget.

    2018 (9-42) 26724-26736
    Calmettes C, Gabriel F, Blanchard E, Servant V, Bouchet S, Kabore N, Forcade E, Leroyer C, Bidet A, Latrabe V, Leguay T, Vigouroux S, Tabrizi R, Breilh D, Accoceberry I, de Lara MT, Pigneux A, Milpied N, Dumas PY.
    PubMed citation

  • The Social Impact of Suspected Adverse Drug Reactions: An analysis of the Canada Vigilance Spontaneous Reporting Database
    Drug Saf. 2018 (42-1) 27-34
    Castillon G, Salvo F, Moride Y.
    PubMed citation

  • Adverse drug reactions of analgesic medicines: analysis of the Romanian pharmacovigilance database
    Fundam Clin Pharmacol.

    2018 (32-3) 330-336
    Cazacu I, Stroe R, Dondera R, Mogosan C, Haramburu F, Fourrier-Réglat A, Loghin F.
    PubMed citation

  • Antibiotics associated with acquisition of carbapenem-resistant Pseudomonas aeruginosa in ICUs: a multicentre nested case-case-control study
    J Antimicrob Chemother. 2018 (ahead of print)
    Coppry M, Jeanne-Leroyer C, Noize P, Dumartin C, Boyer A, Bertrand X, Dubois V, Rogues AM.
    PubMed citation

  • Propensity Score-Based Approaches in High Dimension for Pharmacovigilance Signal Detection: an Empirical Comparison on the French Spontaneous Reporting Database
    Front Pharmacol.

    2018 (9) 1010
    Courtois É, Pariente A, Salvo F, Volatier É, Tubert-Bitter P, Ahmed I.
    PubMed citation

  • [Psychoactive substances use in Réunion Island and Mayotte, French departments in Indian Ocean]
    Therapie. 2018 (73-5) 419-427
    Daveluy A, Haramburu F.
    PubMed citation

  • Tamper-resistant prescription forms for narcotics in France: should we generalise them?
    Fundam Clin Pharmacol. 2018 (32-5) 571-577
    Daveluy A, Sauvaget L, Bastien A, Lapeyre-Mestre M, Collin C, Richard N, Haramburu F.
    PubMed citation

  • Rhabdomyolysis after co-istration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions
    Br J Clin Pharmacol.

    2018 (84-5) 1057-1063
    Deljehier T, Pariente A, Miremont-Salamé G, Haramburu F, Nguyen L, Rubin S, Rigothier C, Théophile H.
    PubMed citation

  • Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: a retrospective database study in France
    Allergy. 2018 (ahead of print)
    Devillier P, Molimard M, Ansolabehere X, Bardoulat I, Coulombel N, Maurel F, Le Jeunne P, Demoly P.
    PubMed citation

  • Biomonitoring of occupational exposure to 5-FU by assaying ?-fluoro-?-alanine in urine with a highly sensitive UHPLC-MS/MS method
    Analyst.

    2018 (143-17) 4110-4117
    Dhersin A, Atgé B, Martinez B, Titier K, Rousset M, Sidatt Cheikh El Moustaph M, Verdun-Esquer C, Molimard M, Villa A, Canal-Raffin M.
    PubMed citation

  • Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample
    Drug Saf. 2018 (41-11) 1049-1058
    Duong M, Abouelfath A, Lassalle R, Droz C, Blin P, Moore N.
    PubMed citation

  • The economic burden of preventable adverse drug reactions: a systematic review of observational studies
    Expert Opin Drug Saf.

    2018 (17-7) 681-695
    Formica D, Sultana J, Cutroneo PM, Lucchesi S, Angelica R, Crisafulli S, Ingrasciotta Y, Salvo F, Spina E, Trifirò G.
    PubMed citation

  • Patterns of Use, Safety, and Effectiveness of Targeted Therapies in First-Line Treatment of Metastatic Colorectal Cancer According to Age: The STROMBOLI Cohort Study
    Clin Colorectal Cancer. 2018 (18-1) e150-e162
    Gouverneur A, Coutureau J, Jové J, Rouyer M, Grelaud A, Duc S, Gérard S, Smith D, Ravaud A, Droz C, Bernard MA, Lassalle R, Forrier-Réglat A, Noize P; ETNA study group and the EREBUS study group.
    PubMed citation

  • Inclusion of elderly or frail patients in randomized controlled trials of targeted therapies for the treatment of metastatic colorectal cancer: A systematic review
    J Geriatr Oncol.

    2018 (9-1) 15-23
    Gouverneur A, Salvo F, Berdaï D, Moore N, Fourrier-Réglat A, Noize P.
    PubMed citation

  • Increased endless QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors
    Heart. 2018 (104-22) 1859-1863
    Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE.
    PubMed citation

  • Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study
    Pharmacoepidemiol Drug Saf.

    2018 (27-11) 1174-1181
    Gulmez SE, Unal US, Lassalle R, Chartier A, Grolleau A, Moore N.
    PubMed citation

  • Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
    Eur Respir J. 2018 (51) 1702523
    Humbert M, Taillé C, Mala L, Le Gros V, Just J, Molimard M.
    PubMed citation

  • Antidepressants during pregnancy: a French drug utilisation study in EFEMERIS cohort
    Eur Arch Psychiatry Clin Neurosci. 2018 (ahead of print)
    Hurault-Delarue C, Lacroix I, Bénard-Laribière A, Montastruc JL, Pariente A, Damase-Michel C.
    PubMed citation

  • Systematic review of association between critical errors in inhalation and health outcomes in asthma and COPD
    NPJ Prim Care Respir Med.

    2018 (28-1) 43
    Kocks JWH, Chrystyn H, van der Palen J, Thomas M, Yates L, Landis SH, Driessen MT, Gokhale M, Sharma R, Molimard M.
    PubMed citation

  • Impact of cancer diagnosis on persistence of oral antidiabetic drugs
    Diabetes Res Clin Pract. 2018 (139) 323-330
    Létinier L, Mansiaux Y, Pariente A, Fourrier-Réglat A.
    PubMed citation

  • Baseline results from the European non-interventional Antipsychotic Endless acTing injection in schizOphrenia (ALTO) study
    Eur Psychiatry. 2018 (52) 85-94
    Llorca PM, Bobes J, Fleischhacker WW, Heres S, Moore N, Bent-Ennakhil N, Sapin C, Loze JY, Nylander AG, Patel MX.
    PubMed citation

  • Non-communicable diseases in Indian slums: re-framing the Social Determinants of Health
    Glob Health Action.

    2018 (11-1)
    Lumagbas LB, Coleman HLS, Bunders J, Pariente A, Belonje A, de Cock Buning T.
    PubMed citation

  • Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis
    Drug Saf. 2018 (41-9) 881-897
    Maura G, Billionnet C, Coste J, Weill A, Neumann A, Pariente A.
    PubMed citation

  • High throughput routine determination of 17 tyrosine kinase inhibitors by LC-MS/MS
    J Pharm Biomed Anal.

    2018 (150) 112-120
    Merienne C, Rousset M, Ducint D, Castaing N, Titier K, Molimard M, Bouchet S.
    PubMed citation

  • Inhaled triple therapy in chronic obstructive pulmonary disease
    Lancet. 2018 (392-10153) 1112
    Molimard M, Girodet PO, Moore N.
    PubMed citation

  • Interest of pharmacoepidemiology for the study of inhaled drugs
    Therapie. 2018 (ahead of print)
    Molimard M, Girodet PO, Van Ganse E.
    PubMed citation

  • Antipsychotics use: 2006-2013 trends in prevalence and incidence and characterization of users
    Eur J Clin Pharmacol.

    2018 (74-5) 619-626
    Montastruc F, Bénard-Laribière A, Noize P, Pambrun E, Diaz-Bazin F, Tournier M, Bégaud B, Pariente A.
    PubMed citation

  • Atropinic (Anticholinergic) Burden in Antipsychotic-Treated Patients
    Fundam Clin Pharmacol. 2018 (32-1) 114-119
    Montastruc F, Benevent J, Touafchia A, Chebane L, Araujo M, Guitton-Bondon E, Durrieu G, Arbus C, Schmitt L, Bé gaud B, Montastruc JL.
    PubMed citation

  • Pharmacoepidemiology of non-steroidal anti-inflammatory drugs
    Therapie.

    2018 (74-2) 271-277
    Moore N, Duong M, Gulmez SE, Blin P, Droz C.
    PubMed citation

  • Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System.
    Drug Saf. 2018 (ahead of print)
    Moore N, Duret S, Grolleau A, Lassalle R, Barbet V, Duong M, Thurin N, Droz-Perroteau C, Gulmez SE.
    PubMed citation

  • Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics
    Postgrad Med. 2018 (130-2) 188-199
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    13. Bousquet J, Malva J, Nogues M, Manas LR, Vellas B, Farrell J, Grp MR. Operational Definition of Athletic and Healthy Aging (AHA): The European Innovation Partnership (EIP) on AHA Reference Site Questionnaire: Montpellier October 20-21, 2014, Lisbon July 2, 2015. Journal of the American Medical Directors Association 2015; 16: 1020-1026.

    14.

    Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, Valiulis A, Wickman M, Zuberbier T, Bosnic-Anticevitch S, Bedbrook A, Bergmann KC, Caimmi D, Dahl R, Fokkens WJ, Grisle I, Lodrup Carlsen K, Mullol J, Muraro A, Palkonen S, Papadopoulos N, Passalacqua G, Ryan D, Valovirta E, Yorgancioglu A, Aberer W, Agache I, Adachi M, Akdis CA, Akdis M, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Baiardini I, Baigenzhin AK, Barbara C, Bateman ED, Beghe B, Bel EH, Ben Kheder A, Bennoor KS, Benson M, Bewick M, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Boner AL, Boulet LP, Bonini M, Bonini S, Bosse I, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Calderon MA, Camargos PAM, Camuzat T, Carlsen KH, Carr W, Sarabia AMC, Chavannes NH, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Ciprandi G, Cirule I, Correia de Sousa J, Cox L, Crooks G, Costa DJ, Custovic A, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Wagner AF, Fletcher M, Fiocchi A, Forastiere F, Gamkrelidze A, Gemicioglu B, Gereda JE, Gonzalez Diaz S, Gotua M, Grouse L, Guzman MA, Haahtela T, Hellquist-Dahl B, Heinrich J, Horak F, Hourihane Occupation, Howarth P, Humbert M, Hyland ME, Ivancevich JC, Jares EJ, Johnston SL, Joos G, Jonquet O, Jung KS, Just J, Kaidashev I, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Khaltaev N, Klimek L, N’Goran BK, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LTT, Lieberman P, Lipworth B, Li J, Louis R, Magard Y, Magnan A, Mahboub B, Majer I, Makela MJ, Manning P, De Manuel Keenoy E, Marshall GD, Masjedi MR, Maurer M, Mavale-Manuel S, Melen E, Melo-Gomes E, Meltzer EO, Merk H, Miculinic N, Mihaltan F, Milenkovic B, Mohammad Y, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Moesges R, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Nyembue TD, O’Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schoell I, Palmer S, Panzner P, Papi A, Park HS, Pavord I, Pawankar R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Pohl W, Popov TA, Portejoie F, Postma D, Potter P, Price D, Rabe KF, Raciborski F, Pontal FR, Repka-Ramirez S, Robalo-Cordeiro C, Rolland C, Rosado-Pinto J, Reitamo S, Rodenas F, Roman Rodriguez M, Romano A, Rosario N, Rosenwasser L, Rottem M, Sanchez-Borges M, Scadding GK, Serrano E, Schmid-Grendelmeier P, Sheikh A, Simons FER, Sisul JC, Skrindo I, Smit HA, Sole D, Sooronbaev T, Spranger O, Stelmach R, Strandberg T, Sunyer J, Thijs C, Todo-Bom A, Triggiani M, Valenta R, Valero AL, van Hage M, Vandenplas O, Vezzani G, Vichyanond P, Viegi G, Wagenmann M, Walker S, Wang DY, Wahn U, Williams DM, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, Mercier J.

    MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy 2015; 70: 1372-1392.

