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Since this medicine is used when needed, you may not be on a dosing schedule. If you are on a schedule, use the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not use additional medicine to make up the missed dose.

When you own headache pain, there’s a excellent chance you desire relief from the pain—fast. Over-the-counter medications love Excedrin® can assist ease your distress.

While deciding which Excedrin® treatment is correct for you, it’s useful to understand the uses, warnings, and side effects of each medication as well as how to handle them should they occur.


Excedrin® Additional Strength can assist you temporarily relieve minor aches and pains due to headache, a freezing, arthritis, muscular aches, toothache, premenstrual and menstrual cramps.

The warnings and side effects of Excedrin® Additional Strength are:

Reye’s syndrome: Children and teenagers who own or are recovering from chicken pox or flu-like symptoms should not use this product.

When using this product, if changes in behavior with nausea and vomiting happen, consult a doctor because these symptoms could be an early sign of Reye’s syndrome, a rare but serious illness.

Allergy alert: Acetaminophen may cause severe skin reactions. Symptoms may include:

  1. skin reddening
  2. blisters
  3. rash

If a skin reaction occurs, stop use and seek medical assist correct away.

Allergy alert: Aspirin may cause a severe allergic reaction which may include:

  1. hives
  2. asthma (wheezing)
  3. facial swelling
  4. shock

Liver warning: This product contains acetaminophen.

Severe liver damage may happen if you take

  1. more than 8 caplets in 24 hours, which is the maximum daily amount
  2. with other drugs containing acetaminophen
  3. 3 or more alcoholic drinks every day while using this product

Stomach bleeding warning: This product contains an NSAID, which may cause severe stomach bleeding. The chance is higher if you

  1. have had stomach ulcers or bleeding problems
  2. take other drugs containing prescription or nonprescription NSAIDs (aspirin, ibuprofen, naproxen, or others)
  3. have 3 or more alcoholic drinks every day while using this product
  4. are age 60 or older
  5. take a blood thinning (anticoagulant) or steroid drug
  6. take more or for a longer time than directed

Caffeine warning: The recommended dose of this product contains about as much caffeine as a cup of coffee.

Limit the use of caffeine-containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and, occasionally, rapid heart beat.

Do not use:

  1. if you own ever had an allergic reaction to acetaminophen, aspirin or any other pain reliever/fever reducer
  2. with any other drug containing acetaminophen (prescription or nonprescription).

    If you are not certain whether a drug contains acetaminophen, enquire a doctor or pharmacist.

Ask a doctor before use if:

  1. stomach bleeding warning applies to you
  2. you own high blood pressure, heart disease, liver cirrhosis, or kidney disease
  3. you are taking a diuretic
  4. you own liver disease
  5. you own a history of stomach problems, such as heartburn
  6. you own asthma

Ask a doctor or pharmacist before use if you are taking:

  1. a prescription drug for diabetes, gout, or arthritis
  2. any other drug, or are under a doctor’s care for any serious condition

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What is the most significant information I should know about acetaminophen and diphenhydramine?

Do not take more of this medication than is recommended.

An overdose of acetaminophen can damage your liver or cause death.

In rare cases, acetaminophen may cause a severe skin reaction. Stop taking this medicine and call your doctor correct away if you own skin redness or a rash that spreads and causes blistering and peeling.

Ask a doctor or pharmacist before using any other freezing, allergy, pain, or sleep medication. Acetaminophen (sometimes abbreviated as APAP) is contained in numerous combination medicines. Taking certain products together can cause you to get too much acetaminophen which can lead to a fatal overdose. Check the label to see if a medicine contains acetaminophen or APAP.

Avoid drinking alcohol.

It may increase your risk of liver damage while taking acetaminophen.

How should I take acetaminophen and diphenhydramine?

Use this medication exactly as directed on the label, or as prescribed by your doctor. Do not take this medicine for longer than recommended. Freezing or allergy medicine is generally taken only for a short time until your symptoms clear up.

Do not take more of this medication than is recommended. An overdose of acetaminophen can damage your liver or cause death.

Stop taking the medicine and call your doctor if you still own a fever after 3 days, or you still own pain after 10 days (or 5 days if treating a child).

Also call your doctor if your symptoms get worse, or if you own any redness or swelling.

If you need surgery or medical tests, tell the doctor ahead of time if you own taken this medicine within the past few days.

Store at room temperature away from moisture and heat.

What is acetaminophen and diphenhydramine?

Acetaminophen is a pain reliever and a fever reducer.

Diphenhydramine is an antihistamine that reduces the natural chemical histamine in the body. Histamine can produce symptoms of sneezing, itching, watery eyes, and runny nose.

Acetaminophen and diphenhydramine is a combination medicine used to treat headache, runny nose, sneezing, watery eyes, and pain or fever caused by allergies, the common freezing, or the flu.

Acetaminophen and diphenhydramine may also be used for purposes not listed in this medication guide.

What should I discuss with my healthcare provider before taking acetaminophen and diphenhydramine?

Ask a doctor before taking medicine that contains acetaminophen if you own ever had liver disease, or if you drink more than 3 alcoholic beverages per day.

You should not use this medication if you are allergic to it, or if you have:

  1. severe constipation, blockage in your stomach or intestines;
  2. untreated or uncontrolled diseases—glaucoma, asthma, heart disease, overactive thyroid; or
  3. if you are unable to urinate.

Ask a doctor or pharmacist before taking this medicine if you own any medical condition, especially:

  1. kidney disease;
  2. an enlarged prostate, problems with urination;
  3. a history of alcoholism; or
  4. cough with mucus, or cough caused by emphysema or chronic bronchitis;
  5. if you take potassium (Cytra, Epiklor, K-Lyte, K-Phos, Kaon, Klor-Con, Polycitra, Urocit-K).

It is not known whether this medicine will harm an unborn baby.

Do not use freezing or allergy medicine without a doctor’s advice if you are pregnant.

This medicine can pass into breast milk and may harm a nursing baby. Antihistamines may slow breast milk production. Do not use freezing or allergy without a doctor’s advice if you are breast-feeding a baby.

Always enquire a doctor before giving a freezing or allergy medicine to a child. Death can happen from the misuse of cough and freezing medicines in extremely young children.

What happens if I overdose?

Seek emergency medical attention or call the Poison Assist line at 1-800-222-1222.

An overdose of acetaminophen can be fatal.

The first signs of an acetaminophen overdose include loss of appetite, nausea, vomiting, stomach pain, sweating, and confusion or weakness. Later symptoms may include pain in your upper stomach, dark urine, and yellowing of your skin or the whites of your eyes.