What does a skin allergy test look like

A microscopic quantity of an allergen is introduced to a patient’s skin by various means:[1]

  1. Skin prick test: pricking the skin with a needle or pin containing a little quantity of the allergen.[2]
  2. Skin scratch test: a deep dermic scratch is performed with assist of the blunt bottom of a lancet.[3]
  3. Intradermic test: a tiny quantity of allergen is injected under the dermis with a hypodermic syringe.
  4. Skin scrape Test: a superficial scrape is performed with assist of the bovel of a needle to remove the superficial layer of the epidermis.[4]
  5. Patch test: applying a patch to the skin, where the patch contains the allergen

If an immuno-response is seen in the form of a rash, urticaria (hives), or (worse)anaphylaxis it can be concluded that the patient has a hypersensitivity (or allergy) to that allergen.

Further testing can be done to identify the specific allergen.

The «skin scratch test» as it is called, is not extremely commonly used due to increased likelihood of infection. On the other hand, the «skin scrape test» is painless, does not leave residual pigmentation and does not own a risk of infection, since it is limited to the superficial layer of the skin.

Some allergies are identified in a few minutes but others may take several days.

In every cases where the test is positive, the skin will become raised, red and appear itchy. The results are recorded — larger wheals indicating that the subject is more sensitive to that specific allergen. A negative test does not conclusively law out an allergy; occasionally, the concentration needs to be adjusted, or the body fails to elicit a response.

Immediate reactions tests

In the prick, scratch and scrape tests, a few drops of the purified allergen are gently pricked on to the skin surface, generally the forearm.

This test is generally done in order to identify allergies to pet dander, dust, pollen, foods or dust mites. Intradermal injections are done by injecting a little quantity of allergen just beneath the skin surface. The test is done to assess allergies to drugs love penicillin[5] or bee venom.

What does a skin allergy test glance like

To ensure that the skin is reacting in the way it is supposed to, every skin allergy tests are also performed with proven allergens love histamine, and non-allergens love glycerin. The majority of people do react to histamine and do not react to glycerin. If the skin does not react appropriately to these allergens then it most likely will not react to the other allergens. These results are interpreted as falsely negative.[6]

Delayed reactions tests

See also: Patch test

The patch test simply uses a large patch which has diverse allergens on it.

What does a skin allergy test glance like

The patch is applied onto the skin, generally on the back. The allergens on the patch include latex, medications, preservatives, hair dyes, fragrances, resins and various metals.

Skin finish point titration

Also called an intradermal test, this skin finish point titration (SET) uses intradermal injection of allergens at increasing concentrations to measure allergic response.[7] To prevent a severe allergic reaction, the test is started with a extremely dilute solution.

After 10 minutes, the injection site is measured to glance for growth of wheal, a little swelling of the skin. Two millimeters of growth in 10 minutes is considered positive. If 2 mm of growth is noted, then a second injection at a higher concentration is given to confirm the response. The finish point is the concentration of antigen that causes an increase in the size of the wheal followed by confirmatory whealing. If the wheal grows larger than 13 mm, then no further injection are given since this is considered a major reaction.


There are no major preparations required for skin testing. At the first consult, the subject’s medical history is obtained and physical examination is performed. Every consumers should bring a list of their medications because some may interfere with the testing. Other medications may increase the chance of a severe allergic reaction. Medications that commonly interfere with skin testing include the following:

Consumers who undergo skin testing should know that anaphylaxis can happen anytime. So if any of the following symptoms are experienced, a physician consultation is recommended immediately:

  1. Low grade Fever
  2. Lightheadedness or dizziness
  3. Wheezing or Shortness of breath
  4. Extensive skin rash
  5. Swelling of face, lips or mouth
  6. Difficulty swallowing or speaking


Even though skin testing may seem to be a benign procedure, it does own some risks, including swollen red bumps (hives) which may happen after the test.

The hives generally vanish in a few hours after the test.

What does a skin allergy test glance like

In rare cases they can persist for a day or two. These hives may be itchy and are best treated by applying an over the counter hydrocortisone cream.[8] In extremely rare cases one may develop a full blown allergic reaction. Physicians who act out skin test always own equipment and medications available in case an anaphylaxis reaction occurs. This is the main reason why consumers should not get skin testing performed at corner stores or by people who own no medical training.

Antihistamines, which are commonly used to treat allergy symptoms, interfere with skin tests, as they can prevent the skin from reacting to the allergens being tested.