    15. Bousquet PJ, Devillier P, Tadmouri A, Mesbah K, Demoly P, Bousquet J. Clinical Relevance of Cluster Analysis in Phenotyping Allergic Rhinitis in a Real-Life Study. International Archives of Allergy and Immunology 2015; 166: 231-240.

    16. Boutin B, Koskas M, Guillo H, Maingot L, La Rocca M-C, Boule M, Just J, Momas I, Corinne A, Beydon N. Forced expiratory flows’ contribution to lung function interpretation in schoolchildren.

    European Respiratory Journal 2015; 45: 107-115.

    17. Bouzigon E, Nadif R, Le Moual N, Dizier MH, Aschard H, Boudier A, Bousquet J, Chanoine S, Donnay C, Dumas O, Gormand F, Jacquemin B, Just J, Margaritte-Jeannin P, Matran R, Pison C, Rage E, Rava M, Sarnowski C, Smit LAM, Temam S, Varraso R, Vignoud L, Lathrop M, Pin I, Demenais F, Kauffmann F, Siroux V. Genetic and environmental factors of asthma and allergy: Results of the EGEA study.

    Revue Des Maladies Respiratoires 2015; 32: 822-840.

    18. Brunekreef B, Kuenzli N, Pekkanen J, Annesi-Maesano I, Forsberg B, Sigsgaard T, Keuken M, Forastiere F, Barry M, Querol X, Harrison RM. Clean air in Europe: beyond the horizon? (vol 45, pg 7, 2015). European Respiratory Journal 2015; 45: 861-861.

    19. Brunekreef B, Kuenzli N, Pekkanen J, Annesi-Maesano I, Forsberg B, Sigsgaard T, Keuken M, Forastiere F, Barry M, Querol X, Harrison RM.

    Clean air in Europe: beyond the horizon? European Respiratory Journal 2015; 45: 7-10.

    20. Burte E, Bousquet J, Varraso R, Gormand F, Just J, Matran R, Pin I, Siroux V, Jacquemin B, Nadif R. Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study. Plos One 2015; 10.

    21. Buters J, Prank M, Sofiev M, Pusch G, Albertini R, Annesi-Maesano I, Antunes C, Behrendt H, Berger U, Brandao R, Celenk S, Galan C, Grewling L, Jackowiak B, Kennedy R, Rantio-Lehtimaki A, Reese G, Sauliene I, Smith M, Thibaudon M, Weber B, Cecchi L, Grp HW.

    Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season. Journal of Allergy and Clinical Immunology 2015; 136: 87-U179.

    22. Calderon MA, Cox L, Casale TB, Moesges R, Pfaar O, Malling H-J, Sastre J, Khaitov M, Demoly P. The effect of a new communication template on anticipated willingness to initiate or resume allergen immunotherapy: an internet-based patient survey. Allergy Asthma and Clinical Immunology 2015; 11.

    23.

    Calderon MA, Farina H, Duniau S, Demoly PM. Physician-Patient Communication Concerning Allergen Immunotherapy: Impact on Treatment Acceptance and Compliance. Journal of Allergy and Clinical Immunology 2015; 135: AB51-AB51.

    24. Calderon MA, Kleine-Tebbe J, Linneberg A, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, Demoly P. Home Dust Mite Respiratory Allergy: An Overview of Current Therapeutic Strategies. The journal of allergy and clinical immunology In practice 2015; 3: 843-855.

    25. Calderon MA, Linneberg A, Kleine-Tebbe J, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, Demoly P.

    Respiratory allergy caused by home dust mites: What do we really know? Journal of Allergy and Clinical Immunology 2015; 136: 38-48.

    26. Callec R, Lamy C, Perdriolle-Galet E, Patte C, Heude B, Morel O, Grp EM-CCS. Impact on obstetric outcome of third-trimester screening for small-for-gestational-age fetuses. Ultrasound in Obstetrics & Gynecology 2015; 46: 216-220.

    27. Carreiro-Martins P, Rosado-Pinto J, do Ceu Teixeira M, Neuparth N, Silva O, Papoila AL, Khaltaev N, Bousquet J, Annesi-Maesano I.

    Distribution and etiology of chronic respiratory diseases in primary healthcare departments in Cape Verde. Revue D Epidemiologie Et De Sante Publique 2015; 63: 305-313.

    28. Chanoine S, Dumas O, Benmerad M, Pison C, Varraso R, Gormand F, Just J, Le Moual N, Bedouch P, Bousquet J, Kauffmann F, Pin I, Siroux V. Long-term benefits of inhaled corticosteroids in asthma: the propensity score method.

    Pharmacoepidemiology and Drug Safety 2015; 24: 246-255.

    29. Chastang J, Baiz N, Cadwalladder JS, Robert S, Dywer J, Charpin DA, Caillaud D, de Blay F, Raherison C, Lavaud F, Annesi-Maesano I. Postnatal Environmental Tobacco Smoke Exposure Related to Behavioral Problems in Children. Plos One 2015; 10.

    30. Chastang J, Baiz N, Cadwallader JS, Robert S, Dywer JL, Charpin DA, Caillaud D, de Blay F, Raherison C, Lavaud F, Annesi-Maesano I. Postnatal Environmental Tobacco Smoke Exposure Related to Behavioral Problems in Children (vol 10, e0133604, 2015).

    Plos One 2015; 10.

    31. Dallongeville A, Le Cann P, Zmirou-Navier D, Chevrier C, Costet N, Annesi-Maesano I, Blanchard O. Concentration and determinants of molds and allergens in indoor air and home dust of French dwellings. Science of the Entire Environment 2015; 536: 964-972.

    32. D’Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet L-P, Buters JTM, D’Amato M, Dorsano S, Douwes J, Finlay SE, Garrasi D, Gomez M, Haahtela T, Halwani R, Hassani Y, Mahboub B, Marks G, Michelozzi P, Montagni M, Nunes C, Oh JJ-W, Popov TA, Portnoy J, Ridolo E, Rosario N, Rottem M, Sanchez-Borges M, Sibanda E, Sienra-Monge JJ, Vitale C, Annesi-Maesano I.

    Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. The World Allergy Organization journal 2015; 8: 25-25.

    33. D’Amato G, Vitale C, De Martino A, Viegi G, Lanza M, Molino A, Sanduzzi A, Vatrella A, Annesi-Maesano I, D’Amato M. Effects on asthma and respiratory allergy of Climate change and air pollution. Multidisciplinary respiratory medicine 2015; 10: 39-39.

    34. Demoly P, Aubier M, de Blay F, Wessel F, Clerson P, Maigret P.

    Evaluation of patients’ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index — the benefica study. Allergy Asthma and Clinical Immunology 2015; 11.

    35. Demoly P, Calderon MA, Casale TB, Malling H-J, Wahn U. «The worth of pre- and co-seasonal sublingual immunotherapy in pollen-induced allergic rhinoconjunctivitis». Clinical and translational allergy 2015; 5: 18-18.

    36. Demoly P, Lawton S, Villesen H, Virchow JC.

    Immunotherapy with sq-hdm slit-tablet is effective in the treatment of allergic rhinitis and allergic asthma. Internal Medicine Journal 2015; 45: 16-17.

    37. Demoly P, Milgrom H. By the numbers: bringing new drugs for allergic/hypersensitivity diseases to the market. Current Opinion in Allergy and Clinical Immunology 2015; 15: 195-196.

    38. Demoly P, Passalacqua G, Calderon MA, Yalaoui T. Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose. Clinical and translational allergy 2015; 5: 44-44.

    39. Demoly P, Serrano E, Didier A, Bousquet PJ, Mesbah K.

    Listening to and understanding French patients with allergic rhinitis: Observatory OPERA. Revue Francaise D Allergologie 2015; 55: 347-355.

    40. Deschildre A, Marguet C, Langlois C, Pin I, Rittie J-L, Derelle J, Abou Taam R, Fayon M, Brouard J, Dubus JC, Siret D, Weiss L, Pouessel G, Beghin L, Just J. Real-life long-term omalizumab therapy in children with severe allergic asthma. European Respiratory Journal 2015; 46: 856-859.

    41.

    Dinh-Xuan AT, Annesi-Maesano I, Berger P, Chambellan A, Chanez P, Chinet T, Degano B, Delclaux C, Demange V, Didier A, Garcia G, Magnan A, Mahut B, Roche N. Contribution of exhaled nitric oxide measurement in airway inflammation assessment in asthma. A position paper from the French Speaking Respiratory Society. Revue Des Maladies Respiratoires 2015; 32: 193-215.

    42. Doan S, Amat F, Gabison EE, Cochereau I, Just J. Experience with the monoclonal anti IgE antibody Omalizumab in severe refractory vernal keratoconjunctivitis in children.

    Investigative Ophthalmology & Visual Science 2015; 56.

    43. Fontaine C, Amat F, Paluel-Marmont C, Couderc R, Louha M, Annesi-Maesano I, Bernard A, Just J. Could serum pneumoproteins be new biomarkers for asthma phenotypes in infants? Revue Francaise D Allergologie 2015; 55: 312-316.

    44. Foucher F, Hibrand-Saint Oyant L, Hamama L, Sakr S, Nybom H, Baudino S, Caissard JP, Hokanson SC, Byrne DM, Smulder JMS, Desnoye B, Debener T, Bruneau A, De Riek J, Matsumoto S, Torres A, Millan T, Amaya I, Yamada K, Wincker P, Zamir D, Gouzy J, Sargent D, Bendahmane M, Raymond O, Vergne P, Dubois A, Just J.

    Towards the Rose Genome Sequence and Its Use in Research and Breeding. In: Debener T, Linde M, editors. Vi International Symposium on Rose Research and Cultivation; 2015. p. 167-175.

    45. Garcia-Aymerich J, Benet M, Saeys Y, Pinart M, Basagana X, Smit HA, Siroux V, Just J, Momas I, Ranciere F, Keil T, Hohmann C, Lau S, Wahn U, Heinrich J, Tischer CG, Fantini MP, Lenzi J, Porta D, Koppelman GH, Postma DS, Berdel D, Koletzko S, Kerkhof M, Gehring U, Wickman M, Melen E, Hallberg J, Bindslev-Jensen C, Eller E, Kull I, Carlsen KCL, Carlsen KH, Lambrecht BN, Kogevinas M, Sunyer J, Kauffmann F, Bousquet J, Anto JM.

    Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. Allergy 2015; 70: 973-984.

    46. Groupe detude M-L, Groupe d’etude M-L. In Process Citation. Presse medicale (Paris, France : 1983) 2015; 44 Suppl 1: S6-S22.

    47. Groupe detude M-L, Groupe d’etude M-L.

    What is an allergy and how is allergy to pollen classified

    In Process Citation. Presse medicale (Paris, France : 1983) 2015; 44 Suppl 1: S1-5.

    48. Hellings PW, Muraro A, Fokkens W, Mullol J, Bachert C, Canonica GW, Price D, Papadopoulos N, Scadding G, Rasp G, Demoly P, Murray R, Bousquet J. A common language to assess allergic rhinitis control: results from a survey conducted during EAACI 2013 Congress. Clinical and translational allergy 2015; 5: 36-36.

    49. Ibanez G, Bernard JY, Rondet C, Peyre H, Forhan A, Kaminski M, Saurel-Cubizolles M-J, Grp EM-CCS.

    Effects of Antenatal Maternal Depression and Anxiety on Children’s Early Cognitive Development: A Prospective Cohort Study. Plos One 2015; 10.

    50. Just J. Allergic phenotypes in children. Revue Francaise D Allergologie 2015; 55: 108-109.

    51. Just J, Amat F, Deschildre A. Food allergy phenotypes: experiences of the cohorts. Revue Francaise D Allergologie 2015; 55: 474-479.

    52. Just J, Saint Pierre P, Amat F, Gouvis-Echraghi R, Lambert-Guillemot N, Guiddir T, Maesano IA.

    What lessons can be learned about asthma phenotypes in children from cohort studies? Pediatric Allergy and Immunology 2015; 26: 300-305.

    53. Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O’Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Santos AF, Du Toit G, Werfel T, van Wijk RG, Zhang L, Akdis CA.

    International consensus on allergy immunotherapy. Journal of Allergy and Clinical Immunology 2015; 136: 556-568.

    54. Kleine-Tebbe JR, Moen K, Rehm D, Demoly PM. The HDM Slit-Tablet Reduces Symptoms of Home Dust Mite Allergic Rhinitis Independently of Asthma Status and Allergen Sensitisation Type; A Subgroup Analysis of Results from a Dbpc Phase III Trial (MERIT). Journal of Allergy and Clinical Immunology 2015; 135: AB268-AB268.

    55. Klimek L, Hoffmann HJ, Renz H, Demoly P, Werfel T, Matricardi PM, Muraro A, Schmid-Grendelmeier P, Cardona V, Papadopoulos NG.

    Diagnostic test allergens used for in vivo diagnosis of allergic diseases are at risk: a European Perspective. Allergy 2015; 70: 1329-1331.

    56. Maio S, Sarno G, Baldacci S, Annesi-Maesano I, Viegi G. Air quality of nursing homes and its effect on the lung health of elderly residents. Expert Review of Respiratory Medicine 2015; 9: 671-673.

    57. Melchior M, Hersi R, van der Waerden J, Larroque B, Saurel-Cubizolles MJ, Chollet A, Galera C, Grp EM-CCS. Maternal tobacco smoking in pregnancy and children’s socio-emotional development at age 5: The EDEN mother-child birth cohort study.

    European Psychiatry 2015; 30: 562-568.

    58. Moneret-Vautrin AD, Deschildre A, Just J, Bruyere O, van Der Brempt X, Beaudouin E, Elegbede F, Crepet A. Mirabel Project: Description of a French Population of 785 Peanut Allergic or Sensitized Patients. Journal of Allergy and Clinical Immunology 2015; 135: AB34-AB34.

    59. Nakhle MM, Farah W, Ziade N, Abboud M, Coussa-Koniski M-L, Annesi-Maesano I. Beirut Air Pollution and Health Effects — BAPHE study protocol and objectives.

    Multidisciplinary respiratory medicine 2015; 10: 21-21.

    60. Nakhle MM, Farah W, Ziade N, Abboud M, Salameh D, Annesi-Maesano I. Short-term relationships between emergency hospital admissions for respiratory and cardiovascular diseases and fine particulate air pollution in Beirut, Lebanon. Environmental Monitoring and Assessment 2015; 187.

    61. Papadopoulos NG, Bernstein JA, Demoly P, Dykewicz M, Fokkens W, Hellings PW, Peters AT, Rondon C, Togias A, Cox LS.

    Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report. Allergy 2015; 70: 474-494.

    62. Pitsios C, Demoly P, Bilo MB, van Wijk RG, Pfaar O, Sturm GJ, Rodriguez del Rio P, Tsoumani M, Gawlik R, Paraskevopoulos G, Rueff F, Valovirta E, Papadopoulos NG, Calderon MA. Clinical contraindications to allergen immunotherapy: an EAACI position paper. Allergy 2015; 70: 897-909.

    63. Price D, Smith P, Hellings P, Papadopoulos N, Fokkens W, Muraro A, Murray R, Chisholm A, Demoly P, Scadding G, Mullol J, Lieberman P, Bachert C, Mosges R, Ryan D, Bousquet J.

    Current controversies and challenges in allergic rhinitis management. Expert review of clinical immunology 2015; 11: 1205-1217.

    64. Roussel C, Brabant S, Birnbaum J, Bourrain JL, Demoly P, Duhamel A, Wallaert B. Yellow jacket venom immunotherapy: The influence of maintenance dose on the immunologic response. Revue Francaise D Allergologie 2015; 55: 280-287.

    65. Saadeh D, Salameh P, Caillaud D, Charpin D, De Blay F, Kopferschmitt C, Lavaud F, Annesi-Maesano I, Baldi I, Raherison C. Prevalence and association of asthma and allergic sensitization with dietary factors in schoolchildren: data from the french six cities study.

    Bmc Public Health 2015; 15.

    66. Schrijvers R, Chiriac AM, Demoly P. Allergy Workup for Suspected Folic Acid Hypersensitivity. Journal of Investigational Allergology and Clinical Immunology 2015; 25: 233-236.

    67. Schrijvers R, Gilissen L, Chiriac AM, Demoly P. Pathogenesis and diagnosis of delayed-type drug hypersensitivity reactions, from bedside to bench and back. Clinical and translational allergy 2015; 5: 31-31.

    68. Sigsgaard T, Forsberg B, Annesi-Maesano I, Blomberg A, Bolling A, Boman C, Bonlokke J, Brauer M, Bruce N, Heroux M-E, Hirvonen M-R, Kelly F, Kuenzli N, Lundback B, Moshammer H, Noonan C, Pagels J, Sallsten G, Sculier J-P, Brunekreef B.

    Health impacts of anthropogenic biomass burning in the developed world. European Respiratory Journal 2015; 46: 1577-1588.

    69. Tanno LK, Calderon M, Papadopoulos NG, Demoly P, of EWTfoaGC, Hypersensitivity/Allergic d. Mapping hypersensitivity/allergic diseases in the International Classification of Diseases (ICD)-11: cross-linking terms and unmet needs. Clinical and translational allergy 2015; 5: 20-20.

    70. Tanno LK, Calderon MA, Demoly P. Making allergic and hypersensitivity conditions visible in the International Classification of Diseases-11.

    Asia Pacific allergy 2015; 5: 193-196.

    71. Tanno LK, Calderon MA, Goldberg BJ, Gayraud J, Bircher AJ, Casale T, Li J, Sanchez-Borges M, Rosenwasser LJ, Pawankar R, Papadopoulos NG, Demoly P. Constructing a classification of hypersensitivity/allergic diseases for ICD-11 by crowdsourcing the allergist community. Allergy 2015; 70: 609-615.

    72. van der Waerden J, Galera C, Larroque B, Saurel-Cubizolles M-J, Sutter-Dallay A-L, Melchior M, Grp EM-CCS.

    Maternal Depression Trajectories and Children’s Behavior at Age 5 Years. Journal of Pediatrics 2015; 166: 1440-+.

    73. Villani A, Demoly P, Nicolas J-F. Drug hypersensitivity: definitions and mechanisms. La Revue du praticien 2015; 65: 969-971.

    74. Wang Y, Qi S, Zhu R, Chiriac AM, Demoly P. Which clinical indicators for the control of allergic rhinitis? Revue Francaise D Allergologie 2015; 55: 194-195.

    75. Zugna D, Galassi C, Annesi-Maesano I, Baiz N, Barros H, Basterrechea M, Correia S, Duijts L, Esplugues A, Fantini MP, Forastiere F, Gascon M, Gori D, Inskip H, Larsen PS, Mommers M, Andersen A-MN, Penders J, Petersen MS, Pike K, Porta D, Sonnenschein-van der Voort A, Steuerwald U, Sunyer J, Torrent M, Vrijheid M, Richiardil L, Rusconi F.

    Maternal complications in pregnancy and wheezing in early childhood: a pooled analysis of 14 birth cohorts. International Journal of Epidemiology 2015; 44: 199-208.

    Allergies are caused by foreign substances constantly bombarding your body—such as dander, pollen, dust, mold, chemicals, and certain foods. In response, your body has developed an immune system that produces antibodies to protect you. But sometimes immune systems overreact, producing in excess a certain antibody known as IgE, which causes allergic reactions.

    For those Americans who experience allergies every year—an estimated 1 in 5 people—there is always the hope that they can discover sustainable relief from the sneezing, coughing, runny noses, and watery, itchy eyes, and numerous other symptoms allergies can cause.

    We’re here to let you know that we can provide you the most up-to-date and effective techniques for managing your allergies, helping you understand more about the allergies that you or a loved one might be experiencing.

    Our allergy specialists work with patients of every age populations, so if your allergy concerns are for yourself, a young kid, or a more senior member of the family, we’ll proudly provide you the same comprehensive approach to allergy care your friends and neighbors own come to expect from Ear Nose & Throat Medical and Surgical Group.

    Allergens from this family

    The major birch pollen allergen, Bet v 1, is a member of the PR-10 family.

    Closely-related, cross-reactive allergens were found in the pollen of other trees from the order Fagales such as hazel, alder, oak and chestnut. Numerous birch pollen-allergic patients show allergic reactions to various fruits and vegetables, which are caused by IgE cross-reactivity between Bet v 1 and homologous allergens from plant foods [10]. Most Bet v 1-related food allergens were found in members of certain plant families: Rosaceae (apple, pear, rock fruits), Apiaceae (celery, carrot), and Fabaceae (soybean, peanut). Only two Bet v 1-related allergens were identified exterior the PR-10 subfamily. Vig r 6 is a minor allergen from mung bean and member of the cytokinin-specific binding proteins subfamily, a little subfamily distantly related to the PR-10 group [11].

    Act d 11 is a minor kiwifruit allergen belonging to the MLP/RRP subfamily [12].

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    What are my treatment options?

    There are a number of treatment options available that may offer some relief from allergy symptoms. These options include avoidance, prescription and over-the-counter medications, and allergy immunotherapy (allergy shots or sublingual drops).

    Subcutaneous Immunotherapy (SCIT)

    1. Treatment: Injections of allergen extract
    2. istered: In your physician’s office
    3. Frequency: Weekly, for a 30-minute appointment
    4. Payment: Covered by most insurance plans

    Sublingual Immunotherapy (SLIT)

    1. Treatment: Drops of allergen taken orally
    2. istered: In your home
    3. Frequency: Quarterly, to pick up the next vial of drops
    4. Payment: Not covered by insurance; out-of-pocket expense for patient

    If you feel that your allergy medication and avoidance measures do not assist as much as you would love, you should consult one of our ENT Allergist specialists regarding evaluation and individualized treatment options available to you.

    How Do I Manage My Allergies?

    Avoid the allergen(s) – While this may work in some situations, some substances such as pollen are hard to avoid
    Treat the symptoms – Medication can provide you a measure of relief from your allergy symptoms, but it does nothing to address the root of the problem
    Use immunotherapy – Alter the body’s reaction to the allergen(s).

    To desensitize your immune system’s reaction to the effect of the offending allergen is the only treatment method known to cure your allergy

    With immunotherapy:

    1. You may use fewer ill days at work.
    2. Living your life as you desire to becomes easier.
    3. Other diseases such as asthma and sinusitis may be better controlled.
    4. You may use fewer medications.

    Those who suffer from one allergy may be more vulnerable to others, as allergens can stack up and increase symptoms. Our immunotherapy program provides patients with a testing and treatment plan that can improve overall health and well-being.

    Links to Pfam

    Family-defining Pfam domains (at least one of these domains is present in each family member):

    Pfam domain Pfam clan
    PF00407 Pathogenesis-related protein Bet v I family CL0209 Bet V 1 love

    What are My Testing Options?

    The first step in treating an allergy is to discover out what is causing the reaction.

    Radioallergosorbent Testing (RAST) involves sending a sample of your blood to a lab to be tested for allergens.

    We don’t typically recommend this method as allergens may not show up in blood and can be missed.

    Modified Quantitative Testing (MQT) is a state-of-the-art method. It combines both intradermal testing and skin-prick testing. This allows the healthcare provider to precisely identify the degree of reactivity. This is our preferred testing method as recommended by the American Academy of Otolaryngic Allergy (AAOA).

    Who could benefit?

    Allergy shots or sublingual drops are used for people with respiratory allergies caused by pollens, animal dander, molds and dust mites.

    Speak with your physician about your allergies and the individualized treatment options available to you. If you ponder you may be a candidate for immunotherapy, enquire your doctor about it today.


    Learn More About Allergy Care


    You may study to live with your allergies- but you don’t own to! Contact us today to study more about your allergies and to discover out if immunotherapy is correct for you.