People who take an antihistamine need either to select a diverse form of allergy test or to stop taking the antihistimine temporarily before the test. The period of time needed can range from a day or two to 10 days or longer, depending on the specific medication. Some medications not primarily used as antihistamines, including tricyclic antidepressants, phenothiazine-based antipsychotics, and several kinds of medications used for gastrointestinal disorders, can similarly interfere with skin tests.[9]

People who own severe, generalized skin disease or an acute skin infection should not undergo skin testing, as one needs uninvolved skin for testing.

Also, skin testing should be avoided for people at a heightened risk of anaphylactic shock, including people who are known to be highly sensitive to even the smallest quantity of allergen.[10]

Besides skin tests, there are blood tests which measure a specific antibody in the blood. The IgE antibody plays a vital role in allergies but its levels in blood do not always correlate with the allergic reaction.[11]

There are numerous alternative health care practitioners who act out a variety of provocation neutralization tests, but the vast majority of these tests own no validity and own never been proven to work scientifically.

What does a skin allergy test glance like

Skin prick testing

Skin prick testing is one of the most common allergy tests.

It involves putting a drop of liquid onto your forearm that contains a substance you may be allergic to. The skin under the drop is then gently pricked.

If you’re allergic to the substance, an itchy, red bump will appear within 15 minutes.

Most people discover skin prick testing not particularly painful, but it can be a little uncomfortable. It’s also extremely safe.

Make certain you do not take antihistamines before the test, as they can interfere with the results.

Blood tests

Blood tests may be used instead of, or alongside, skin prick tests to assist diagnose common allergies.

A sample of your blood is removed and analysed for specific antibodies produced by your immune system in response to an allergen.

External links

A person receiving a skin allergy test

  • ^Marwood, Joseph; Aguirrebarrena, Gonzalo; Kerr, Stephen; Welch, Susan A; Rimmer, Janet (2017-10-01).

    «De-labelling self-reported penicillin allergy within the emergency department through the use of skin tests and oral drug provocation testing». Emergency Medicine Australasia. 29 (5): 509–515. doi:10.1111/1742-6723.12774. ISSN 1742-6723.

    What does a skin allergy test glance like

    PMID 28378949.

  • ^Allergy Testing — August 15,2002 — American Family Physician, Retrieved on 2010-01-20.
  • ^Olivier CE, Argentão DGP, Santos RAPG, Silva MD, Lima RPS, Zollner RL. Skin scrape test: an inexpensive and painless skin test for recognition of immediate hypersensitivity in children and adults. The Open Allergy Journal 2013; 6:9-17. LinkArchived August 3, 2013, at the Wayback Machine
  • ^Skin test for Allergy, Retrieved on 2010-01-20.
  • ^American Academy of Allergy Asthma & Immunology: What is Allergy Testing?, Retrieved on 2010-01-20.

    |archive-url=https://web.archive.org/web/20120120175201/https://www.aaaai.org/conditions-and-treatments/library/at-a-glance/allergy-testing.aspx |archive-date=20 January 2012

  • ^Indrajana T, Spieksma FT, Voorhorst R.

    What does a skin allergy test glance like

    Comparative study of the intracutaneous, scratch and prick tests in allergy. Ann Allergy 1971; 29:639-50.

  • ^Bernstein IL, Li JT, Bernstein DI, Hamilton R, Spector SL, Tan R, et al. Allergy diagnostic testing: an updated practice parameter. Ann Allergy Asthma Immunol 2008; 100:S1-148.
  • ^Skin Test End-Point Titration at the US National Library of Medicine Medical Subject Headings (MeSH)
  • ^Basomba A, Sastre A, Pelaez A, Romar A, Campos A, Garcia-Villalmanzo A.

    Standardization of the prick test. A comparative study of three methods. Allergy 1985; 40:395-9.

  • ^Skin Testing and Allergy Injection Treatment for Allergies and Asthma — The University of Arizona Health Sciences Middle, Retrieved on 2010-01-20.
  • ^Skin Testing Basic Information, Retrieved on 2010-01-20. Archived January 14, 2010, at the Wayback Machine

If you ponder you own an allergy, tell your GP about the symptoms you’re having, when they happen, how often they happen and if anything seems to trigger them.

Your GP can offer advice and treatment for mild allergies with a clear cause.

If your allergy is more severe or it’s not obvious what you’re allergic to, you may be referred for allergy testing at a specialist allergy clinic.

Find your nearest NHS allergy clinic

The tests that may be carried out are described on this page.

If you ponder you own an allergy, tell your GP about the symptoms you’re having, when they happen, how often they happen and if anything seems to trigger them.

Your GP can offer advice and treatment for mild allergies with a clear cause.

If your allergy is more severe or it’s not obvious what you’re allergic to, you may be referred for allergy testing at a specialist allergy clinic.

Find your nearest NHS allergy clinic

The tests that may be carried out are described on this page.