    [top]

    Common Symptoms of Allergies

    1. Ears – Fluid in the middle ear, recurrent infections
    2. Sinus – Sinus pain, pressure, recurrent infection
    3. Lungs – Shortness of breath, wheezing, chest tightness, coughing
    4. Eyes – Itching, redness, swelling, tearing
    5. Nose – Itching, congestion, sneezing, postnasal drip
    6. Skin – Itching, welts, hives, blistery rash
    7. Other – Headaches, fatigue, hyperactivity, depression

    Common Causes of Allergies

    1. Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database
      CNS Drugs.

      2018 (32-7) 673-684
      Billioti de Gage S, Collin C, Le-Tri T, Pariente A, Bégaud B, Verdoux H, Dray-Spira R, Zureik M.
      PubMed citation

    2. The economic burden of preventable adverse drug reactions: a systematic review of observational studies
      Expert Opin Drug Saf. 2018 (17-7) 681-695
      Formica D, Sultana J, Cutroneo PM, Lucchesi S, Angelica R, Crisafulli S, Ingrasciotta Y, Salvo F, Spina E, Trifirò G.
      PubMed citation

    3. Risk of hospital admission for liver injury in users of NSAIDs and nonoverdose paracetamol: Preliminary results from the EPIHAM study
      Pharmacoepidemiol Drug Saf.

      2018 (27-11) 1174-1181
      Gulmez SE, Unal US, Lassalle R, Chartier A, Grolleau A, Moore N.
      PubMed citation

    4. [From psychoactive medicines to addictovigilance in French Public Health Code (1990-2017)]
      Therapie. 2018 (ahead of print)
      Baumevieille M, Perri-Plandé J, Miremont-Salamé G, Daveluy A, Haramburu F.
      PubMed citation

    5. Antibiotics associated with acquisition of carbapenem-resistant Pseudomonas aeruginosa in ICUs: a multicentre nested case-case-control study
      J Antimicrob Chemother.

      2018 (ahead of print)
      Coppry M, Jeanne-Leroyer C, Noize P, Dumartin C, Boyer A, Bertrand X, Dubois V, Rogues AM.
      PubMed citation

    6. Risk of Serious Trauma with Glucose-Lowering Drugs in Older Persons: A Nested Case-Control Study
      J Am Geriatr Soc. 2018 (66-11) 2086-2091
      Arnaud M, Pariente A, Bezin J, Bégaud B, Salvo F.
      PubMed citation

    7. [Use and misuse of benzodiazepines out of France]
      Presse Med.

      2018 (47-10) 882-885
      Tournier M, Pariente A, Bégaud B, Bénard-Laribière A.
      PubMed citation

    8. Propensity Score-Based Approaches in High Dimension for Pharmacovigilance Signal Detection: an Empirical Comparison on the French Spontaneous Reporting Database
      Front Pharmacol. 2018 (9) 1010
      Courtois É, Pariente A, Salvo F, Volatier É, Tubert-Bitter P, Ahmed I.
      PubMed citation

    9. Biomonitoring of occupational exposure to 5-FU by assaying ?-fluoro-?-alanine in urine with a highly sensitive UHPLC-MS/MS method
      Analyst.

      2018 (143-17) 4110-4117
      Dhersin A, Atgé B, Martinez B, Titier K, Rousset M, Sidatt Cheikh El Moustaph M, Verdun-Esquer C, Molimard M, Villa A, Canal-Raffin M.
      PubMed citation

    10. Systematic review of association between critical errors in inhalation and health outcomes in asthma and COPD
      NPJ Prim Care Respir Med. 2018 (28-1) 43
      Kocks JWH, Chrystyn H, van der Palen J, Thomas M, Yates L, Landis SH, Driessen MT, Gokhale M, Sharma R, Molimard M.
      PubMed citation

    11. Baseline results from the European non-interventional Antipsychotic Endless acTing injection in schizOphrenia (ALTO) study
      Eur Psychiatry.

      2018 (52) 85-94
      Llorca PM, Bobes J, Fleischhacker WW, Heres S, Moore N, Bent-Ennakhil N, Sapin C, Loze JY, Nylander AG, Patel MX.
      PubMed citation

    12. Non-communicable diseases in Indian slums: re-framing the Social Determinants of Health
      Glob Health Action. 2018 (11-1)
      Lumagbas LB, Coleman HLS, Bunders J, Pariente A, Belonje A, de Cock Buning T.
      PubMed citation

    13. Hepatitis B vaccination and the putative risk of central demyelinating diseases — A systematic review and meta-analysis
      Vaccine. 2018 (36-12) 1548-1555
      Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo IC, De Ponti F, Bégaud B.
      PubMed citation

    14. Interest of pharmacoepidemiology for the study of inhaled drugs
      Therapie.

      2018 (ahead of print)
      Molimard M, Girodet PO, Van Ganse E.
      PubMed citation

    15. [Should the duration of treatment be limited using benzodiazepines?]
      Presse Med. 2018 (47-10) 892-898
      Vorspan F, Barré T, Pariente A, Montastruc F, Tournier M.
      PubMed citation

    16. Tamper-resistant prescription forms for narcotics in France: should we generalise them?
      Fundam Clin Pharmacol. 2018 (32-5) 571-577
      Daveluy A, Sauvaget L, Bastien A, Lapeyre-Mestre M, Collin C, Richard N, Haramburu F.
      PubMed citation

    17. Use of lipid-lowering drugs and the risk of cataract: a population-based nested case-control study
      Clin Pharmacol Ther.

      2018 (105-2) 458-465
      Bezin J, Mansiaux Y, Noize P, Salvo F, Bégaud B, Pariente A.
      PubMed citation

    18. Use of benzodiazepines and z-drugs not compliant with guidelines and associated factors: a population-based study
      Eur Arch Psychiatry Clin Neurosci. 2018 (ahead of print)
      Panes A, Pariente A, Bénard-Laribière A, Lassalle R, Dureau-Pournin C, Lorrain S, Tournier M, Fourrier-Réglat A.
      PubMed citation

    19. Pharmacoepidemiology of non-steroidal anti-inflammatory drugs
      Therapie.

      2018 (74-2) 271-277
      Moore N, Duong M, Gulmez SE, Blin P, Droz C.
      PubMed citation

    20. Atropinic (Anticholinergic) Burden in Antipsychotic-Treated Patients
      Fundam Clin Pharmacol. 2018 (32-1) 114-119
      Montastruc F, Benevent J, Touafchia A, Chebane L, Araujo M, Guitton-Bondon E, Durrieu G, Arbus C, Schmitt L, Bé gaud B, Montastruc JL.
      PubMed citation

    21. Coronary Events After Dispensing of Ibuprofen: A Propensity Score-Matched Cohort Study Versus Paracetamol in the French Nationwide Claims Database Sample
      Drug Saf. 2018 (41-11) 1049-1058
      Duong M, Abouelfath A, Lassalle R, Droz C, Blin P, Moore N.
      PubMed citation

    22. Immunotherapy with grass pollen tablets reduces medication dispensing for allergic rhinitis and asthma: a retrospective database study in France
      Allergy.

      2018 (ahead of print)
      Devillier P, Molimard M, Ansolabehere X, Bardoulat I, Coulombel N, Maurel F, Le Jeunne P, Demoly P.
      PubMed citation

    23. children: A pilot study
      Environ Res. 2018 (169) 189-195
      Raherison C, Baldi I, Pouquet M, Berteaud E, Moesch C, Bouvier G, Canal-Raffin M.
      PubMed citation

    24. Human papillomavirus vaccine and demyelinating diseases-A systematic review and meta-analysis
      Pharmacol Res. 2018 (132) 108-118
      Mouchet J, Salvo F, Raschi E, Poluzzi E, Antonazzo IC, De Ponti F, Bégaud B.
      PubMed citation

    25. Comparative effectiveness of direct oral anticoagulants versus low-molecular weight heparins for the prevention of venous thromboembolism after entire hip or knee replacement: a nationwide database cohort study
      Pharmacol Res.

      2018 (141) 201-207
      Blin P, Samama CM, Sautet A, Benichou J, Lignot-Maleyran S, Lamarque S, Lorrain S, Lassalle R, Droz-Perroteau C, Mismetti P, Moore N.
      PubMed citation

    26. Inclusion of elderly or frail patients in randomized controlled trials of targeted therapies for the treatment of metastatic colorectal cancer: A systematic review
      J Geriatr Oncol. 2018 (9-1) 15-23
      Gouverneur A, Salvo F, Berdaï D, Moore N, Fourrier-Réglat A, Noize P.
      PubMed citation

    27. Pharmacovigilance of sodium-glucose co-transporter-2 inhibitors: What a clinician should know on disproportionality analysis of spontaneous reporting systems
      Nutr Metab Cardiovasc Dis.

      2018 (28-6) 533-542
      Raschi E, Poluzzi E, Salvo F, Pariente A, De Ponti F, Marchesini G, Moretti U.
      PubMed citation

    28. Omalizumab effectiveness in patients with severe allergic asthma according to blood eosinophil count: the STELLAIR study
      Eur Respir J. 2018 (51) 1702523
      Humbert M, Taillé C, Mala L, Le Gros V, Just J, Molimard M.
      PubMed citation

    29. Assessment of the state of pharmacovigilance in the South-South zone of Nigeria using WHO pharmacovigilance indicators
      BMC Pharmacol Toxicol.

      2018 (19-1) 27
      Opadeyi AO, Fourrier-Réglat A, Isah AO.
      PubMed citation

    30. Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
      Br J Clin Pharmacol. 2018 (84-8) 1764-1775
      Bénard-Laribière A, Pambrun E, Sutter-Dallay AL, Gautier S, Hurault-Delarue C, Damase-Michel C, Lacroix I, Bégaud B, Pariente A.
      PubMed citation

    31. Previous Drug Exposure in Patients Hospitalised for Acute Liver Injury: A Case-Population Study in the French National Healthcare Data System.
      Drug Saf.

      2018 (ahead of print)
      Moore N, Duret S, Grolleau A, Lassalle R, Barbet V, Duong M, Thurin N, Droz-Perroteau C, Gulmez SE.
      PubMed citation

    32. Food
    33. Secondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database
      Atherosclerosis. 2018 (ahead of print)
      Blin P, Dureau-Pournin C, Benichou J, Bonello L, Dallongeville J, Danchin N, Falissard B, Thomas-Delecourt F, Jové J, Lassalle R, Droz C, Moore N.
      PubMed citation

    34. Detection of drug safety signals from clinical trials data: Role of SUSARs
      Pharmacol Res.

      2018 (131) 218-223
      Perez C, Olivier P, Lortal B, Duranton S, Montastruc JL, Colin AL, Toulza E, Becker M, Hamy L, Crepin S, Roussillon C, Gimbert A, Petitpain N, Salvo F.
      PubMed citation

    35. Authors’ Reply to Cohen et al.’s Comment on «Central Demyelinating Diseases after Vaccination Against Hepatitis B Virus: A Disproportionality Analysis within the VAERS Database»
      Drug Saf. 2018 (41-12) 1429-1430
      Mouchet J, Bégaud B.
      PubMed citation

    36. [Understanding the distrust towards the assessment of medicines.

      Beyond conflict of interests]
      Therapie. 2018 (73-4) 341-348
      Tournay V, Pariente A.
      PubMed citation

    37. Inhaled triple therapy in chronic obstructive pulmonary disease
      Lancet. 2018 (392-10153) 1112
      Molimard M, Girodet PO, Moore N.
      PubMed citation

    38. The Social Impact of Suspected Adverse Drug Reactions: An analysis of the Canada Vigilance Spontaneous Reporting Database
      Drug Saf. 2018 (42-1) 27-34
      Castillon G, Salvo F, Moride Y.
      PubMed citation

    39. [Benzodiazepine use and misuse in France]
      Presse Med.

      2018 (47-10) 878-881
      Bénard-Laribière A, Pariente A.
      PubMed citation

    40. Central Demyelinating Diseases after Vaccination Against Hepatitis B Virus: A Disproportionality Analysis within the VAERS Database
      Drug Saf. 2018 (41-8) 767-774
      Mouchet J, Bégaud B.
      PubMed citation

    41. Interest and challenges of pharmacoepidemiology for the study of drugs used in diabetes
      Therapie. 2018 (74-2) 255-260
      Salvo F, Faillie JL.
      PubMed citation

    42. Antipsychotics use: 2006-2013 trends in prevalence and incidence and characterization of users
      Eur J Clin Pharmacol.

      2018 (74-5) 619-626
      Montastruc F, Bénard-Laribière A, Noize P, Pambrun E, Diaz-Bazin F, Tournier M, Bégaud B, Pariente A.
      PubMed citation

    43. High throughput routine determination of 17 tyrosine kinase inhibitors by LC-MS/MS
      J Pharm Biomed Anal. 2018 (150) 112-120
      Merienne C, Rousset M, Ducint D, Castaing N, Titier K, Molimard M, Bouchet S.
      PubMed citation

    44. Breakthrough invasive aspergillosis and diagnostic accuracy of serum galactomannan enzyme immune assay during acute myeloid leukemia induction chemotherapy with posaconazole prophylaxis
      Oncotarget.

      2018 (9-42) 26724-26736
      Calmettes C, Gabriel F, Blanchard E, Servant V, Bouchet S, Kabore N, Forcade E, Leroyer C, Bidet A, Latrabe V, Leguay T, Vigouroux S, Tabrizi R, Breilh D, Accoceberry I, de Lara MT, Pigneux A, Milpied N, Dumas PY.
      PubMed citation

    45. Comparative effectiveness and safety of standard or reduced dose dabigatran versus rivaroxaban in non-valvular atrial fibrillation
      Clin Pharmacol Ther. 2018 (ahead of print)
      Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
      PubMed citation

    46. [Psychoactive substances use in Réunion Island and Mayotte, French departments in Indian Ocean]
      Therapie.

      2018 (73-5) 419-427
      Daveluy A, Haramburu F.
      PubMed citation

    47. [The nocebo effect: Various aspects and consequences in clinical practice]
      Rev Med Interne. 2018 (39-5) 315-320
      Mouly S, Bergmann JF, Molimard M.
      PubMed citation

    48. Dust Mites
    49. Diagnostic accuracy of the International Classification of Diseases, Tenth Revision, codes of heart failure in an istrative database
      Pharmacoepidemiol Drug Saf. 2018 (ahead of print)
      Bosco-Lévy P, Duret S, Picard F, Dos Santos P, Puymirat E, Gilleron V, Blin P, Chatellier G, Looten V, Moore N.
      PubMed citation

    50. Gastrointestinal safety and tolerability of oral non-aspirin over-the-counter analgesics
      Postgrad Med.

      2018 (130-2) 188-199
      Moore N, Scheiman JM.
      PubMed citation

    51. Increased endless QT and torsade de pointes reporting on tamoxifen compared with aromatase inhibitors
      Heart. 2018 (104-22) 1859-1863
      Grouthier V, Lebrun-Vignes B, Glazer AM, Touraine P, Funck-Brentano C, Pariente A, Courtillot C, Bachelot A, Roden DM, Moslehi JJ, Salem JE.
      PubMed citation

    52. Adverse drug reactions of analgesic medicines: analysis of the Romanian pharmacovigilance database
      Fundam Clin Pharmacol. 2018 (32-3) 330-336
      Cazacu I, Stroe R, Dondera R, Mogosan C, Haramburu F, Fourrier-Réglat A, Loghin F.
      PubMed citation

    53. A history of pharmacoepidemiology
      Therapie.

      2018 (74-2) 175-179
      Bégaud B.
      PubMed citation

    54. [Use and misuse of benzodiazepines in patients with psychiatric disorders]
      Presse Med. 2018 (47-10) 886-891
      Panes A, Fourrier-Réglat A, Verdoux H, Tournier M.
      PubMed citation

    55. Pollen (Trees, Grasses, Weeds)
    56. Comorbidities and COPD severity in a clinic-based cohort
      BMC Pulm Med. 2018 (18-1) 117
      Raherison C, Ouaalaya EH, Bernady A, Casteigt J, Nocent-Eijnani C, Falque L, Le Guillou F, Nguyen L, Ozier A, Molimard M.
      PubMed citation

    57. Patterns of Use, Safety, and Effectiveness of Targeted Therapies in First-Line Treatment of Metastatic Colorectal Cancer According to Age: The STROMBOLI Cohort Study
      Clin Colorectal Cancer.

      2018 (18-1) e150-e162
      Gouverneur A, Coutureau J, Jové J, Rouyer M, Grelaud A, Duc S, Gérard S, Smith D, Ravaud A, Droz C, Bernard MA, Lassalle R, Forrier-Réglat A, Noize P; ETNA study group and the EREBUS study group.
      PubMed citation

    58. Non-bleeding Adverse Events with the Use of Direct Oral Anticoagulants: A Sequence Symmetry Analysis
      Drug Saf. 2018 (41-9) 881-897
      Maura G, Billionnet C, Coste J, Weill A, Neumann A, Pariente A.
      PubMed citation

    59. Impact of cancer diagnosis on persistence of oral antidiabetic drugs
      Diabetes Res Clin Pract.

      2018 (139) 323-330
      Létinier L, Mansiaux Y, Pariente A, Fourrier-Réglat A.
      PubMed citation

    60. Effectiveness of Cetuximab as First-Line Therapy for Patients With Wild-Type KRAS and Unresectable Metastatic Colorectal Cancer in Real-Life Practice: Results of the EREBUS Cohort
      Clin Colorectal Cancer. 2018 (17-2) 129-139
      Rouyer M, François E, Cunha AS, Monnereau A, Noize P, Robinson P, Droz-Perroteau C, Le Monies de Sagazan A, Jové J, Lassalle R, Moore N, Fourrier-Réglat A, Smith D; EREBUS Study Group.
      PubMed citation

    61. Insect Stings/Bites
    62. Reply to ‘The simple misuse of antidepressants during pregnancy is depressing’
      Br J Clin Pharmacol.

      2018 (84-10) 2447-2448
      Bénard-Laribière A, Sutter-Dallay AL, Pariente A.
      PubMed citation

    63. Effectiveness and safety of 110 or 150 mg dabigatran versus vitamin K antagonists in non-valvular atrial fibrillation
      Br J Clin Pharmacol. 2018 (ahead of print)
      Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
      PubMed citation

    64. Mold
    65. Trends in attention-deficit hyperactivity disorder medication use: a retrospective observational study using population-based databases
      Lancet Psychiatry.

      2018 (5-10) 824-835
      Raman SR, Man KKC, Bahmanyar S, Berard A, Bilder S, Boukhris T, Bushnell G, Crystal S, Furu K, KaoYang YH, Karlstad Ø, Kieler H, Kubota K, Lai EC, Martikainen JE, Maura G, Moore N, Montero D, Nakamura H, Neumann A, Pate V, Pottegård A, Pratt NL, Roughead EE, Macias Saint-Gerons D, Stürmer T, Su CC, Zoega H, Sturkenbroom MCJM, Chan EW, Coghill D, Ip P, Wong ICK.
      PubMed citation

    66. An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
      Allergy Asthma Clin Immunol.

      2018 (14) 38
      Blin P, Demoly P, Drouet M, Falissard B, Lignot-Maleyran S, Maizi H, Lorrain S, Lassalle R, Droz-Perroteau C, Moore N, Molimard M.
      PubMed citation

    67. [Will be 60 years the age of reason?]
      Presse Med. 2018 (47-10) 870-871
      Bégaud B.
      PubMed citation

    68. Cardiovascular toxicities associated with immune checkpoint inhibitors: an observational, retrospective, pharmacovigilance study
      Lancet Oncol. 2018 (19-12) 1579-1589
      Salem JE, Manouchehri A, Moey M, Lebrun-Vignes B, Bastarache L, Pariente A, Gobert A, Spano JP, Balko JM, Bonaca MP, Roden DM, Johnson DB, Moslehi JJ.
      PubMed citation

    69. Antidepressants during pregnancy: a French drug utilisation study in EFEMERIS cohort
      Eur Arch Psychiatry Clin Neurosci.

      2018 (ahead of print)
      Hurault-Delarue C, Lacroix I, Bénard-Laribière A, Montastruc JL, Pariente A, Damase-Michel C.
      PubMed citation

    70. Animal Hair/Dander
    71. Rhabdomyolysis after co-istration of a statin and fusidic acid: an analysis of the literature and of the WHO database of adverse drug reactions
      Br J Clin Pharmacol. 2018 (84-5) 1057-1063
      Deljehier T, Pariente A, Miremont-Salamé G, Haramburu F, Nguyen L, Rubin S, Rigothier C, Théophile H.
      PubMed citation

    72. Monitoring of drug misuse or potential misuse in a nationwide healthcare insurance database: A cross-sectional study in France
      Therapie.

      2018 (ahead of print)
      Bénard-Laribière A, Noize P, Girodet PO, Lassalle R, Dureau-Pournin C, Droz-Perroteau C, Fourrier-Réglat A, Salvo F, Bezin J, Pariente A; DRUGS-2M study group.
      PubMed citation

    73. Anticholinergic drug use and cognitive performances in middle age: findings from the CONSTANCES cohort
      J Neurol Neurosurg Psychiatry. 2018 (89-10) 1107-1115
      Ziad A, Olekhnovitch R, Ruiz F, Berr C, Bégaud B, Goldberg M, Zins M, Mura T.
      PubMed citation

    Did you know? 60 million people in the U.S. suffer from allergies. That’s enough people to classify as an allergy epidemic!

    Biochemical properties

    Bet v 1-related proteins are widely distributed among vascular plants.

    The family was classified by sequence similarity into two large and several little subfamilies showing low levels of sequence identity but conserved structures [1]. The largest of these is the pathogenesis-related protein family PR-10 [2]. The expression of these proteins is either induced by pathogen attack or abiotic stress or developmentally regulated. PR-10 proteins are expressed in high concentrations in reproductive tissues such as pollen, seeds and fruits. The biochemical function of most PR-10 proteins is unknown. For some PR-10 subfamily members an enzymatic function as ribonuclease [3] or oxidative coupling enzyme involved in biosynthesis of secondary metabolites was shown [4].

    Love every members of the Bet v 1-family, PR-10 proteins contain a large ligand-binding cavity that can accommodate diverse ligands including plant steroids [5], cytokinins [6] and flavonoids [7]. The other large subfamily is a group of major latex proteins and ripening-related proteins (MLP/RRP) first described in the latex of opium poppy [8]. Their biologic function is unknown, but they appear to own a role in defense against biotic and abiotic stress [9].

    Links to Wikipedia

    [top]

    If you own updates or corrections for this entry, please contact the site istrator: christian.radauer@meduniwien.ac.at .

  • Risk of Serious Trauma with Glucose-Lowering Drugs in Older Persons: A Nested Case-Control Study
    J Am Geriatr Soc. 2018 (66-11) 2086-2091
    Arnaud M, Pariente A, Bezin J, Bégaud B, Salvo F.
    PubMed citation

  • [From psychoactive medicines to addictovigilance in French Public Health Code (1990-2017)]
    Therapie. 2018 (ahead of print)
    Baumevieille M, Perri-Plandé J, Miremont-Salamé G, Daveluy A, Haramburu F.
    PubMed citation

  • [Will be 60 years the age of reason?]
    Presse Med.

    2018 (47-10) 870-871
    Bégaud B.
    PubMed citation

  • A history of pharmacoepidemiology
    Therapie. 2018 (74-2) 175-179
    Bégaud B.
    PubMed citation

  • Monitoring of drug misuse or potential misuse in a nationwide healthcare insurance database: A cross-sectional study in France
    Therapie. 2018 (ahead of print)
    Bénard-Laribière A, Noize P, Girodet PO, Lassalle R, Dureau-Pournin C, Droz-Perroteau C, Fourrier-Réglat A, Salvo F, Bezin J, Pariente A; DRUGS-2M study group.
    PubMed citation

  • Patterns of antidepressant use during pregnancy: a nationwide population-based cohort study
    Br J Clin Pharmacol.

    2018 (84-8) 1764-1775
    Bénard-Laribière A, Pambrun E, Sutter-Dallay AL, Gautier S, Hurault-Delarue C, Damase-Michel C, Lacroix I, Bégaud B, Pariente A.
    PubMed citation

  • [Benzodiazepine use and misuse in France]
    Presse Med. 2018 (47-10) 878-881
    Bénard-Laribière A, Pariente A.
    PubMed citation

  • Reply to ‘The simple misuse of antidepressants during pregnancy is depressing’
    Br J Clin Pharmacol. 2018 (84-10) 2447-2448
    Bénard-Laribière A, Sutter-Dallay AL, Pariente A.
    PubMed citation

  • Use of lipid-lowering drugs and the risk of cataract: a population-based nested case-control study
    Clin Pharmacol Ther.

    2018 (105-2) 458-465
    Bezin J, Mansiaux Y, Noize P, Salvo F, Bégaud B, Pariente A.
    PubMed citation

  • Antidepressants and Hepatotoxicity: A Cohort Study among 5 Million Individuals Registered in the French National Health Insurance Database
    CNS Drugs. 2018 (32-7) 673-684
    Billioti de Gage S, Collin C, Le-Tri T, Pariente A, Bégaud B, Verdoux H, Dray-Spira R, Zureik M.
    PubMed citation

  • An observational cohort study of the use of five-grass-pollen extract sublingual immunotherapy during the 2015 pollen season in France
    Allergy Asthma Clin Immunol.

    2018 (14) 38
    Blin P, Demoly P, Drouet M, Falissard B, Lignot-Maleyran S, Maizi H, Lorrain S, Lassalle R, Droz-Perroteau C, Moore N, Molimard M.
    PubMed citation

  • Secondary prevention of acute coronary events with antiplatelet agents (SPACE-AA): One-year real-world effectiveness and safety cohort study in the French nationwide claims database
    Atherosclerosis. 2018 (ahead of print)
    Blin P, Dureau-Pournin C, Benichou J, Bonello L, Dallongeville J, Danchin N, Falissard B, Thomas-Delecourt F, Jové J, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Effectiveness and safety of 110 or 150 mg dabigatran versus vitamin K antagonists in non-valvular atrial fibrillation
    Br J Clin Pharmacol.

    2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
    PubMed citation

  • Comparative effectiveness and safety of standard or reduced dose dabigatran versus rivaroxaban in non-valvular atrial fibrillation
    Clin Pharmacol Ther. 2018 (ahead of print)
    Blin P, Dureau-Pournin C, Cottin Y, Bénichou J, Mismetti P, Abouelfath A, Lassalle R, Droz C, Moore N.
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    4. Avignon A, Fesler P, Daien C, Costa D, Picot M-C, Roubille F, Sultan A, Viarouge-Reunier C, Attalin V, Badin M, Boegner C, Demoly P, Dauzat M, David M, Lognos B, Morel J, Pasquie J-L, Ribstein J, Granier S, Combe B, Mercier J, Bourret R, Bousquet J. In Process Citation. Presse medicale (Paris, France : 1983) 2015; 44 Suppl 1: S47-54.

    5.

    Baldacci S, Maio S, Cerrai S, Sarno G, Baiz N, Simoni M, Annesi-Maesano I, Viegi G, Study H. Allergy and asthma: Effects of the exposure to particulate matter and biological allergens. Respiratory Medicine 2015; 109: 1089-1104.

    6. Bentayeb M, Norback D, Bednarek M, Bernard A, Cai G, Cerrai S, Eleftheriou KK, Gratziou C, Holst GJ, Lavaud F, Nasilowski J, Sestini P, Sarno G, Sigsgaard T, Wieslander G, Zielinski J, Viegi G, Annesi-Maesano I, Study G. Indoor air quality, ventilation and respiratory health in elderly residents Living in nursing homes in Europe. European Respiratory Journal 2015; 45: 1228-1238.

    7.

    Bergmann K-C, Demoly P, Abiteboul K, Zeldin RK. Clinical relevance of home dust mite immunotherapy Reply. Journal of Allergy and Clinical Immunology 2015; 135: 288-289.

    8. Bourret R, Bousquet J, Mercier J, Camuzat T, Bedbrook A, Demoly P, Caimmi D, Laune D, Arnavielhe S. MASK-rhinitis, a single tool for integrated care pathways in allergic rhinitis. World hospitals and health services : the official journal of the International Hospital Federation 2015; 51: 36-39.

    9.

    Bousquet J, Anto JM, Wickman M, Keil T, Valenta R, Haahtela T, Carlsen KL, van Hage M, Akdis C, Bachert C, Akdis M, Auffray C, Annesi-Maesano I, Bindslev-Jensen C, Cambon-Thomsen A, Carlsen KH, Chatzi L, Forastiere F, Garcia-Aymerich J, Gehrig U, Guerra S, Heinrich J, Koppelman GH, Kowalski ML, Lambrecht B, Lupinek C, Maier D, Melen E, Momas I, Palkonen S, Pinart M, Postma D, Siroux V, Smit HA, Sunyer J, Wright J, Zuberbier T, Arshad SH, Nadif R, Thijs C, Andersson N, Asarnoj A, Ballardini N, Ballereau S, Bedbrook A, Benet M, Bergstrom A, Brunekreef B, Burte E, Calderon M, De Carlo G, Demoly P, Eller E, Fantini MP, Hammad H, Hohman C, Just J, Kerkhof M, Kogevinas M, Kull I, Lau S, Lemonnier N, Mommers M, Nawijn M, Neubauer A, Oddie S, Pellet J, Pin I, Porta D, Saes Y, Skrindo I, Tischer CG, Torrent M, von Hertzen L.

    Are allergic multimorbidities and IgE polysensitization associated with the persistence or re-occurrence of foetal type 2 signalling? The MeDALL hypothesis. Allergy 2015; 70: 1062-1078.

    10. Bousquet J, Bachert C, Bernstein J, Canonica GW, Carr W, Dahl R, Demoly P, Devillier P, Hellings P, Fokkens W, Klimek L, Lieberman P, Meltzer E, Price D, Ryan D, Wahn U. Advances in pharmacotherapy for the treatment of allergic rhinitis; MP29-02 (a novel formulation of azelastine hydrochloride and fluticasone propionate in an advanced delivery system) fills the gaps. Expert Opinion on Pharmacotherapy 2015; 16: 913-928.

    11.

    Bousquet J, Kuh D, Bewick M, Standberg T, Farrell J, Pengelly R, Joel ME, Rodriguez Manas L, Mercier J, Bringer J, Camuzat T, Bourret R, Bedbrook A, Kowalski ML, Samolinski B, Bonini S, Brayne C, Michel JP, Venne J, Viriot-Durandal P, Alonso J, Avignon A, Ben-Shlomo Y, Bousquet PJ, Combe B, Cooper R, Hardy R, Iaccarino G, Keil T, Kesse-Guyot E, Momas I, Ritchie K, Robine JM, Thijs C, Tischer C, Vellas B, Zaidi A, Alonso F, Ranberg KA, Andreeva V, Ankri J, Arnavielhe S, Arshad H, Auge P, Berr C, Bertone P, Blain H, Blasimme A, Buijs GJ, Caimmi D, Carriazo A, Cesario A, Coletta J, Cosco T, Criton M, Cuisinier F, Demoly P, Fernandez-Nocelo S, Fougere B, Garcia-Aymerich J, Goldberg M, Guldemond N, Gutter Z, Harman D, Hendry A, Heve D, Illario M, Jeandel C, Krauss-Etschmann S, Krys O, Kula D, Laune D, Lehmann S, Maier D, Malva J, Matignon P, Melen E, Mercier G, Moda G, Nizinkska A, Nogues M, O’Neill M, Pelissier JY, Poethig D, Porta D, Postma D, Puisieux F, Richards M, Robalo-Cordeiro C, Romano V, Roubille F, Schulz H, Scott A, Senesse P, Slagter S, Smit HA, Somekh D, Stafford M, Suanzes J, Todo-Bom A, Touchon J, Traver-Salcedo V, Van Beurden M, Varraso R, Vergara I, Villalba-Mora E, Wilson N, Wouters E, Zins M.

    Operational definition of Athletic and Healthy Ageing (AHA): A conceptual framework. Journal of Nutrition Health & Aging 2015; 19: 955-960.

    12. Bousquet J, Kuh D, Bewick M, Strandberg T, Farrell J, Pengelly R, Joel ME, Manas LR, Mercier J, Bringer J, Camuzat T, Bourret R, Bedbrook A, Kowalski ML, Samolinski B, Bonini S, Brayne C, Michel JP, Venne J, Viriot-Durandal P, Alonso J, Avignon A, Bousquet PJ, Combe B, Cooper R, Hardy R, Iaccarino G, Keil T, Kesse-Guyot E, Momas I, Ritchie K, Robine JM, Thijs C, Tischer C, Vellas B, Zaidi A, Alonso F, Ranberg KA, Andreeva V, Ankri J, Arnavielhe S, Arshad SH, Auge P, Berr C, Bertone P, Blain H, Blasimme A, Buijs GJ, Caimmi D, Carriazo A, Cesario A, Coletta J, Cosco T, Criton M, Cuisinier F, Demoly P, Fernandez-Nocelo S, Fougere B, Garcia-Aymerich J, Goldberg M, Guldemond N, Gutter Z, Harman D, Hendry A, Heve D, Illario M, Jeandel C, Krauss-Etschmann S, Krys O, Kula D, Laune D, Lehmann S, Maier D, Malva J, Matignon P, Melen E, Mercier G, Moda G, Nizinkska A, Nogues M, O’Neill M, Pelissier JY, Poethig D, Porta D, Postma D, Puisieux F, Richards M, Robalo-Cordeiro C, Romano V, Roubille F, Schulz H, Scott A, Senesse P, Slagter S, Smit HA, Somekh D, Stafford M, Suanzes J, Todo-Bom A, Touchon J, Traver-Salcedo V, Van Beurden M, Varraso R, Vergara I, Villalba-Mora E, Wilson N, Wouters E, Zins M.

    Operative definition of athletic and healthy ageing (AHA): Meeting report. Montpellier October 20-21, 2014. European Geriatric Medicine 2015; 6: 196-200.

    13. Bousquet J, Malva J, Nogues M, Manas LR, Vellas B, Farrell J, Grp MR. Operational Definition of Athletic and Healthy Aging (AHA): The European Innovation Partnership (EIP) on AHA Reference Site Questionnaire: Montpellier October 20-21, 2014, Lisbon July 2, 2015. Journal of the American Medical Directors Association 2015; 16: 1020-1026.

    14.

    Bousquet J, Schunemann HJ, Fonseca J, Samolinski B, Bachert C, Canonica GW, Casale T, Cruz AA, Demoly P, Hellings P, Valiulis A, Wickman M, Zuberbier T, Bosnic-Anticevitch S, Bedbrook A, Bergmann KC, Caimmi D, Dahl R, Fokkens WJ, Grisle I, Lodrup Carlsen K, Mullol J, Muraro A, Palkonen S, Papadopoulos N, Passalacqua G, Ryan D, Valovirta E, Yorgancioglu A, Aberer W, Agache I, Adachi M, Akdis CA, Akdis M, Annesi-Maesano I, Ansotegui IJ, Anto JM, Arnavielhe S, Arshad H, Baiardini I, Baigenzhin AK, Barbara C, Bateman ED, Beghe B, Bel EH, Ben Kheder A, Bennoor KS, Benson M, Bewick M, Bieber T, Bindslev-Jensen C, Bjermer L, Blain H, Boner AL, Boulet LP, Bonini M, Bonini S, Bosse I, Bourret R, Bousquet PJ, Braido F, Briggs AH, Brightling CE, Brozek J, Buhl R, Burney PG, Bush A, Caballero-Fonseca F, Calderon MA, Camargos PAM, Camuzat T, Carlsen KH, Carr W, Sarabia AMC, Chavannes NH, Chatzi L, Chen YZ, Chiron R, Chkhartishvili E, Chuchalin AG, Ciprandi G, Cirule I, Correia de Sousa J, Cox L, Crooks G, Costa DJ, Custovic A, Dahlen SE, Darsow U, De Carlo G, De Blay F, Dedeu T, Deleanu D, Denburg JA, Devillier P, Didier A, Dinh-Xuan AT, Dokic D, Douagui H, Dray G, Dubakiene R, Durham SR, Dykewicz MS, El-Gamal Y, Emuzyte R, Wagner AF, Fletcher M, Fiocchi A, Forastiere F, Gamkrelidze A, Gemicioglu B, Gereda JE, Gonzalez Diaz S, Gotua M, Grouse L, Guzman MA, Haahtela T, Hellquist-Dahl B, Heinrich J, Horak F, Hourihane Occupation, Howarth P, Humbert M, Hyland ME, Ivancevich JC, Jares EJ, Johnston SL, Joos G, Jonquet O, Jung KS, Just J, Kaidashev I, Kalayci O, Kalyoncu AF, Keil T, Keith PK, Khaltaev N, Klimek L, N’Goran BK, Kolek V, Koppelman GH, Kowalski ML, Kull I, Kuna P, Kvedariene V, Lambrecht B, Lau S, Larenas-Linnemann D, Laune D, Le LTT, Lieberman P, Lipworth B, Li J, Louis R, Magard Y, Magnan A, Mahboub B, Majer I, Makela MJ, Manning P, De Manuel Keenoy E, Marshall GD, Masjedi MR, Maurer M, Mavale-Manuel S, Melen E, Melo-Gomes E, Meltzer EO, Merk H, Miculinic N, Mihaltan F, Milenkovic B, Mohammad Y, Molimard M, Momas I, Montilla-Santana A, Morais-Almeida M, Moesges R, Namazova-Baranova L, Naclerio R, Neou A, Neffen H, Nekam K, Niggemann B, Nyembue TD, O’Hehir RE, Ohta K, Okamoto Y, Okubo K, Ouedraogo S, Paggiaro P, Pali-Schoell I, Palmer S, Panzner P, Papi A, Park HS, Pavord I, Pawankar R, Pfaar O, Picard R, Pigearias B, Pin I, Plavec D, Pohl W, Popov TA, Portejoie F, Postma D, Potter P, Price D, Rabe KF, Raciborski F, Pontal FR, Repka-Ramirez S, Robalo-Cordeiro C, Rolland C, Rosado-Pinto J, Reitamo S, Rodenas F, Roman Rodriguez M, Romano A, Rosario N, Rosenwasser L, Rottem M, Sanchez-Borges M, Scadding GK, Serrano E, Schmid-Grendelmeier P, Sheikh A, Simons FER, Sisul JC, Skrindo I, Smit HA, Sole D, Sooronbaev T, Spranger O, Stelmach R, Strandberg T, Sunyer J, Thijs C, Todo-Bom A, Triggiani M, Valenta R, Valero AL, van Hage M, Vandenplas O, Vezzani G, Vichyanond P, Viegi G, Wagenmann M, Walker S, Wang DY, Wahn U, Williams DM, Wright J, Yawn BP, Yiallouros PK, Yusuf OM, Zar HJ, Zernotti ME, Zhang L, Zhong N, Zidarn M, Mercier J.

    MACVIA-ARIA Sentinel NetworK for allergic rhinitis (MASK-rhinitis): the new generation guideline implementation. Allergy 2015; 70: 1372-1392.

    15. Bousquet PJ, Devillier P, Tadmouri A, Mesbah K, Demoly P, Bousquet J. Clinical Relevance of Cluster Analysis in Phenotyping Allergic Rhinitis in a Real-Life Study. International Archives of Allergy and Immunology 2015; 166: 231-240.

    16. Boutin B, Koskas M, Guillo H, Maingot L, La Rocca M-C, Boule M, Just J, Momas I, Corinne A, Beydon N.

    Forced expiratory flows’ contribution to lung function interpretation in schoolchildren. European Respiratory Journal 2015; 45: 107-115.

    17. Bouzigon E, Nadif R, Le Moual N, Dizier MH, Aschard H, Boudier A, Bousquet J, Chanoine S, Donnay C, Dumas O, Gormand F, Jacquemin B, Just J, Margaritte-Jeannin P, Matran R, Pison C, Rage E, Rava M, Sarnowski C, Smit LAM, Temam S, Varraso R, Vignoud L, Lathrop M, Pin I, Demenais F, Kauffmann F, Siroux V. Genetic and environmental factors of asthma and allergy: Results of the EGEA study. Revue Des Maladies Respiratoires 2015; 32: 822-840.

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    Brunekreef B, Kuenzli N, Pekkanen J, Annesi-Maesano I, Forsberg B, Sigsgaard T, Keuken M, Forastiere F, Barry M, Querol X, Harrison RM. Clean air in Europe: beyond the horizon? (vol 45, pg 7, 2015). European Respiratory Journal 2015; 45: 861-861.

    19. Brunekreef B, Kuenzli N, Pekkanen J, Annesi-Maesano I, Forsberg B, Sigsgaard T, Keuken M, Forastiere F, Barry M, Querol X, Harrison RM. Clean air in Europe: beyond the horizon? European Respiratory Journal 2015; 45: 7-10.

    20. Burte E, Bousquet J, Varraso R, Gormand F, Just J, Matran R, Pin I, Siroux V, Jacquemin B, Nadif R.

    Characterization of Rhinitis According to the Asthma Status in Adults Using an Unsupervised Approach in the EGEA Study. Plos One 2015; 10.

    21. Buters J, Prank M, Sofiev M, Pusch G, Albertini R, Annesi-Maesano I, Antunes C, Behrendt H, Berger U, Brandao R, Celenk S, Galan C, Grewling L, Jackowiak B, Kennedy R, Rantio-Lehtimaki A, Reese G, Sauliene I, Smith M, Thibaudon M, Weber B, Cecchi L, Grp HW. Variation of the group 5 grass pollen allergen content of airborne pollen in relation to geographic location and time in season. Journal of Allergy and Clinical Immunology 2015; 136: 87-U179.

    22. Calderon MA, Cox L, Casale TB, Moesges R, Pfaar O, Malling H-J, Sastre J, Khaitov M, Demoly P.

    The effect of a new communication template on anticipated willingness to initiate or resume allergen immunotherapy: an internet-based patient survey. Allergy Asthma and Clinical Immunology 2015; 11.

    23. Calderon MA, Farina H, Duniau S, Demoly PM. Physician-Patient Communication Concerning Allergen Immunotherapy: Impact on Treatment Acceptance and Compliance. Journal of Allergy and Clinical Immunology 2015; 135: AB51-AB51.

    24. Calderon MA, Kleine-Tebbe J, Linneberg A, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, Demoly P. Home Dust Mite Respiratory Allergy: An Overview of Current Therapeutic Strategies.

    The journal of allergy and clinical immunology In practice 2015; 3: 843-855.

    25. Calderon MA, Linneberg A, Kleine-Tebbe J, De Blay F, Hernandez Fernandez de Rojas D, Virchow JC, Demoly P. Respiratory allergy caused by home dust mites: What do we really know? Journal of Allergy and Clinical Immunology 2015; 136: 38-48.

    26. Callec R, Lamy C, Perdriolle-Galet E, Patte C, Heude B, Morel O, Grp EM-CCS. Impact on obstetric outcome of third-trimester screening for small-for-gestational-age fetuses.

    Ultrasound in Obstetrics & Gynecology 2015; 46: 216-220.

    27. Carreiro-Martins P, Rosado-Pinto J, do Ceu Teixeira M, Neuparth N, Silva O, Papoila AL, Khaltaev N, Bousquet J, Annesi-Maesano I. Distribution and etiology of chronic respiratory diseases in primary healthcare departments in Cape Verde. Revue D Epidemiologie Et De Sante Publique 2015; 63: 305-313.

    28. Chanoine S, Dumas O, Benmerad M, Pison C, Varraso R, Gormand F, Just J, Le Moual N, Bedouch P, Bousquet J, Kauffmann F, Pin I, Siroux V. Long-term benefits of inhaled corticosteroids in asthma: the propensity score method.

    Pharmacoepidemiology and Drug Safety 2015; 24: 246-255.

    29. Chastang J, Baiz N, Cadwalladder JS, Robert S, Dywer J, Charpin DA, Caillaud D, de Blay F, Raherison C, Lavaud F, Annesi-Maesano I. Postnatal Environmental Tobacco Smoke Exposure Related to Behavioral Problems in Children. Plos One 2015; 10.

    30. Chastang J, Baiz N, Cadwallader JS, Robert S, Dywer JL, Charpin DA, Caillaud D, de Blay F, Raherison C, Lavaud F, Annesi-Maesano I. Postnatal Environmental Tobacco Smoke Exposure Related to Behavioral Problems in Children (vol 10, e0133604, 2015). Plos One 2015; 10.

    31.

    Dallongeville A, Le Cann P, Zmirou-Navier D, Chevrier C, Costet N, Annesi-Maesano I, Blanchard O. Concentration and determinants of molds and allergens in indoor air and home dust of French dwellings. Science of the Entire Environment 2015; 536: 964-972.

    32. D’Amato G, Holgate ST, Pawankar R, Ledford DK, Cecchi L, Al-Ahmad M, Al-Enezi F, Al-Muhsen S, Ansotegui I, Baena-Cagnani CE, Baker DJ, Bayram H, Bergmann KC, Boulet L-P, Buters JTM, D’Amato M, Dorsano S, Douwes J, Finlay SE, Garrasi D, Gomez M, Haahtela T, Halwani R, Hassani Y, Mahboub B, Marks G, Michelozzi P, Montagni M, Nunes C, Oh JJ-W, Popov TA, Portnoy J, Ridolo E, Rosario N, Rottem M, Sanchez-Borges M, Sibanda E, Sienra-Monge JJ, Vitale C, Annesi-Maesano I.

    Meteorological conditions, climate change, new emerging factors, and asthma and related allergic disorders. A statement of the World Allergy Organization. The World Allergy Organization journal 2015; 8: 25-25.

    33. D’Amato G, Vitale C, De Martino A, Viegi G, Lanza M, Molino A, Sanduzzi A, Vatrella A, Annesi-Maesano I, D’Amato M. Effects on asthma and respiratory allergy of Climate change and air pollution. Multidisciplinary respiratory medicine 2015; 10: 39-39.

    34. Demoly P, Aubier M, de Blay F, Wessel F, Clerson P, Maigret P.

    Evaluation of patients’ expectations and benefits in the treatment of allergic rhinitis with a new tool: the patient benefit index — the benefica study. Allergy Asthma and Clinical Immunology 2015; 11.

    35. Demoly P, Calderon MA, Casale TB, Malling H-J, Wahn U. «The worth of pre- and co-seasonal sublingual immunotherapy in pollen-induced allergic rhinoconjunctivitis». Clinical and translational allergy 2015; 5: 18-18.

    36. Demoly P, Lawton S, Villesen H, Virchow JC. Immunotherapy with sq-hdm slit-tablet is effective in the treatment of allergic rhinitis and allergic asthma.

    Internal Medicine Journal 2015; 45: 16-17.

    37. Demoly P, Milgrom H. By the numbers: bringing new drugs for allergic/hypersensitivity diseases to the market. Current Opinion in Allergy and Clinical Immunology 2015; 15: 195-196.

    38. Demoly P, Passalacqua G, Calderon MA, Yalaoui T. Choosing the optimal dose in sublingual immunotherapy: Rationale for the 300 index of reactivity dose. Clinical and translational allergy 2015; 5: 44-44.

    39. Demoly P, Serrano E, Didier A, Bousquet PJ, Mesbah K. Listening to and understanding French patients with allergic rhinitis: Observatory OPERA.

    Revue Francaise D Allergologie 2015; 55: 347-355.

    40. Deschildre A, Marguet C, Langlois C, Pin I, Rittie J-L, Derelle J, Abou Taam R, Fayon M, Brouard J, Dubus JC, Siret D, Weiss L, Pouessel G, Beghin L, Just J. Real-life long-term omalizumab therapy in children with severe allergic asthma. European Respiratory Journal 2015; 46: 856-859.

    41. Dinh-Xuan AT, Annesi-Maesano I, Berger P, Chambellan A, Chanez P, Chinet T, Degano B, Delclaux C, Demange V, Didier A, Garcia G, Magnan A, Mahut B, Roche N. Contribution of exhaled nitric oxide measurement in airway inflammation assessment in asthma.

    A position paper from the French Speaking Respiratory Society. Revue Des Maladies Respiratoires 2015; 32: 193-215.

    42. Doan S, Amat F, Gabison EE, Cochereau I, Just J. Experience with the monoclonal anti IgE antibody Omalizumab in severe refractory vernal keratoconjunctivitis in children. Investigative Ophthalmology & Visual Science 2015; 56.

    43. Fontaine C, Amat F, Paluel-Marmont C, Couderc R, Louha M, Annesi-Maesano I, Bernard A, Just J. Could serum pneumoproteins be new biomarkers for asthma phenotypes in infants? Revue Francaise D Allergologie 2015; 55: 312-316.

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    Foucher F, Hibrand-Saint Oyant L, Hamama L, Sakr S, Nybom H, Baudino S, Caissard JP, Hokanson SC, Byrne DM, Smulder JMS, Desnoye B, Debener T, Bruneau A, De Riek J, Matsumoto S, Torres A, Millan T, Amaya I, Yamada K, Wincker P, Zamir D, Gouzy J, Sargent D, Bendahmane M, Raymond O, Vergne P, Dubois A, Just J. Towards the Rose Genome Sequence and Its Use in Research and Breeding. In: Debener T, Linde M, editors. Vi International Symposium on Rose Research and Cultivation; 2015. p. 167-175.

    45. Garcia-Aymerich J, Benet M, Saeys Y, Pinart M, Basagana X, Smit HA, Siroux V, Just J, Momas I, Ranciere F, Keil T, Hohmann C, Lau S, Wahn U, Heinrich J, Tischer CG, Fantini MP, Lenzi J, Porta D, Koppelman GH, Postma DS, Berdel D, Koletzko S, Kerkhof M, Gehring U, Wickman M, Melen E, Hallberg J, Bindslev-Jensen C, Eller E, Kull I, Carlsen KCL, Carlsen KH, Lambrecht BN, Kogevinas M, Sunyer J, Kauffmann F, Bousquet J, Anto JM.

    Phenotyping asthma, rhinitis and eczema in MeDALL population-based birth cohorts: an allergic comorbidity cluster. Allergy 2015; 70: 973-984.

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    48. Hellings PW, Muraro A, Fokkens W, Mullol J, Bachert C, Canonica GW, Price D, Papadopoulos N, Scadding G, Rasp G, Demoly P, Murray R, Bousquet J.

    A common language to assess allergic rhinitis control: results from a survey conducted during EAACI 2013 Congress. Clinical and translational allergy 2015; 5: 36-36.

    49. Ibanez G, Bernard JY, Rondet C, Peyre H, Forhan A, Kaminski M, Saurel-Cubizolles M-J, Grp EM-CCS. Effects of Antenatal Maternal Depression and Anxiety on Children’s Early Cognitive Development: A Prospective Cohort Study. Plos One 2015; 10.

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    Allergic phenotypes in children. Revue Francaise D Allergologie 2015; 55: 108-109.

    51. Just J, Amat F, Deschildre A. Food allergy phenotypes: experiences of the cohorts. Revue Francaise D Allergologie 2015; 55: 474-479.

    52. Just J, Saint Pierre P, Amat F, Gouvis-Echraghi R, Lambert-Guillemot N, Guiddir T, Maesano IA. What lessons can be learned about asthma phenotypes in children from cohort studies? Pediatric Allergy and Immunology 2015; 26: 300-305.

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    Jutel M, Agache I, Bonini S, Burks AW, Calderon M, Canonica W, Cox L, Demoly P, Frew AJ, O’Hehir R, Kleine-Tebbe J, Muraro A, Lack G, Larenas D, Levin M, Nelson H, Pawankar R, Pfaar O, van Ree R, Sampson H, Santos AF, Du Toit G, Werfel T, van Wijk RG, Zhang L, Akdis CA. International consensus on allergy immunotherapy. Journal of Allergy and Clinical Immunology 2015; 136: 556-568.

    54. Kleine-Tebbe JR, Moen K, Rehm D, Demoly PM. The HDM Slit-Tablet Reduces Symptoms of Home Dust Mite Allergic Rhinitis Independently of Asthma Status and Allergen Sensitisation Type; A Subgroup Analysis of Results from a Dbpc Phase III Trial (MERIT).

    Journal of Allergy and Clinical Immunology 2015; 135: AB268-AB268.

    55. Klimek L, Hoffmann HJ, Renz H, Demoly P, Werfel T, Matricardi PM, Muraro A, Schmid-Grendelmeier P, Cardona V, Papadopoulos NG. Diagnostic test allergens used for in vivo diagnosis of allergic diseases are at risk: a European Perspective. Allergy 2015; 70: 1329-1331.

    56. Maio S, Sarno G, Baldacci S, Annesi-Maesano I, Viegi G. Air quality of nursing homes and its effect on the lung health of elderly residents. Expert Review of Respiratory Medicine 2015; 9: 671-673.

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    Melchior M, Hersi R, van der Waerden J, Larroque B, Saurel-Cubizolles MJ, Chollet A, Galera C, Grp EM-CCS. Maternal tobacco smoking in pregnancy and children’s socio-emotional development at age 5: The EDEN mother-child birth cohort study. European Psychiatry 2015; 30: 562-568.

    58. Moneret-Vautrin AD, Deschildre A, Just J, Bruyere O, van Der Brempt X, Beaudouin E, Elegbede F, Crepet A. Mirabel Project: Description of a French Population of 785 Peanut Allergic or Sensitized Patients.

    Journal of Allergy and Clinical Immunology 2015; 135: AB34-AB34.

    59. Nakhle MM, Farah W, Ziade N, Abboud M, Coussa-Koniski M-L, Annesi-Maesano I. Beirut Air Pollution and Health Effects — BAPHE study protocol and objectives. Multidisciplinary respiratory medicine 2015; 10: 21-21.

    60. Nakhle MM, Farah W, Ziade N, Abboud M, Salameh D, Annesi-Maesano I. Short-term relationships between emergency hospital admissions for respiratory and cardiovascular diseases and fine particulate air pollution in Beirut, Lebanon. Environmental Monitoring and Assessment 2015; 187.

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    Papadopoulos NG, Bernstein JA, Demoly P, Dykewicz M, Fokkens W, Hellings PW, Peters AT, Rondon C, Togias A, Cox LS. Phenotypes and endotypes of rhinitis and their impact on management: a PRACTALL report. Allergy 2015; 70: 474-494.

    62. Pitsios C, Demoly P, Bilo MB, van Wijk RG, Pfaar O, Sturm GJ, Rodriguez del Rio P, Tsoumani M, Gawlik R, Paraskevopoulos G, Rueff F, Valovirta E, Papadopoulos NG, Calderon MA. Clinical contraindications to allergen immunotherapy: an EAACI position paper. Allergy 2015; 70: 897-909.

    63. Price D, Smith P, Hellings P, Papadopoulos N, Fokkens W, Muraro A, Murray R, Chisholm A, Demoly P, Scadding G, Mullol J, Lieberman P, Bachert C, Mosges R, Ryan D, Bousquet J.

    Current controversies and challenges in allergic rhinitis management. Expert review of clinical immunology 2015; 11: 1205-1217.

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    Allergies are caused by foreign substances constantly bombarding your body—such as dander, pollen, dust, mold, chemicals, and certain foods. In response, your body has developed an immune system that produces antibodies to protect you.

    What is an allergy and how is allergy to pollen classified

    But sometimes immune systems overreact, producing in excess a certain antibody known as IgE, which causes allergic reactions.

    For those Americans who experience allergies every year—an estimated 1 in 5 people—there is always the hope that they can discover sustainable relief from the sneezing, coughing, runny noses, and watery, itchy eyes, and numerous other symptoms allergies can cause.

    We’re here to let you know that we can provide you the most up-to-date and effective techniques for managing your allergies, helping you understand more about the allergies that you or a loved one might be experiencing.

    Our allergy specialists work with patients of every age populations, so if your allergy concerns are for yourself, a young kid, or a more senior member of the family, we’ll proudly provide you the same comprehensive approach to allergy care your friends and neighbors own come to expect from Ear Nose & Throat Medical and Surgical Group.

    Allergens from this family

    The major birch pollen allergen, Bet v 1, is a member of the PR-10 family.

    Closely-related, cross-reactive allergens were found in the pollen of other trees from the order Fagales such as hazel, alder, oak and chestnut. Numerous birch pollen-allergic patients show allergic reactions to various fruits and vegetables, which are caused by IgE cross-reactivity between Bet v 1 and homologous allergens from plant foods [10]. Most Bet v 1-related food allergens were found in members of certain plant families: Rosaceae (apple, pear, rock fruits), Apiaceae (celery, carrot), and Fabaceae (soybean, peanut).

    Only two Bet v 1-related allergens were identified exterior the PR-10 subfamily. Vig r 6 is a minor allergen from mung bean and member of the cytokinin-specific binding proteins subfamily, a little subfamily distantly related to the PR-10 group [11]. Act d 11 is a minor kiwifruit allergen belonging to the MLP/RRP subfamily [12].

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    What are my treatment options?

    There are a number of treatment options available that may offer some relief from allergy symptoms.

    These options include avoidance, prescription and over-the-counter medications, and allergy immunotherapy (allergy shots or sublingual drops).

    Subcutaneous Immunotherapy (SCIT)

    1. Treatment: Injections of allergen extract
    2. istered: In your physician’s office
    3. Frequency: Weekly, for a 30-minute appointment
    4. Payment: Covered by most insurance plans

    Sublingual Immunotherapy (SLIT)

    1. Treatment: Drops of allergen taken orally
    2. istered: In your home
    3. Frequency: Quarterly, to pick up the next vial of drops
    4. Payment: Not covered by insurance; out-of-pocket expense for patient

    If you feel that your allergy medication and avoidance measures do not assist as much as you would love, you should consult one of our ENT Allergist specialists regarding evaluation and individualized treatment options available to you.

    How Do I Manage My Allergies?

    Avoid the allergen(s) – While this may work in some situations, some substances such as pollen are hard to avoid
    Treat the symptoms – Medication can provide you a measure of relief from your allergy symptoms, but it does nothing to address the root of the problem
    Use immunotherapy – Alter the body’s reaction to the allergen(s).

    To desensitize your immune system’s reaction to the effect of the offending allergen is the only treatment method known to cure your allergy

    With immunotherapy:

    1. You may use fewer ill days at work.
    2. Living your life as you desire to becomes easier.
    3. Other diseases such as asthma and sinusitis may be better controlled.
    4. You may use fewer medications.

    Those who suffer from one allergy may be more vulnerable to others, as allergens can stack up and increase symptoms. Our immunotherapy program provides patients with a testing and treatment plan that can improve overall health and well-being.

    Links to Pfam

    Family-defining Pfam domains (at least one of these domains is present in each family member):

    Pfam domain Pfam clan
    PF00407 Pathogenesis-related protein Bet v I family CL0209 Bet V 1 love

    What are My Testing Options?

    The first step in treating an allergy is to discover out what is causing the reaction.

    Radioallergosorbent Testing (RAST) involves sending a sample of your blood to a lab to be tested for allergens.

    We don’t typically recommend this method as allergens may not show up in blood and can be missed.

    Modified Quantitative Testing (MQT) is a state-of-the-art method. It combines both intradermal testing and skin-prick testing. This allows the healthcare provider to precisely identify the degree of reactivity. This is our preferred testing method as recommended by the American Academy of Otolaryngic Allergy (AAOA).

    Who could benefit?

    Allergy shots or sublingual drops are used for people with respiratory allergies caused by pollens, animal dander, molds and dust mites.

    Speak with your physician about your allergies and the individualized treatment options available to you. If you ponder you may be a candidate for immunotherapy, enquire your doctor about it today.


    Learn More About Allergy Care


    You may study to live with your allergies- but you don’t own to! Contact us today to study more about your allergies and to discover out if immunotherapy is correct for you.


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